Published in Cell Cycle on June 15, 2009
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell (2011) 3.47
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72
Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther (2013) 1.96
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta (2010) 1.59
Role of STRAP in regulating GSK3β function and Notch3 stabilization. Cell Cycle (2011) 1.54
Chemoprevention strategies for pancreatic cancer. Nat Rev Gastroenterol Hepatol (2010) 1.38
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. Cancer Lett (2013) 1.22
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways. PLoS One (2011) 1.11
Notch signaling proteins: legitimate targets for cancer therapy. Curr Protein Pept Sci (2010) 0.98
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
Regeneration and repair of the exocrine pancreas. Annu Rev Physiol (2014) 0.94
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. Oncotarget (2011) 0.89
Bmi1 is required for regeneration of the exocrine pancreas in mice. Gastroenterology (2012) 0.88
A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma. Invest New Drugs (2014) 0.88
PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis. Cancer Res (2013) 0.86
Novel strategies targeting cancer stem cells through phytochemicals and their analogs. Drug Deliv Transl Res (2013) 0.85
Pathogenesis of pancreatic cancer: lessons from animal models. Toxicol Pathol (2013) 0.84
[New insights into the origin of pancreatic cancer. Role of atypical flat lesions in pancreatic carcinogenesis]. Pathologe (2012) 0.83
Ethanol administration impairs pancreatic repair after injury. Pancreas (2012) 0.83
Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma. Oncol Lett (2014) 0.83
Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PLoS One (2014) 0.82
Molecular mechanism underlying lymphatic metastasis in pancreatic cancer. Biomed Res Int (2014) 0.82
The roles of FOXM1 in pancreatic stem cells and carcinogenesis. Mol Cancer (2013) 0.82
KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations. Genes Cancer (2011) 0.81
Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. Semin Immunopathol (2012) 0.80
Leveraging Mechanisms Governing Pancreatic Tumorigenesis To Reduce Pancreatic Cancer Mortality. Trends Endocrinol Metab (2016) 0.76
Use of panitumumab in the treatment of acinar cell carcinoma of the pancreas: A case report. Oncol Lett (2012) 0.75
Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward. Int J Mol Sci (2017) 0.75
Differentiation and Inflammation: 'Best Enemies' in Gastrointestinal Carcinogenesis. Trends Cancer (2016) 0.75
Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Pancreatic cancer. Annu Rev Pathol (2008) 6.96
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res (2006) 4.83
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology (2005) 3.56
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol (2007) 2.87
Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature (1985) 2.77
Developmental biology of the pancreas: a comprehensive review. Dev Biol (2008) 2.59
Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res (2009) 2.43
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science (1987) 2.35
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell (1987) 2.32
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res (2003) 2.28
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res (2007) 2.26
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A (2007) 2.18
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Res (2003) 1.89
Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc Natl Acad Sci U S A (1991) 1.72
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res (2006) 1.69
PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res (2006) 1.63
Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer. Am J Physiol Gastrointest Liver Physiol (2004) 1.61
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev (2003) 1.43
The ultrastructural organization of the rat exocrine pancreas. III. Intralobular vessels and nerves. J Ultrastruct Res (1962) 1.26
Dissecting the cellular origins of pancreatic cancer. Cell Cycle (2006) 1.02
Modelling oncogenic Ras/Raf signalling in the mouse. Curr Opin Genet Dev (2009) 1.02
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41
Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development (2006) 1.16
Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development (2009) 1.11
Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell (2012) 1.09
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci (2013) 0.88
Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development (2013) 0.87
Notch signaling: where pancreatic cancer and differentiation meet? Gastroenterology (2009) 0.83
Putting GWAS to the functional test: NR5A2 and pancreatic cancer risk. Gut (2013) 0.76