Published in Anal Chem on August 15, 2009
Human metabolic individuality in biomedical and pharmaceutical research. Nature (2011) 6.56
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab (2012) 3.64
alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One (2010) 2.94
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform (2010) 2.69
Reprogramming of the circadian clock by nutritional challenge. Cell (2013) 2.47
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun (2014) 2.39
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A (2012) 2.22
Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide. Mol Cell (2015) 2.18
Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol (2011) 2.04
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell (2016) 1.99
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS One (2012) 1.97
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest (2013) 1.89
Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus-mediated liver disease posttransplantation. Hepatology (2012) 1.82
Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis. Cancer Res (2012) 1.81
Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study. Kidney Int (2014) 1.80
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol (2012) 1.79
Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism (2010) 1.77
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery. J Matern Fetal Neonatal Med (2010) 1.77
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One (2011) 1.74
Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer Prev Res (Phila) (2012) 1.66
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation (2012) 1.60
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab (2014) 1.56
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome. Metabolomics (2013) 1.47
Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc Natl Acad Sci U S A (2015) 1.41
A practical approach to detect unique metabolic patterns for personalized medicine. Analyst (2010) 1.41
Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling. Nat Cell Biol (2017) 1.38
Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One (2016) 1.38
A sister group contrast using untargeted global metabolomic analysis delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus. Plant Cell (2011) 1.37
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun (2015) 1.36
Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. Am J Clin Nutr (2014) 1.35
Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PLoS One (2011) 1.35
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab (2014) 1.34
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res (2013) 1.31
Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage. Cell Rep (2015) 1.31
Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes. Gastroenterology (2013) 1.27
Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Res (2014) 1.26
Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis. Cancer Res (2015) 1.24
Human metabolic correlates of body mass index. Metabolomics (2014) 1.24
Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer. OMICS (2011) 1.23
Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol (2011) 1.20
Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep (2013) 1.19
Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome. Gut Microbes (2014) 1.19
Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ (2012) 1.19
Metabolic signatures of bacterial vaginosis. MBio (2015) 1.18
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J (2010) 1.18
Feeding healthy beagles medium-chain triglycerides, fish oil, and carnitine offsets age-related changes in serum fatty acids and carnitine metabolites. PLoS One (2012) 1.18
Target of rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis. Plant Cell (2012) 1.16
Urinary acylcarnitines are altered in human kidney cancer. Int J Cancer (2011) 1.14
Tobacco drought stress responses reveal new targets for Solanaceae crop improvement. BMC Genomics (2015) 1.11
Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer. Cancer Med (2014) 1.10
A Gradient of Glycolytic Activity Coordinates FGF and Wnt Signaling during Elongation of the Body Axis in Amniote Embryos. Dev Cell (2017) 1.10
Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors. BMC Infect Dis (2013) 1.10
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation. Toxicol Sci (2012) 1.09
Metabolic variation between japonica and indica rice cultivars as revealed by non-targeted metabolomics. Sci Rep (2014) 1.08
Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes (2012) 1.07
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes (2013) 1.06
Development of Ecom₅₀ and retention index models for nontargeted metabolomics: identification of 1,3-dicyclohexylurea in human serum by HPLC/mass spectrometry. J Chem Inf Model (2012) 1.06
The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res (2012) 1.05
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS One (2014) 1.05
Novel roles for the polyphenol oxidase enzyme in secondary metabolism and the regulation of cell death in walnut. Plant Physiol (2014) 1.04
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest (2014) 1.03
Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice. PLoS One (2012) 1.03
Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol (2014) 1.01
Metabolomics reveals differential levels of oral metabolites in HIV-infected patients: toward novel diagnostic targets. OMICS (2011) 1.01
Metabolomic profiling reveals biochemical pathways and biomarkers associated with pathogenesis in cystic fibrosis cells. J Biol Chem (2010) 1.00
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC Bioinformatics (2012) 0.99
Metabolomic profile of hepatitis C virus-infected hepatocytes. PLoS One (2011) 0.99
Plasma metabolomic profiles in different stages of CKD. Clin J Am Soc Nephrol (2012) 0.98
Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells. PLoS One (2015) 0.97
Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol Cancer Res (2013) 0.97
Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest (2010) 0.97
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med (2014) 0.97
Serum metabolomic profiling and incident CKD among African Americans. Clin J Am Soc Nephrol (2014) 0.96
HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster. PLoS Genet (2013) 0.96
Metabolic cycles in a circannual hibernator. Physiol Genomics (2011) 0.96
Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism. J Inherit Metab Dis (2015) 0.95
Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice. PLoS One (2014) 0.95
Genetic regulation of mouse liver metabolite levels. Mol Syst Biol (2014) 0.95
Genetic determinants influencing human serum metabolome among African Americans. PLoS Genet (2014) 0.95
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer Discov (2013) 0.95
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. PLoS One (2013) 0.94
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy (2012) 0.94
The heritability of metabolite concentrations in stored human red blood cells. Transfusion (2014) 0.94
Global metabolomic analysis of human saliva and plasma from healthy and diabetic subjects, with and without periodontal disease. PLoS One (2014) 0.94
Stress-induced cytokinin synthesis increases drought tolerance through the coordinated regulation of carbon and nitrogen assimilation in rice. Plant Physiol (2013) 0.94
Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach. PLoS One (2013) 0.93
Circadian rhythm reprogramming during lung inflammation. Nat Commun (2014) 0.92
Sources of variability in metabolite measurements from urinary samples. PLoS One (2014) 0.92
Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. J Biol Chem (2012) 0.92
Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults. PLoS One (2013) 0.92
Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int (2014) 0.91
Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease. Int J Obes (Lond) (2014) 0.91
Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants. PLoS One (2014) 0.91
Measurement of DNA concentration as a normalization strategy for metabolomic data from adherent cell lines. Anal Chem (2013) 0.91
Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats. PLoS One (2012) 0.91
Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding. FASEB J (2011) 0.91
Emerging infectious diseases in cetaceans worldwide and the possible role of environmental stressors. Dis Aquat Organ (2009) 1.73
Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus. Virus Res (2005) 1.66
A real time RT-PCR assay for the specific detection of Peste des petits ruminants virus. J Virol Methods (2010) 1.35
Development of one-step real-time RT-PCR assay for detection and quantitation of peste des petits ruminants virus. J Virol Methods (2008) 1.11
Successful reduction of massive postpartum haemorrhage by use of guidelines and staff education. BJOG (2004) 0.97
Reverse genetics for peste-des-petits-ruminants virus (PPRV): promoter and protein specificities. Virus Res (2007) 0.85
Real-time RT-PCR assays for the rapid and differential detection of dolphin and porpoise morbilliviruses. J Virol Methods (2008) 0.85
Sequence of the nucleocapsid gene and genome and antigenome promoters for an isolate of porpoise morbillivirus. Virus Res (2007) 0.81
Epidemiology, pathology, and genetic analysis of a canine distemper epidemic in Namibia. J Wildl Dis (2009) 0.80
Sequence analysis of the phosphoprotein gene of peste des petits ruminants (PPR) virus: editing of the gene transcript. Virus Res (2003) 0.78
Importance of the extracellular and cytoplasmic/transmembrane domains of the haemagglutinin protein of rinderpest virus for recovery of viable virus from cDNA copies. Virus Res (2005) 0.78
First metatarsophalangeal hemiarthroplasty for hallux rigidus. Int Orthop (2010) 0.75
Expression from baculovirus and serological reactivity of the nucleocapsid protein of dolphin morbillivirus. Vet Microbiol (2009) 0.75
Using nutrition to ward off side effects. Posit Aware (2004) 0.75
As goes Milwaukee's health, so goes Wisconsin's health. WMJ (2007) 0.75