The Bcl-2 protein family: arbiters of cell survival.

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev (2000) 8.35

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol (2000) 5.85

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell (2008) 5.67

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev (2001) 5.66

A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev (2000) 5.65

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56

EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol (2008) 5.46

Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J (1999) 5.10

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci U S A (1999) 3.45

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol (2000) 3.34

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol (1999) 3.30

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev (1999) 3.25

Mechanisms of apoptosis. Am J Pathol (2000) 3.23

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc Natl Acad Sci U S A (1999) 3.22

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med (2001) 3.18

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A (2001) 3.16

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J Cell Biol (2001) 3.09

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol (1999) 2.93

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci U S A (1999) 2.83

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev (1999) 2.82

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol (2001) 2.80

Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc Natl Acad Sci U S A (2005) 2.77

Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (1999) 2.77

The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med (2000) 2.67

Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A (2001) 2.60

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. Curr Cancer Drug Targets (2011) 2.58

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol (2000) 2.53

Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47

Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J Virol (2002) 2.41

Transcriptional analysis of human survivin gene expression. Biochem J (1999) 2.39

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proc Natl Acad Sci U S A (1999) 2.32

In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J (2004) 2.30

Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut (2002) 2.26

Characterization of molecular recognition features, MoRFs, and their binding partners. J Proteome Res (2007) 2.23

The IRF-3 transcription factor mediates Sendai virus-induced apoptosis. J Virol (2000) 2.13

Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death Differ (2002) 2.13

Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol (2000) 2.10

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization. J Cell Biol (2000) 2.07

Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol Cell Biol (2000) 2.07

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A (2000) 2.06

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J (2000) 2.06

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Res (2006) 2.03

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol (2001) 2.03

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). Proc Natl Acad Sci U S A (1999) 1.99

The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. J Exp Med (1999) 1.98

Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J (2006) 1.97

Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J Am Chem Soc (2006) 1.93

Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res (2008) 1.92

Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut (2001) 1.92

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis (2010) 1.87

Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell (2000) 1.87

A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell (2013) 1.84

Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol (2000) 1.83

The insulin-like growth factor (IGF)-I E-peptides are required for isoform-specific gene expression and muscle hypertrophy after local IGF-I production. J Appl Physiol (1985) (2010) 1.83

Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res (2008) 1.79

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol (2004) 1.77

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J (2004) 1.77

Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J (2007) 1.76

Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis. Infect Immun (2004) 1.75

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. Mol Cell Biol (2004) 1.74

In stent restenosis: bane of the stent era. J Clin Pathol (2006) 1.71

Abrogation of disease development in plants expressing animal antiapoptotic genes. Proc Natl Acad Sci U S A (2001) 1.70

Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70

High aldehyde dehydrogenase activity: a novel functional marker of murine prostate stem/progenitor cells. Stem Cells (2009) 1.67

Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. Nanomedicine (Lond) (2008) 1.67

Mechanism of action for N-substituted benzamide-induced apoptosis. Br J Cancer (2002) 1.66

Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death. J Virol (1999) 1.64

Photodynamic therapy with the phthalocyanine photosensitizer Pc 4: the case experience with preclinical mechanistic and early clinical-translational studies. Toxicol Appl Pharmacol (2007) 1.64

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21. Mol Cell Biol (2000) 1.63

Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Mol Cell Biol (2001) 1.61

Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther (2003) 1.61

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A (2000) 1.60

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol (2001) 1.57

Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin. EMBO J (2002) 1.57

A caspase cascade regulating developmental axon degeneration. J Neurosci (2012) 1.57

Protein kinase Cepsilon makes the life and death decision. Cell Signal (2007) 1.57

p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci U S A (1999) 1.56

Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell (2012) 1.55

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood (2001) 1.54

Mitochondria: pharmacological manipulation of cell death. J Clin Invest (2005) 1.54

Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer (2003) 1.54

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus. Proc Natl Acad Sci U S A (2002) 1.52

The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nat Cell Biol (2009) 1.51

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A (2002) 1.51

Protein secretion and membrane insertion systems in gram-negative bacteria. J Membr Biol (2007) 1.51

Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J Cell Biol (2007) 1.50

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L). J Cell Biol (2000) 1.50

Regulated cell death in AKI. J Am Soc Nephrol (2014) 1.50

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J (2001) 1.50

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (1988) 14.66

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56

The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell (1991) 8.27

Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J (1998) 7.17

Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours. EMBO J (1983) 5.93

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature (1990) 5.63

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci U S A (1991) 4.72

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J (1995) 4.68

Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell (1984) 4.41

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell (1994) 4.22

The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell (1986) 3.72

Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene. EMBO J (1985) 3.68

Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. Proc Natl Acad Sci U S A (1983) 3.40

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell (1993) 3.09

Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci (2001) 3.03

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell (2001) 3.03

Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNA. Nature (1975) 2.97

Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes. Cell (1980) 2.89

Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv Cancer Res (1986) 2.84

Nucleotide sequence of N-formyl-methionyl-transfer RNA. Nature (1968) 2.82

Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines. Proc Natl Acad Sci U S A (1980) 2.77

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene (1997) 2.70

Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange. Cell (1984) 2.60

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines. Proc Natl Acad Sci U S A (1980) 2.57

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J (1997) 2.44

A very large repeating unit of mouse DNA containing the 18S, 28S and 5.8S rRNA genes. Cell (1977) 2.42

Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations. Nature (1985) 2.19

Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci U S A (1982) 2.16

Transgenic models of tumor development. Science (1991) 2.16

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J (1989) 2.13

Translation of immunoglobulin mRNAs in a wheat germ cell-free system. Mol Biol Rep (1974) 2.11

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J (1990) 2.00

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol (2011) 1.98

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression. Nature (1980) 1.96

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci U S A (1998) 1.95

Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes. J Mol Appl Genet (1981) 1.93

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature (1994) 1.88

bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene (1996) 1.87

Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Curr Top Microbiol Immunol (1990) 1.86

Molecular cloning of seven mouse immunoglobulin kappa chain messenger ribonucleic acids. Biochemistry (1980) 1.82

Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Proc Natl Acad Sci U S A (1990) 1.80

Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes. J Virol (1988) 1.75

Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain. Proc Natl Acad Sci U S A (1980) 1.73

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. Proc Natl Acad Sci U S A (1979) 1.71

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J (1998) 1.66

N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J (1989) 1.65

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J (1993) 1.61

Molecular cloning of mouse immunoglobulin heavy chain messenger ribonucleic acids coding for mu, alpha, gamma 1, gamma 2a, and gamma 3 chains. Biochemistry (1980) 1.60

Interchromosomal recombination of the cellular oncogene c-myc with the immunoglobulin heavy chain locus in murine plasmacytomas is a reciprocal exchange. EMBO J (1983) 1.57

The modified 5'-terminal sequences in messenger RNA of mouse myeloma cells. J Mol Biol (1975) 1.56

Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma. Cell (1985) 1.56

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene (1993) 1.51

Variant (6 ; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin kappa gene but far from the myc oncogene. Nature (1985) 1.45

Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses. Mol Biol Med (1987) 1.42

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bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia. Oncogene Res (1988) 1.41

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Untranslated nucleotide sequence at the 5'-end of R17 bacteriophage RNA. Nature (1970) 1.33

An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. EMBO J (1990) 1.32

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc Natl Acad Sci U S A (1994) 1.32

The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann N Y Acad Sci (2000) 1.31

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow. Blood (1993) 1.30

The nucleotide sequence of N-formyl-methionyl-transfer RNA. Products of complete digestion with ribonuclease T-1 and pancreatic ribonuclease and derivation of their sequences. Eur J Biochem (1969) 1.29

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1. Proc Natl Acad Sci U S A (1999) 1.27

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector. Oncogene (1999) 1.24

Generation of altered transcripts by retroviral insertion within the c-myb gene in two murine monocytic leukemias. J Virol (1987) 1.24

Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival. EMBO J (1996) 1.22

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A bcr-v-abl oncogene induces lymphomas in transgenic mice. Mol Cell Biol (1989) 1.10

Oncogene cooperation in lymphocyte transformation: malignant conversion of E mu-myc transgenic pre-B cells in vitro is enhanced by v-H-ras or v-raf but not v-abl. Mol Cell Biol (1989) 1.08

bcr-abl-Induced cell lines can switch from mast cell to erythroid or myeloid differentiation in vitro. Blood (1992) 1.01

Lymphomagenesis in E mu-myc transgenic mice can involve ras mutations. Oncogene (1989) 1.00

Cloned embryonic DNA sequences flanking the mouse immunoglobulin C gamma 3 and C gamma 1 genes. Nucleic Acids Res (1980) 1.00

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Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature. Oncogene (2011) 0.87

Recombination events near the immunoglobulin Cmu gene join variable and constant region genes, switch heavy-chain expression, or inactivate the locus. Biochemistry (1981) 0.87

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