Published in J Immunol on June 03, 2013
'MHC-I-opathy'-unified concept for spondyloarthritis and Behçet disease. Nat Rev Rheumatol (2015) 1.99
Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis. Proc Natl Acad Sci U S A (2014) 1.90
ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations. Proc Natl Acad Sci U S A (2017) 1.10
αβ T cell receptors as predictors of health and disease. Cell Mol Immunol (2015) 1.01
Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands. J Biol Chem (2013) 0.98
The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis. Appl Clin Genet (2014) 0.96
The immunogenetics of Behçet's disease: A comprehensive review. J Autoimmun (2015) 0.91
Both rare and common ERAP1 allotypes have distinct functionality defined by polymorphic context and are important in AS association. Proc Natl Acad Sci U S A (2017) 0.91
Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens. Autoimmunity (2013) 0.90
A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition. Front Oncol (2014) 0.84
Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population. PLoS One (2014) 0.82
Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics. Curr Opin Rheumatol (2015) 0.82
Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation. Curr Opin Rheumatol (2015) 0.80
Genetic architectures of seropositive and seronegative rheumatic diseases. Nat Rev Rheumatol (2015) 0.79
A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers. Ann Rheum Dis (2016) 0.79
ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing. Sci Rep (2016) 0.78
ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses. Int Immunol (2014) 0.78
Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells. J Innate Immun (2015) 0.76
The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion. Mol Cell Proteomics (2017) 0.76
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism. Oncoimmunology (2017) 0.76
Single Nucleotide Polymorphisms of the ERAP1 Gene and Risk of NSCLC: A Comparison of Genetically Distant Populations, Chinese and Caucasian. Arch Immunol Ther Exp (Warsz) (2017) 0.75
Antigen processing and immune regulation in the response to tumours. Immunology (2016) 0.75
Connecting genetic risk to disease end points through the human blood plasma proteome. Nat Commun (2017) 0.75
The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from antiviral protection to Spondyloarthritis. Clin Exp Immunol (2017) 0.75
Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens. Sci Rep (2017) 0.75
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature (2002) 3.72
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol (2005) 3.39
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol (2006) 2.62
The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A (2005) 2.47
Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature (1992) 2.27
The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol (2005) 2.24
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J (2001) 2.09
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci U S A (2006) 1.91
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med (2006) 1.79
Characterizing the N-terminal processing motif of MHC class I ligands. J Immunol (2008) 1.68
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci U S A (2011) 1.64
ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat Immunol (2001) 1.56
Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. Arthritis Rheum (2009) 1.46
ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity (2006) 1.43
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. Ann Rheum Dis (2009) 1.42
The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum. J Immunol (2009) 1.30
The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway. Mol Cell (2003) 1.21
Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing. Cancer Res (2011) 1.16
Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo. Mol Cell Proteomics (2012) 1.15
Genetic variation of antigen processing machinery components and association with cervical carcinoma. Genes Chromosomes Cancer (2007) 1.11
Disulfide bond engineering to trap peptides in the MHC class I binding groove. J Immunol (2007) 1.02
The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes. J Immunol (1995) 0.99
Investigating the genetic association between ERAP1 and spondyloarthritis. Ann Rheum Dis (2012) 0.95
A functional variant in ERAP1 predisposes to multiple sclerosis. PLoS One (2012) 0.93
Endoplasmic reticulum aminopeptidase associated with antigen processing regulates quality of processed peptides presented by MHC class I molecules. J Immunol (2008) 0.90
The amount of recycled crust in sources of mantle-derived melts. Science (2007) 3.93
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol (2006) 2.62
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
Origin of nucleosynthetic isotope heterogeneity in the solar protoplanetary disk. Science (2009) 2.17
Optimization of the MHC class I peptide cargo is dependent on tapasin. Immunity (2002) 2.02
Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling. Chem Rev (2002) 2.02
The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review. Rheumatology (Oxford) (2009) 1.99
Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol (2002) 1.88
Outcome and treatment of Bartonella endocarditis. Arch Intern Med (2003) 1.74
Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci U S A (2010) 1.72
Tungsten isotope evidence that mantle plumes contain no contribution from the Earth's core. Nature (2004) 1.66
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity (2002) 1.54
Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling. Eur J Immunol (2003) 1.53
Tapasin enhances MHC class I peptide presentation according to peptide half-life. Proc Natl Acad Sci U S A (2004) 1.49
Uricosuric medications for chronic gout. Cochrane Database Syst Rev (2014) 1.43
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Ann Rheum Dis (2013) 1.39
Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review. Rheumatology (Oxford) (2010) 1.34
The tungsten isotopic composition of the Earth's mantle before the terminal bombardment. Nature (2011) 1.23
Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO J (2009) 1.23
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles. Proc Natl Acad Sci U S A (2005) 1.22
The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules. EMBO J (2002) 1.14
Retracted Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules. Mol Biol Cell (2008) 1.14
Contemporary treatment principles for early rheumatoid arthritis: a consensus statement. Rheumatology (Oxford) (2009) 1.14
Anti-TNF-induced lupus. Rheumatology (Oxford) (2009) 1.12
Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. J Immunol (2008) 1.12
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc Natl Acad Sci U S A (2013) 1.11
ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity. J Biol Chem (2009) 1.11
Transplantation tolerance induced by intranasal administration of HY peptides. Blood (2004) 1.11
Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis. J Rheumatol (2008) 1.05
Role of immunoproteasomes in cross-presentation. J Immunol (2006) 1.05
Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. Arthritis Rheumatol (2014) 1.00
Prognostic indicators of foot-related disability in patients with rheumatoid arthritis: results of a prospective three-year study. Arthritis Care Res (Hoboken) (2012) 0.99
Molecular machinations of the MHC-I peptide loading complex. Curr Opin Immunol (2008) 0.98
Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologist. J Foot Ankle Res (2008) 0.96
The clinical importance of ultrasound detectable forefoot bursae in rheumatoid arthritis. Rheumatology (Oxford) (2009) 0.96
Mortality in Wegener's granulomatosis: a bimodal pattern. Rheumatology (Oxford) (2010) 0.96
A peptide filtering relation quantifies MHC class I peptide optimization. PLoS Comput Biol (2011) 0.95
Older driver failures of attention at intersections: using change blindness methods to assess turn decision accuracy. Hum Factors (2005) 0.95
Synthesis and in vitro evaluation of alpha-GalCer epimers. ChemMedChem (2008) 0.95
The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells. J Immunol (2006) 0.94
The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate. J Biol Chem (2006) 0.93
A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins. J Biol Chem (2013) 0.92
Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility. FASEB J (2011) 0.92
Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative. Rheumatology (Oxford) (2012) 0.92
Assembly and export of MHC class I peptide ligands. Curr Opin Immunol (2003) 0.92
Induction of protective antitumor immunity through attenuation of ERAAP function. J Immunol (2013) 0.92
Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses. Breast Cancer Res (2007) 0.92
Allopurinol for chronic gout. Cochrane Database Syst Rev (2014) 0.91
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis). Cochrane Database Syst Rev (2011) 0.91
Safety of nonsteroidal antiinflammatory drugs and/or paracetamol in people receiving methotrexate for inflammatory arthritis: a Cochrane systematic review. J Rheumatol Suppl (2012) 0.91
Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: a twelve-month investigation. Arthritis Care Res (Hoboken) (2010) 0.89
Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes. Eur J Immunol (2008) 0.89
The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice. Novartis Found Symp (2004) 0.87
Direct deprotected glycosyl-asparagine ligation. Chem Commun (Camb) (2006) 0.85
The processing of antigens delivered as DNA vaccines. Immunol Rev (2004) 0.85
Comparison of traditional and interactive teaching methods in a UK emergency department. Eur J Emerg Med (2009) 0.83
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing. Proc Natl Acad Sci U S A (2007) 0.83
Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope. J Immunol (2009) 0.83
Should morphine dosing be weight based for analgesia in the emergency department? J Opioid Manag (2012) 0.82
CD8+ T-cell cross-competition is governed by peptide-MHC class I stability. Eur J Immunol (2011) 0.81
Differentiation of Agaricus species and other homobasidiomycetes based on volatile production patterns using an electronic nose system. Mycol Res (2003) 0.81
Mousepox detected in a research facility: case report and failure of mouse antibody production testing to identify Ectromelia virus in contaminated mouse serum. Comp Med (2009) 0.81
Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity. Cochrane Database Syst Rev (2011) 0.80
A tunneled and turned-over nasolabial flap for reconstruction of full thickness nasal ala defects. Dermatol Surg (2010) 0.80
Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study. Dermatol Surg (2004) 0.80
Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000. Org Lett (2008) 0.80
Intravenous pulses of methylprednisolone for systemic lupus erythematosus. Semin Arthritis Rheum (2003) 0.80
Further experience with the use of 6-thioguanine in patients with Crohn's disease. Inflamm Bowel Dis (2008) 0.80
Age-related differences in propofol dosing for procedural sedation in the Emergency Department. J Emerg Med (2013) 0.80
IL-6 inhibition and infection: treating patients with tocilizumab. Rheumatology (Oxford) (2011) 0.80
Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells. Chemistry (2004) 0.79
The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen. Immunology (2012) 0.79
The 'chop-and-change' of MHC class I assembly. Nat Immunol (2006) 0.79
Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine. Regen Med (2012) 0.78
The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000. ChemMedChem (2009) 0.78
ERAP1 in the pathogenesis of ankylosing spondylitis. Immunol Res (2014) 0.78
Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity. Ther Adv Musculoskelet Dis (2012) 0.78
Psychosis and catatonia as a first presentation of antiphospholipid syndrome. Br J Psychiatry (2009) 0.78
Induction dose of propofol for pediatric patients undergoing procedural sedation in the emergency department. Pediatr Emerg Care (2012) 0.78
Lifestyle interventions for acute gout. Cochrane Database Syst Rev (2013) 0.77
Lifestyle interventions for chronic gout. Cochrane Database Syst Rev (2013) 0.77
Pain pharmacotherapy in patients with inflammatory arthritis and concurrent cardiovascular or renal disease: a Cochrane systematic review. J Rheumatol Suppl (2012) 0.77
Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk. Oncoimmunology (2012) 0.77
Interventions for tophi in gout. Cochrane Database Syst Rev (2014) 0.76
Idiopathic inflammatory myositis-associated interstitial lung disease: ethnicity differences and lung function trends in a British cohort. Rheumatology (Oxford) (2012) 0.76
The role of the emergency pharmacist in trauma resuscitation. J Pharm Pract (2011) 0.76
Study of infliximab treatment in asthma. Am J Respir Crit Care Med (2007) 0.76
Earth science: Restoration of the noble gases. Nature (2009) 0.75
Earth science: unleaded high-performance. Nature (2005) 0.75
Planetary science: Galvanized lunacy. Nature (2012) 0.75
Earth science: silicon-enhanced core. Nature (2007) 0.75
Mohs surgery in Australia: a survey of work practices. Australas J Dermatol (2011) 0.75
Immunogenicity of calreticulin-bound murine leukemia virus glycoprotein gp90. Adv Exp Med Biol (2005) 0.75
The multidisciplinary management of non-melanoma conchal bowl skin cancer. Australas J Dermatol (2012) 0.75