Published in Proc Natl Acad Sci U S A on August 17, 2005
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Notch signaling controls liver development by regulating biliary differentiation. Development (2009) 2.93
Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep (2010) 2.93
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development (2011) 2.45
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest (2010) 2.42
Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium. Am J Physiol Gastrointest Liver Physiol (2009) 2.21
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol (2006) 1.71
Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol (2008) 1.66
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation (2012) 1.66
Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA (2008) 1.66
SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp Cell Res (2009) 1.64
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat Methods (2013) 1.58
Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology (2010) 1.52
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal (2010) 1.50
A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal (2015) 1.47
Intestinal development and differentiation. Exp Cell Res (2011) 1.44
Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol (2010) 1.41
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. BMC Cancer (2017) 1.38
Small intestinal stem cell markers. J Anat (2008) 1.32
Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology (2012) 1.32
DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev (2014) 1.31
Intestinal stem cell function in Drosophila and mice. Curr Opin Genet Dev (2012) 1.30
Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J Clin Invest (2011) 1.28
Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A (2010) 1.25
Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem (2011) 1.24
Reparative inflammation takes charge of tissue regeneration. Nature (2016) 1.21
Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med (2011) 1.20
The pathogenic role of Notch activation in podocytes. Nephron Exp Nephrol (2009) 1.17
Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell (2012) 1.16
Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14
Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis. Gastroenterology (2008) 1.12
Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci (2010) 1.09
Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development (2011) 1.07
Intestinal mucosal atrophy and adaptation. World J Gastroenterol (2012) 1.06
Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol (2009) 1.04
Notch: architect, landscaper, and guardian of the intestine. Gastroenterology (2011) 1.03
Notch signaling regulates gastric antral LGR5 stem cell function. EMBO J (2015) 0.99
Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear. J Neurosci (2013) 0.99
Generation of L cells in mouse and human small intestine organoids. Diabetes (2013) 0.98
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease. Br J Pharmacol (2009) 0.98
Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem (2013) 0.98
Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism. Dev Biol (2011) 0.96
Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation. Diabetes Obes Metab (2011) 0.96
Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. Proc Natl Acad Sci U S A (2007) 0.93
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther (2010) 0.91
Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol (2012) 0.91
Molecular mechanisms of Barrett's esophagus. Dig Dis Sci (2011) 0.89
Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis. Dev Biol (2011) 0.89
Targeting development of incretin-producing cells increases insulin secretion. J Clin Invest (2014) 0.88
Biology of Barrett's esophagus and esophageal adenocarcinoma. Gastrointest Endosc Clin N Am (2011) 0.88
Generating human intestinal tissues from pluripotent stem cells to study development and disease. EMBO J (2015) 0.88
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun (2016) 0.88
Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration. Dev Biol (2015) 0.87
Recombination signal binding protein for Ig-κJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression. J Am Soc Nephrol (2014) 0.87
NOTCH Signaling and ATOH1 in Colorectal Cancers. Curr Colorectal Cancer Rep (2011) 0.86
Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. Int J Colorectal Dis (2013) 0.85
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium. Cell Death Dis (2015) 0.85
Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci (2010) 0.85
The Jagged-1/Notch-1/Hes-1 pathway is involved in intestinal adaptation in a massive small bowel resection rat model. Dig Dis Sci (2013) 0.85
ROS, Notch, and Wnt signaling pathways: crosstalk between three major regulators of cardiovascular biology. Biomed Res Int (2014) 0.84
Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. J Biomed Sci (2010) 0.84
Unraveling intestinal stem cell behavior with models of crypt dynamics. Integr Biol (Camb) (2014) 0.84
hnRNP I inhibits Notch signaling and regulates intestinal epithelial homeostasis in the zebrafish. PLoS Genet (2009) 0.84
Dishevelled limits Notch signalling through inhibition of CSL. Development (2012) 0.84
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
γ-Secretase inhibitor DAPT attenuates intimal hyperplasia of vein grafts by inhibition of Notch1 signaling. Lab Invest (2014) 0.81
The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury. PLoS One (2013) 0.81
Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance. PLoS One (2011) 0.81
Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365. Am J Physiol Gastrointest Liver Physiol (2011) 0.81
Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials. Biomed Res Int (2014) 0.81
Tumor biology and cancer therapy - an evolving relationship. Cell Commun Signal (2009) 0.80
The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J (2014) 0.80
Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Bone (2014) 0.80
Citrobacter Infection and Wnt signaling. Curr Colorectal Cancer Rep (2012) 0.79
Targeting Notch Signaling in Colorectal Cancer. Curr Colorectal Cancer Rep (2014) 0.79
Mini-review: Does Notch promote or suppress cancer? New findings and old controversies. Am J Clin Exp Urol (2015) 0.79
Signaling in cell differentiation and morphogenesis. Cold Spring Harb Perspect Biol (2012) 0.78
Notch regulation of gastrointestinal stem cells. J Physiol (2016) 0.78
Epigenetic regulation of the intestinal epithelium. Cell Mol Life Sci (2015) 0.78
Canonical Notch activation in osteocytes causes osteopetrosis. Am J Physiol Endocrinol Metab (2015) 0.77
Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development. PLoS One (2016) 0.76
Effects of Sex and Notch Signaling on the Osteocyte Cell Pool. J Cell Physiol (2016) 0.76
Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest (2016) 0.76
The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet (2015) 0.75
The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele. J Cell Biochem (2015) 0.75
Hairy and Enhancer of Split-related with YRPW Motif-Like (HeyL) is Dispensable for Bone Remodeling in Mice. J Cell Biochem (2016) 0.75
Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease. EMBO Mol Med (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Control of endodermal endocrine development by Hes-1. Nat Genet (2000) 7.71
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science (2001) 7.17
Z/AP, a double reporter for cre-mediated recombination. Dev Biol (1999) 6.88
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology (1999) 4.47
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem (2004) 4.27
Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell (2000) 3.87
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci (2004) 3.85
Notch regulation of lymphocyte development and function. Nat Immunol (2004) 3.39
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J (2002) 3.30
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22
Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development (2005) 2.53
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A (2003) 2.33
Genetic mosaic analysis based on Cre recombinase and navigated laser capture microdissection. Proc Natl Acad Sci U S A (2000) 2.26
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem (2003) 2.22
Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A (2002) 2.20
Live and let die in the intestinal epithelium. Curr Opin Cell Biol (2003) 1.85
Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns (2002) 1.72
Expression of notch receptors and ligands in the adult gut. J Histochem Cytochem (2004) 1.53
Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Curr Biol (2003) 1.46
Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated. Proc Natl Acad Sci U S A (1993) 1.14
Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants. Proc Natl Acad Sci U S A (1991) 0.98
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Retracted Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell (2013) 6.86
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (2005) 6.14
Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32
A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13
Extreme makeover: converting one cell into another. Cell Stem Cell (2008) 3.60
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A (2008) 3.40
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature (2007) 3.11
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10
A gene regulatory network in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.94
Endothelial signaling during development. Nat Med (2003) 2.83
Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev (2003) 2.58
Role of VEGF-A in vascularization of pancreatic islets. Curr Biol (2003) 2.56
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Insulin staining of ES cell progeny from insulin uptake. Science (2003) 2.46
Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (2003) 2.39
Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31
Single-cell transcript analysis of pancreas development. Dev Cell (2003) 2.11
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol (2012) 1.90
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89
Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol (2003) 1.89
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol (2007) 1.75
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature (2012) 1.64
How to make a functional β-cell. Development (2013) 1.58
Transcriptional dynamics of endodermal organ formation. Dev Dyn (2009) 1.58
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol (2010) 1.45
Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44
A simple tool to improve pluripotent stem cell differentiation. Nat Methods (2013) 1.42
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem (2004) 1.31
How to make beta cells? Curr Opin Cell Biol (2009) 1.31
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes (2002) 1.23
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21
Facultative endocrine progenitor cells in the adult pancreas. Cell (2008) 1.21
Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling. Cell Cycle (2009) 1.20
How important are adult stem cells for tissue maintenance? Cell Cycle (2004) 1.17
Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development (2006) 1.16
Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14
Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev (2006) 1.13
Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development (2009) 1.11
Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn (2008) 1.11
Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell (2012) 1.09
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife (2014) 1.08
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice. Dis Model Mech (2012) 0.98
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (2013) 0.96
Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96
Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci (2013) 0.88
Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development (2013) 0.87
Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol (2002) 0.86
Notch signaling: where pancreatic cancer and differentiation meet? Gastroenterology (2009) 0.83
Derivation of human embryonic stem cells by immunosurgery. J Vis Exp (2007) 0.82
The molecular biography of the cell. Cell (2005) 0.81
Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med (2016) 0.81
New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes (2013) 0.78
Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (2013) 0.77
Putting GWAS to the functional test: NR5A2 and pancreatic cancer risk. Gut (2013) 0.76
Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nat Commun (2016) 0.75