Putting GWAS to the functional test: NR5A2 and pancreatic cancer risk.

Nuclear receptors and pathogenesis of pancreatic cancer. World J Gastroenterol (2014) 0.79

Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol (2016) 0.78

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis. Gut (2013) 1.43

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40

Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89

Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48

Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35

Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle (2009) 1.20

Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development (2006) 1.16

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development (2009) 1.11

Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell (2012) 1.09

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06

β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98

Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci (2013) 0.88

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development (2013) 0.87

Notch signaling: where pancreatic cancer and differentiation meet? Gastroenterology (2009) 0.83