Published in Mol Cell Endocrinol on May 16, 2013
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. Physiol Rep (2016) 1.40
Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol (2015) 0.88
Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases. Oxid Med Cell Longev (2015) 0.83
Effect of Dietary Patterns on Muscle Strength and Physical Performance in the Very Old: Findings from the Newcastle 85+ Study. PLoS One (2016) 0.79
Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome. Eur J Nutr (2015) 0.78
Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg. Age (Dordr) (2014) 0.78
Muscle Decline in Aging and Neuromuscular Disorders - Mechanisms and Countermeasures: Terme Euganee, Padova (Italy), April 13-16, 2016. Eur J Transl Myol (2016) 0.75
Age-related changes in skeletal muscle mitochondria: the role of exercise. Integr Med Res (2016) 0.75
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol (1998) 10.23
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2006) 7.38
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
The biologic clock: the mitochondria? J Am Geriatr Soc (1972) 6.36
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem (1967) 5.20
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol Respir Environ Exerc Physiol (1984) 4.55
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med (2008) 4.44
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11
Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A (2005) 4.03
Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc (2003) 4.02
Sarcopenia: origins and clinical relevance. J Nutr (1997) 3.88
Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr (2000) 3.68
Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr (2009) 3.44
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet (1989) 3.27
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes (2003) 3.23
Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc (2007) 2.94
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol (2002) 2.88
New records in aerobic power among octogenarian lifelong endurance athletes. J Appl Physiol (1985) (2012) 2.84
Endurance exercise as a countermeasure for aging. Diabetes (2008) 2.83
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol (1997) 2.69
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci U S A (1996) 2.52
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. J Biol Chem (2006) 2.51
Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012) 2.46
Oxidative capacity and ageing in human muscle. J Physiol (2000) 2.44
Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet (2006) 2.43
Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. N Engl J Med (2011) 2.36
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc (2011) 2.34
Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. J Clin Invest (2004) 2.24
Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol (2008) 2.20
Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem (2000) 2.13
Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J Appl Physiol (1985) (1992) 2.06
Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol (1985) (2007) 2.04
New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol (1985) (2007) 2.01
The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp Gerontol (2004) 1.98
Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am J Physiol Endocrinol Metab (2003) 1.96
Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J (2004) 1.95
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proc Natl Acad Sci U S A (2007) 1.86
Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes (2009) 1.82
Endurance training in humans: aerobic capacity and structure of skeletal muscle. J Appl Physiol (1985) (1985) 1.77
Mitochondrial structure and function are disrupted by standard isolation methods. PLoS One (2011) 1.74
Single muscle fibre contractile properties in young and old men and women. J Physiol (2003) 1.74
Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci (1992) 1.74
PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.71
Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve (1983) 1.70
A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci (2007) 1.65
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest (2007) 1.65
Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab (2012) 1.64
Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol (2004) 1.61
Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number. Biochim Biophys Acta (2012) 1.59
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One (2010) 1.58
Inverse associations between muscle mass, strength, and the metabolic syndrome. Metabolism (2009) 1.54
Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers. Aging Cell (2010) 1.52
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia (2008) 1.50
Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise. Am J Physiol Endocrinol Metab (2001) 1.50
Proteolytic gene expression differs at rest and after resistance exercise between young and old women. J Gerontol A Biol Sci Med Sci (2007) 1.49
Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab (2005) 1.49
Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta (1994) 1.48
Oxidative capacity of human muscle fiber types: effects of age and training status. J Appl Physiol (1985) (1995) 1.47
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem (2011) 1.46
Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A Biol Sci Med Sci (2012) 1.44
Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab (2012) 1.44
Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans. Pflugers Arch (2003) 1.44
Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans. Pflugers Arch (1985) 1.44
Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging. J Appl Physiol (1985) (1998) 1.42
Aerobic exercise training improves whole muscle and single myofiber size and function in older women. Am J Physiol Regul Integr Comp Physiol (2009) 1.39
Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci U S A (2010) 1.38
Aging and exercise training in skeletal muscle: responses of glutathione and antioxidant enzyme systems. Am J Physiol (1994) 1.36
Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training. J Appl Physiol (1985) (2005) 1.36
In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins. Am J Physiol Endocrinol Metab (2008) 1.36
Exercise-induced histone modifications in human skeletal muscle. J Physiol (2009) 1.36
Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria. Exp Gerontol (2003) 1.34
The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure. J Gerontol A Biol Sci Med Sci (2009) 1.33
Skeletal muscle oxidative capacity in young and older women and men. J Appl Physiol (1985) (2000) 1.33
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett (2002) 1.32
Methods for assessing mitochondrial function in diabetes. Diabetes (2013) 1.31
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell (2012) 1.29
Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood) (2003) 1.28
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes (2004) 1.24
Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J (2008) 1.24
Resistance training improves single muscle fiber contractile function in older women. Am J Physiol Cell Physiol (2001) 1.22
Fiber type- and position-dependent expression of a myosin light chain-CAT transgene detected with a novel histochemical stain for CAT. J Cell Biol (1991) 1.19
Muscle protein synthesis and gene expression during recovery from aerobic exercise in the fasted and fed states. Am J Physiol Regul Integr Comp Physiol (2010) 1.16
Skeletal muscle hypertrophy and muscle myostatin reduction after resistive training in stroke survivors. Stroke (2010) 1.15
Oxidative stress and severe walking disability among older women. Am J Med (2007) 1.15
Protein synthesis and the expression of growth-related genes are altered by running in human vastus lateralis and soleus muscles. Am J Physiol Regul Integr Comp Physiol (2008) 1.13
Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res (2000) 1.13
Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem J (1998) 1.12
Molecular adaptations to aerobic exercise training in skeletal muscle of older women. J Gerontol A Biol Sci Med Sci (2010) 1.11
Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults. J Gerontol A Biol Sci Med Sci (2012) 1.09
Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet. Am J Physiol Endocrinol Metab (2013) 1.04
Regulation of skeletal muscle mitochondrial function: genes to proteins. Acta Physiol (Oxf) (2010) 0.97