Calcium signaling in the liver.

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metab (2015) 0.89

Chronic alcohol feeding potentiates hormone-induced calcium signalling in hepatocytes. J Physiol (2017) 0.87

Calcium signaling and the secretory activity of bile duct epithelia. Cell Calcium (2014) 0.84

INTRACELLULAR SIGNALING BY BILE ACIDS. J Biosci (Rajshari) (2012) 0.78

De novo characterization of the liver transcriptome of javelin goby Synechogobius hasta and analysis of its transcriptomic profile following waterborne copper exposure. Fish Physiol Biochem (2015) 0.77

Apical localization of inositol 1,4,5-trisphosphate receptors is independent of extended synaptotagmins in hepatocytes. PLoS One (2014) 0.76

Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun (2016) 0.75

Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42

The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol (2000) 19.46

Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97

Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16

Inositol phosphates and cell signalling. Nature (1989) 17.78

Liver fibrosis. J Clin Invest (2005) 17.27

Death receptors: signaling and modulation. Science (1998) 16.95

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

Global epidemiology of hepatitis C virus infection. Lancet Infect Dis (2005) 16.44

The Bcl-2 protein family: arbiters of cell survival. Science (1998) 16.08

Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87

BCL-2 family members and the mitochondria in apoptosis. Genes Dev (1999) 13.52

Liver regeneration. Science (1997) 12.80

Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature (1983) 10.90

Integrins and signal transduction pathways: the road taken. Science (1995) 10.71

Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature (1991) 10.32

Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature (1997) 9.99

Proliferation, cell cycle and apoptosis in cancer. Nature (2001) 9.57

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24

Calcium oscillations increase the efficiency and specificity of gene expression. Nature (1998) 9.19

Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98

Calcium signaling. Cell (1995) 8.87

The mitochondrial permeability transition pore and its role in cell death. Biochem J (1999) 7.72

Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet (2002) 7.67

Liver regeneration. Hepatology (2006) 7.52

Diversity of G proteins in signal transduction. Science (1991) 7.41

Decoding of cytosolic calcium oscillations in the mitochondria. Cell (1995) 7.31

Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science (1998) 7.29

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26

Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A (2003) 6.46

Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol (2004) 6.36

Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev (1999) 6.30

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science (1993) 6.29

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14

Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science (1991) 6.13

MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol (2010) 5.44

Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes. Nature (1986) 5.31

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28

Elementary and global aspects of calcium signalling. J Physiol (1997) 5.08

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature (1989) 5.02

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 5.01

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93

Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell (2011) 4.91

Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev (2006) 4.87

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration. Proc Natl Acad Sci U S A (1992) 4.41

NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology (2002) 4.34

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A (2004) 4.17

Calcium rises abruptly and briefly throughout the cell at the onset of anaphase. Science (1986) 4.05

The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene (2010) 4.00

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol (1999) 4.00

Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes. J Physiol (1995) 3.96

Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90

Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis (2007) 3.75

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell (1997) 3.71

Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration. Nature (1989) 3.65

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res (2006) 3.64

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem (2006) 3.57

Bcl-2 family proteins. Oncogene (1998) 3.56

Cytosolic calcium oscillators. FASEB J (1988) 3.37

Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol (1994) 3.34

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature (1995) 3.32

The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J (2006) 3.26

A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J Biol Chem (1995) 3.23

Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. J Biol Chem (1995) 3.20

The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol (2010) 3.19

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Cell (2002) 3.16

Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev (2004) 3.14

Mitochondrial calcium transport: physiological and pathological relevance. Am J Physiol (1994) 3.14

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13

Regulation of inositol phospholipid-specific phospholipase C isozymes. J Biol Chem (1992) 3.11

Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta (2009) 3.10

Cytosolic Ca2+ gradients triggering unidirectional fluid secretion from exocrine pancreas. Nature (1991) 3.10

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol (2009) 3.04

Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein. J Cell Biol (1986) 3.03

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J (1999) 3.03

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00

The enigmatic X gene of hepatitis B virus. J Virol (2004) 2.98

Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science (2001) 2.98

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol (2005) 2.94

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature (1997) 2.93

The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal (2006) 2.92

Spatial and temporal aspects of cellular calcium signaling. FASEB J (1996) 2.87

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol (1995) 2.87

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. Proc Natl Acad Sci U S A (2000) 2.87

Targeted therapies for hepatocellular carcinoma. Gastroenterology (2011) 2.85

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene (2007) 2.85

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol (1993) 2.84

Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J (1998) 2.82

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77

Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes. Cell Calcium (1987) 2.75

Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes (2002) 2.74

Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol (2003) 2.62

The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria. J Biol Chem (2005) 2.00

Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis. Gastroenterology (2003) 1.91

Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology (2008) 1.74

Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology (2007) 1.73

Multiphoton imaging can be used for microscopic examination of intact human gastrointestinal mucosa ex vivo. Clin Gastroenterol Hepatol (2007) 1.56

Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem (2002) 1.53

c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem (2007) 1.52

Nucleoplasmic calcium is required for cell proliferation. J Biol Chem (2007) 1.34

The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology (2002) 1.25

The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J Biol Chem (2005) 1.24

Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini. Gastroenterology (2002) 1.24

The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci U S A (2005) 1.23

Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology (2002) 1.11

Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin. Am J Physiol Gastrointest Liver Physiol (2007) 1.07

The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J Biol Chem (2007) 1.05

Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05

Succinate is a paracrine signal for liver damage. J Hepatol (2007) 1.04

Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology (2010) 1.01

Lipid rafts establish calcium waves in hepatocytes. Gastroenterology (2007) 1.01

Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression. Cell Calcium (2009) 1.00

Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium (2005) 0.98

Molecular basis for calcium signaling in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.97

High-definition confocal endomicroscopy of the common bile duct. J Clin Gastroenterol (2012) 0.97

Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference. Hepatology (2008) 0.96

The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma. Cell Calcium (2010) 0.95

Molecular basis for pacemaker cells in epithelia. J Biol Chem (2002) 0.95

Sevoflurane for interventional neuroradiology procedures is associated with more rapid early recovery than propofol. Can J Anaesth (2004) 0.94

Confocal endomicroscopic examination of malignant biliary strictures and histologic correlation with lymphatics. J Clin Gastroenterol (2011) 0.94

Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway. Biochem Biophys Res Commun (2011) 0.93

Cytosolic calcium regulates liver regeneration in the rat. Hepatology (2010) 0.93

Confocal colonoscopy: more than skin deep. Gastroenterology (2004) 0.92

Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology (2011) 0.92

The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology (2013) 0.92

Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol (2011) 0.91

Calcium signaling in the nucleus. Can J Physiol Pharmacol (2006) 0.90

Hormonal regulation of nuclear permeability. J Biol Chem (2006) 0.88

Expression and regulation of gap junctions in rat cholangiocytes. Hepatology (2002) 0.88

Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis. Hepatology (2011) 0.86

The plasmodium receptor for activated C kinase protein inhibits Ca(2+) signaling in mammalian cells. Biochem Biophys Res Commun (2009) 0.86

Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling. J Biol Chem (2010) 0.85

Needle-based confocal laser endomicroscopy to assess liver histology in vivo. Gastrointest Endosc (2010) 0.85

Endotoxin unmasks the role of gap junctions in the liver. Biochem Biophys Res Commun (2004) 0.81

The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves. Neurosignals (2011) 0.81

Regulation of the type III InsP(3) receptor by InsP(3) and calcium. Biochem Biophys Res Commun (2002) 0.79

Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line. Cell Calcium (2005) 0.79

The role of inositol 1,4,5-trisphosphate receptors in the regulation of bile secretion in health and disease. Biochem Biophys Res Commun (2004) 0.78

Evaluation of Barrett esophagus by multiphoton microscopy. Arch Pathol Lab Med (2014) 0.77

Anaesthetic and ICU management of aneurysmal subarachnoid haemorrhage: a survey of European practice. Eur J Anaesthesiol (2015) 0.77

Of sweat and bile. J Hepatol (2002) 0.75

Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Cell Mol Gastroenterol Hepatol (2016) 0.75

Faster than a speeding bullet. Hepatology (2014) 0.75

Portal hypertension: from the patient to the molecule and back: a symposium honoring Roberto J. Groszmann, MD. J Clin Gastroenterol (2007) 0.75

A multi-journal partnership to highlight joint first-authors of manuscripts. Hepatology (2015) 0.75

A multi-journal partnership to highlight joint first-authors of manuscripts. Gastrointest Endosc (2015) 0.75

A multi-journal partnership to highlight joint first-authors of manuscripts. Gastroenterology (2015) 0.75

Presentation of the AGA Distinguished Achievement Award to Henry J. Binder, MD. Gastroenterology (2005) 0.75

Journal of Clinical Gastroenterology. Introduction. J Clin Gastroenterol (2013) 0.75

Developing standardised advanced training in neuroanaesthesia: Results of a Europe-wide survey. Eur J Anaesthesiol (2017) 0.75