Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.

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Published in Cancer Discov on June 14, 2013

Authors

Mavee Witherspoon1, Qiuying Chen, Levy Kopelovich, Steven S Gross, Steven M Lipkin

Author Affiliations

1: 1Departments of Medicine, Genetic Medicine and Cell Biology, and 2Pharmacology, Weill Cornell College of Medicine, New York, New York; and 3Division of Chemoprevention, National Cancer Institute, Frederick, Maryland.

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