Published in Mol Cell Biol on May 28, 2013
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal (2014) 1.79
Mechanisms of Jak/STAT signaling in immunity and disease. J Immunol (2015) 1.27
STAT3 and epithelial-mesenchymal transitions in carcinomas. JAKSTAT (2014) 1.24
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity (2015) 1.17
The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene (2014) 1.05
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet (2016) 1.02
Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas. Genome Biol (2015) 0.90
Circadian disruption-induced microRNAome deregulation in rat mammary gland tissues. Oncoscience (2015) 0.89
Local and systemic factors and implantation: what is the evidence? Fertil Steril (2016) 0.84
STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells. J Immunol (2016) 0.82
Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. Carcinogenesis (2013) 0.82
BCL6--regulated by AhR/ARNT and wild-type MEF2B--drives expression of germinal center markers MYBL1 and LMO2. Haematologica (2015) 0.82
STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b. Cancers (Basel) (2014) 0.81
ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings. Sci Signal (2016) 0.80
Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog (2016) 0.77
Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolism. PLoS One (2014) 0.77
Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification. Oncotarget (2014) 0.76
Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Mol Cell Endocrinol (2014) 0.76
All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo. Blood (2016) 0.75
Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol (2017) 0.75
STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity. Biology (Basel) (2017) 0.75
Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. Biol Reprod (2016) 0.75
The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin Cancer Res (2016) 0.75
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis (2016) 0.75
Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells. Oncogene (2017) 0.75
The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus. Oman Med J (2017) 0.75
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance. Sci Rep (2017) 0.75
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell (2005) 14.32
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell (1995) 10.16
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell (2007) 3.81
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol (1997) 3.18
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63
Association between plasma prolactin concentrations and risk of breast cancer among predominately premenopausal women. Cancer Res (2006) 2.27
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res (2005) 1.82
STAT signaling in the pathogenesis and treatment of leukemias. Oncogene (2000) 1.81
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene (2006) 1.79
Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res (2009) 1.72
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood (2008) 1.53
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem (2004) 1.53
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem (2012) 1.51
CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol (2008) 1.41
Targeting signal transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol (2009) 1.40
Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol (2011) 1.36
The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol Endocrinol (2005) 1.33
BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation. Oncogene (2003) 1.30
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc Natl Acad Sci U S A (2002) 1.30
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Cancer Res (2010) 1.23
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha). Oncogene (2003) 1.20
Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol (2009) 1.12
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice. Int J Cancer (2004) 1.10
StAT signaling in cancer: insights into pathogenesis and treatment strategies. Cancer Treat Res (2003) 1.01
Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription. Oncogene (2007) 0.99
Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells. Leukemia (2011) 0.95
Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation. Biochem Biophys Res Commun (2004) 0.86
Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. Mol Endocrinol (2000) 0.82
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med (2005) 6.04
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood (2006) 4.46
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2009) 2.54
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature (2008) 2.47
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae. Nat Struct Mol Biol (2010) 2.40
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood (2011) 2.23
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet (2013) 2.21
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res (2006) 1.97
Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol (2010) 1.88
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol (2012) 1.88
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev (2013) 1.87
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res (2005) 1.82
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell (2013) 1.80
CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res (2009) 1.80
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal (2014) 1.79
Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res (2007) 1.78
Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology (2005) 1.78
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell (2010) 1.73
Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res (2009) 1.72
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell (2012) 1.63
STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 1.62
Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis. Proc Natl Acad Sci U S A (2010) 1.56
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood (2008) 1.53
Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem (2004) 1.53
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res (2006) 1.52
The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells. Blood (2003) 1.51
The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood (2005) 1.51
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci (2008) 1.36
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer Biol Ther (2011) 1.26
A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation. Oncotarget (2011) 1.26
The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem (2011) 1.22
Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. Proc Natl Acad Sci U S A (2004) 1.22
Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3. Mol Cell Biol (2003) 1.17
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol Pharmacol (2010) 1.12
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet (2011) 1.09
Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2. Mol Cancer Ther (2014) 1.09
Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. EMBO J (2011) 1.08
Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. Biochemistry (2006) 1.08
The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations. Genes Cancer (2012) 1.05
A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res (2007) 1.04
Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer. Mol Cell Endocrinol (2013) 1.04
Differential cofactor requirements for histone eviction from two nucleosomes at the yeast PHO84 promoter are determined by intrinsic nucleosome stability. Mol Cell Biol (2009) 1.03
Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. Cancer Biol Ther (2004) 1.03
Chromatin signature of widespread monoallelic expression. Elife (2013) 1.03
Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A (2014) 1.02
Targeting transcription factors: promising new strategies for cancer therapy. Curr Opin Oncol (2013) 1.00
STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1. Blood (2003) 1.00
Passing messages between biological networks to refine predicted interactions. PLoS One (2013) 0.99
Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets. JAKSTAT (2012) 0.98
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biol (2014) 0.97
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. J Biol Chem (2006) 0.95
Prediction of Polycomb target genes in mouse embryonic stem cells. Genomics (2010) 0.94
Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res (2011) 0.93
STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT (2012) 0.92
Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. J Natl Cancer Inst (2006) 0.90
Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model. BMC Bioinformatics (2010) 0.89
Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. J Immunol (2006) 0.89
Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J Invest Dermatol (2006) 0.88
Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem (2015) 0.87
A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells. Leuk Res (2005) 0.86
A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury. J Am Soc Nephrol (2013) 0.85
Sustained complete remission of CLL associated with the use of a Chinese herbal extract: case report and mechanistic analysis. Leuk Res (2003) 0.84
Discovery and characterization of novel mutant FLT3 kinase inhibitors. Mol Cancer Ther (2010) 0.84
STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents. Mol Cell Pharmacol (2011) 0.84
A multi-layer method to study genome-scale positions of nucleosomes. Genomics (2008) 0.83
A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis. Transl Oncogenomics (2007) 0.83
Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo. Leuk Res (2004) 0.83
Combination of two anti-CD5 monoclonal antibodies synergistically induces complement-dependent cytotoxicity of chronic lymphocytic leukaemia cells. Br J Haematol (2013) 0.82
In vivo activation of signal transducer and activator of transcription 1 after CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response. Clin Cancer Res (2003) 0.82
A tiered hidden Markov model characterizes multi-scale chromatin states. Genomics (2013) 0.81
Chromatin states accurately classify cell differentiation stages. PLoS One (2012) 0.80
IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Carcinogenesis (2004) 0.80
STAT1 expression is not required for polyp formation in Min mice. Mol Carcinog (2008) 0.79
A motif-independent metric for DNA sequence specificity. BMC Bioinformatics (2011) 0.78
Applications of alignment-free methods in epigenomics. Brief Bioinform (2013) 0.77
Modeling the dynamics of bivalent histone modifications. PLoS One (2013) 0.76
ACP Journal Club. Review: low-dose CT screening reduces lung cancer and mortality in current or former smokers. Ann Intern Med (2013) 0.75
A methodology to assess the intrinsic discriminative ability of a distance function and its interplay with clustering algorithms for microarray data analysis. BMC Bioinformatics (2013) 0.75
ACP Journal Club. Review: Self-collected samples are less accurate for HPV testing than clinician-collected samples. Ann Intern Med (2014) 0.75
MARRYING STEP FEED WITH CLARIFIER IMPROVEMENTS INCREASE WET WEATHER CAPACITY: INTEGRATED METHODOLOGY. Water Environ Res (2017) 0.75
Rare mutations provide unique insight into oncogenic potential of STAT transcription factors. J Clin Invest (2017) 0.75