Published in J Biol Chem on December 11, 2007
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology (2008) 1.74
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Lett (2012) 1.73
Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41
The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem (2010) 1.36
Trafficking of receptor tyrosine kinases to the nucleus. Exp Cell Res (2008) 1.33
COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun (2010) 1.16
Expression of the c-Met Proteins in Malignant Skin Cancers. Ann Dermatol (2011) 1.09
PAX3 and SOX10 activate MET receptor expression in melanoma. Pigment Cell Melanoma Res (2010) 1.06
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. Lab Invest (2009) 1.04
Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem (2009) 1.03
Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem (2011) 0.98
The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma. Cell Calcium (2010) 0.95
Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology (2010) 0.94
Receptor tyrosine kinases in the nucleus. Cold Spring Harb Perspect Biol (2013) 0.93
Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus. PLoS One (2012) 0.93
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET. PLoS One (2012) 0.93
Cytosolic calcium regulates liver regeneration in the rat. Hepatology (2010) 0.93
Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway. Biochem Biophys Res Commun (2011) 0.93
EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell (2014) 0.92
P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells. Am J Physiol Cell Physiol (2010) 0.92
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology (2013) 0.92
Role of receptor tyrosine kinases and their ligands in glioblastoma. Cells (2014) 0.91
Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol (2011) 0.91
Tumor and circulating biomarkers in patients with second-line hepatocellular carcinoma from the randomized phase II study with tivantinib. Oncotarget (2016) 0.88
Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer. Mol Endocrinol (2014) 0.87
Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus. Cell Commun Signal (2013) 0.87
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol Cell Biol (2012) 0.86
Calcium signaling and the secretory activity of bile duct epithelia. Cell Calcium (2014) 0.84
Calcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes. Cell Calcium (2012) 0.83
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med (2016) 0.82
Nuclear calcium signaling: a cell within a cell. Braz J Med Biol Res (2008) 0.82
The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves. Neurosignals (2011) 0.81
Calcium signalling and liver regeneration. Int J Hepatol (2012) 0.81
Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2. Cell Death Dis (2014) 0.80
Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells. Mol Cell Proteomics (2010) 0.79
Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS J (2015) 0.79
Calcium signaling in the liver. Compr Physiol (2013) 0.78
Decoding calcium signaling across the nucleus. Physiology (Bethesda) (2014) 0.78
Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma. Oncotarget (2016) 0.78
Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland. Pathol Res Pract (2015) 0.78
Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology (2016) 0.77
SET domain-containing Protein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyltransferase involved in Breast Cancer Cell Proliferation. J Cancer Sci Ther (2013) 0.76
NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Sci Rep (2015) 0.76
Cytoplasmic-targeted parvalbumin blocks the proliferation of multipotent mesenchymal stromal cells in prophase. Stem Cell Res Ther (2013) 0.76
FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. Oncotarget (2016) 0.75
Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration. PLoS One (2016) 0.75
Effects of different ligands on epidermal growth factor receptor (EGFR) nuclear translocation. Biochem Biophys Res Commun (2016) 0.75
Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma. Mol Cancer Ther (2016) 0.75
Sequences within the C-terminus of the metabotropic glutamate receptor, mGluR5, are responsible for inner nuclear membrane localization. J Biol Chem (2017) 0.75
Effective implementation of novel MET pharmacodynamic assays in translational studies. Ann Transl Med (2017) 0.75
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer. Cancer Metastasis Rev (2016) 0.75
The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol (2000) 19.46
Liver regeneration. Science (1997) 12.80
Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol (2001) 7.22
Scatter factor/hepatocyte growth factor is essential for liver development. Nature (1995) 5.91
Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol (2006) 5.37
Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem (2006) 5.34
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (2001) 4.90
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature (2002) 3.99
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13
Cytosolic Ca2+ gradients triggering unidirectional fluid secretion from exocrine pancreas. Nature (1991) 3.10
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature (2002) 2.99
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature (1997) 2.93
Endocytosis and signaling. an inseparable partnership. Cell (2001) 2.79
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol (1989) 2.78
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol (2003) 2.62
The "Gab" in signal transduction. Trends Cell Biol (2003) 2.52
Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene (2000) 2.52
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. Anal Biochem (2003) 2.15
Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J Cell Biol (2001) 2.04
The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria. J Biol Chem (2005) 2.00
Nuclear lipid signalling. Nat Rev Mol Cell Biol (2003) 2.00
ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope. Cell (1995) 1.97
Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol (2000) 1.97
Calcium release from the nucleus by InsP3 receptor channels. Neuron (1995) 1.86
Transmitter-evoked local calcium release stabilizes developing dendrites. Nature (2002) 1.70
Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem (2002) 1.61
Micromolar and submicromolar Ca2+ spikes regulating distinct cellular functions in pancreatic acinar cells. EMBO J (1997) 1.59
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem (2002) 1.53
Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci U S A (1992) 1.48
Nuclear and cytosolic calcium are regulated independently. Proc Natl Acad Sci U S A (2003) 1.46
Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest (1993) 1.44
Signalling shortcuts: cell-surface receptors in the nucleus? Nat Rev Mol Cell Biol (2002) 1.39
Stereospecific inositol 1,4,5-[32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus. Proc Natl Acad Sci U S A (1990) 1.38
Nucleoplasmic calcium is required for cell proliferation. J Biol Chem (2007) 1.34
Vasopressin receptors. Trends Endocrinol Metab (2000) 1.26
Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. J Biol Chem (2004) 1.26
The developing role of receptors and adaptors. Nat Rev Cancer (2006) 1.21
The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J Biol Chem (2007) 1.05
Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology (1999) 1.02
Lipid rafts establish calcium waves in hepatocytes. Gastroenterology (2007) 1.01
Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology (1992) 1.00
Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts. J Cell Sci (1993) 0.99
ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation. J Biol Chem (2004) 0.97
Molecular basis for pacemaker cells in epithelia. J Biol Chem (2002) 0.95
Tyrosine phosphorylation of phospholipase C gamma in c-met/HGF receptor-stimulated hepatocytes: comparison with HepG2 hepatocarcinoma cells. Biochem Biophys Res Commun (1993) 0.92
Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets. Am J Physiol (1992) 0.88
Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes. J Cell Physiol (1993) 0.83
Insulin selectively stimulates nuclear phosphoinositide-specific phospholipase C (PI-PLC) beta1 activity through a mitogen-activated protein (MAP) kinase-dependent serine phosphorylation. FEBS Lett (2000) 0.82
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell (2006) 10.06
Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell (2010) 4.47
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A (2006) 3.74
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol (2006) 3.56
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med (2011) 3.09
Phosphatidylinositol 4-kinases: old enzymes with emerging functions. Trends Cell Biol (2006) 3.06
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05
Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex. J Biol Chem (2007) 3.02
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol (2003) 2.62
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
Dual regulation of TRPV1 by phosphoinositides. J Neurosci (2007) 2.48
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol Biol Cell (2005) 2.39
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell (2007) 2.15
The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria. J Biol Chem (2005) 2.00
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest (2004) 2.00
Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron (2006) 1.98
Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis. Gastroenterology (2003) 1.91
Activation of STIM1-Orai1 involves an intramolecular switching mechanism. Sci Signal (2010) 1.89
Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners. J Cell Sci (2005) 1.80
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J Biol Chem (2002) 1.78
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell (2007) 1.77
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab (2006) 1.76
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching. Nat Neurosci (2010) 1.74
Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology (2008) 1.74
Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem (2005) 1.74
Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology (2007) 1.73
Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem (2002) 1.61
Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology (2014) 1.60
Multiphoton imaging can be used for microscopic examination of intact human gastrointestinal mucosa ex vivo. Clin Gastroenterol Hepatol (2007) 1.56
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem (2002) 1.53
SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway. Mol Cell Biol (2004) 1.53
Live cell imaging of phosphoinositide dynamics with fluorescent protein domains. Biochim Biophys Acta (2006) 1.53
Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem (2006) 1.52
A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev Cell (2011) 1.50
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metab (2012) 1.46
The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production. Biomaterials (2004) 1.45
Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. J Cell Biol (2002) 1.43
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem (2004) 1.42
Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. Proc Natl Acad Sci U S A (2010) 1.42
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
Nucleoplasmic calcium is required for cell proliferation. J Biol Chem (2007) 1.34
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes (2005) 1.33
A membrane capture assay for lipid kinase activity. Nat Protoc (2007) 1.32
Structural determinants of Ras-Raf interaction analyzed in live cells. Mol Biol Cell (2002) 1.31
Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol (2009) 1.31
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci (2012) 1.29
The vesicular acetylcholine transporter is required for neuromuscular development and function. Mol Cell Biol (2009) 1.27
The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology (2002) 1.25
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Targeted expression of the inositol 1,4,5-triphosphate receptor (IP3R) ligand-binding domain releases Ca2+ via endogenous IP3R channels. Proc Natl Acad Sci U S A (2005) 1.24
The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals. J Biol Chem (2005) 1.24
Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini. Gastroenterology (2002) 1.24
The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci U S A (2005) 1.23
Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol (2009) 1.23
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis. J Cell Physiol (2004) 1.21
Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements. J Am Chem Soc (2009) 1.21
STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. J Biol Chem (2008) 1.20
Endocytic intermediates involved with the intracellular trafficking of a fluorescent cellular prion protein. J Biol Chem (2002) 1.16
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem (2014) 1.15
Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains. Pflugers Arch (2007) 1.14
The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation. Mol Cell Biol (2005) 1.14
Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology (2002) 1.11
Live cell imaging of phosphoinositides with expressed inositide binding protein domains. Methods (2008) 1.11
SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol (2006) 1.10
Nuclear Ca2+ regulates cardiomyocyte function. Cell Calcium (2008) 1.09
G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Mol Biol Cell (2008) 1.08
Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin. Am J Physiol Gastrointest Liver Physiol (2007) 1.07
Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol (2009) 1.07
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry (2008) 1.06
The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves. J Biol Chem (2007) 1.05
Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas. Int J Cancer (2006) 1.05
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol (2010) 1.05
Plant O-hydroxyproline arabinogalactans are composed of repeating trigalactosyl subunits with short bifurcated side chains. J Biol Chem (2010) 1.04
Succinate is a paracrine signal for liver damage. J Hepatol (2007) 1.04