Published in Adv Exp Med Biol on January 01, 2013
Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proc Natl Acad Sci U S A (2014) 0.90
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
A new class of cancer-associated PTEN mutations defined by membrane translocation defects. Oncogene (2014) 0.82
Tipping the balance from angiogenesis to fibrosis in CKD. Kidney Int Suppl (2011) (2014) 0.79
Engineering PTEN function: membrane association and activity. Methods (2014) 0.79
Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN. Sci Rep (2015) 0.76
Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Sci Rep (2016) 0.76
Defective phosphoinositide metabolism in autism. J Neurosci Res (2016) 0.76
Biophysical methods for the characterization of PTEN/lipid bilayer interactions. Methods (2015) 0.75
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36
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Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00
Lipid rafts as a membrane-organizing principle. Science (2010) 13.48
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Supported membranes: scientific and practical applications. Science (1996) 7.90
Pten dose dictates cancer progression in the prostate. PLoS Biol (2003) 7.62
The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
Supported phospholipid bilayers. Biophys J (1985) 6.18
Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06
Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22
Impaired Fas response and autoimmunity in Pten+/- mice. Science (1999) 4.25
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet (2005) 4.14
A biosensor that uses ion-channel switches. Nature (1997) 4.05
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell (1998) 3.90
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science (1999) 3.70
G-protein signaling through tubby proteins. Science (2001) 3.59
PTEN: life as a tumor suppressor. Exp Cell Res (2001) 3.41
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem (2001) 3.27
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell (1998) 3.21
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature (2011) 3.14
PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol (2012) 3.11
Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol (2004) 3.03
Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A (2003) 2.92
Polymer-supported membranes as models of the cell surface. Nature (2005) 2.91
Receptor activation alters inner surface potential during phagocytosis. Science (2006) 2.69
Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol (2002) 2.68
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60
Membrane protein sequestering by ionic protein-lipid interactions. Nature (2011) 2.40
PTEN: The down side of PI 3-kinase signalling. Cell Signal (2002) 2.34
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
PTEN mutation in a family with Cowden syndrome and autism. Am J Med Genet (2001) 2.14
Role of cholesterol in the formation and nature of lipid rafts in planar and spherical model membranes. Biophys J (2004) 2.08
Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 2.07
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev Cell (2005) 2.06
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science (2002) 2.05
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J (2009) 2.00
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol (2005) 2.00
Nuclear lipid signalling. Nat Rev Mol Cell Biol (2003) 2.00
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2003) 1.94
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion. J Cell Biol (2008) 1.89
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin. J Cell Biol (2007) 1.78
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem (2007) 1.75
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J Cell Sci (2009) 1.75
Phosphoinositides: lipid regulators of membrane proteins. J Physiol (2010) 1.72
Measuring distances in supported bilayers by fluorescence interference-contrast microscopy: polymer supports and SNARE proteins. Biophys J (2003) 1.71
Supported membranes on soft polymer cushions: fabrication, characterization and applications. Trends Biotechnol (2000) 1.63
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol (2002) 1.62
Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly. Autism Res (2010) 1.60
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene (2011) 1.59
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun (2012) 1.58
Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes. Biointerphases (2007) 1.54
Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly. Am J Med Genet A (2007) 1.52
A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis. Plant Cell (2002) 1.47
Target-specific PIP(2) signalling: how might it work? J Physiol (2007) 1.45
Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J (1987) 1.43
Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci U S A (2010) 1.40
Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation. J Cell Biol (2009) 1.38
A new lipid anchor for sparsely tethered bilayer lipid membranes. Langmuir (2009) 1.38
Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum. Trends Cell Biol (2009) 1.37
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol (2009) 1.36
Domain registration in raft-mimicking lipid mixtures studied using polymer-tethered lipid bilayers. Biophys J (2006) 1.36
Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity. Biophys J (2008) 1.36
Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. J Biol Chem (2003) 1.33
Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J Med Genet (1994) 1.33
HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid. J Mol Biol (2010) 1.33
Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol (2009) 1.31
Enzyme activity to augment the characterization of tethered bilayer membranes. J Phys Chem B (2006) 1.29
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes. Biochemistry (2008) 1.28
PTEN enters the nucleus by diffusion. J Cell Biochem (2005) 1.28
Structure of functional Staphylococcus aureus alpha-hemolysin channels in tethered bilayer lipid membranes. Biophys J (2009) 1.27
OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin. EMBO J (2011) 1.21
Families of phosphoinositide-specific phospholipase C: structure and function. Biochim Biophys Acta (1998) 1.21
Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat Cell Biol (2007) 1.20
Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur J Cell Biol (2006) 1.20
Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci Signal (2012) 1.15
Ionization properties of phosphatidylinositol polyphosphates in mixed model membranes. Biochemistry (2009) 1.13
Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS One (2012) 1.12
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol (2010) 1.11
Novel PTEN mutations in neurodevelopmental disorders and macrocephaly. Clin Genet (2008) 1.11
Redox enzymes in tethered membranes. J Am Chem Soc (2006) 1.09
Structural models of lipid surface monolayers from X-ray and neutron reflectivity measurements. Adv Colloid Interface Sci (2000) 1.08
A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol (2012) 1.06
Signaling mechanisms for chemotaxis. Dev Growth Differ (2011) 1.04
Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling. Sci Signal (2011) 1.02
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. Biochem J (1996) 1.00
Electrostatic interactions and binding orientation of HIV-1 matrix studied by neutron reflectivity. Biophys J (2010) 0.97
Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential. J Biol Chem (2011) 0.97
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2003) 1.94
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J (2009) 1.94
Leptin regulates AMPA receptor trafficking via PTEN inhibition. J Neurosci (2010) 1.91
AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences. Rev Sci Instrum (2006) 1.86
Regulation of the PTEN phosphatase. Gene (2006) 1.69
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med (2010) 1.55
Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes. Biointerphases (2007) 1.54
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci (2002) 1.43
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest (2011) 1.41
A new lipid anchor for sparsely tethered bilayer lipid membranes. Langmuir (2009) 1.38
Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity. Biophys J (2008) 1.36
Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochem (2009) 1.35
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Why is PTEN an important tumor suppressor? J Cell Biochem (2007) 1.31
Enzyme activity to augment the characterization of tethered bilayer membranes. J Phys Chem B (2006) 1.29
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes. Biochemistry (2008) 1.28
PTEN enters the nucleus by diffusion. J Cell Biochem (2005) 1.28
Structure of functional Staphylococcus aureus alpha-hemolysin channels in tethered bilayer lipid membranes. Biophys J (2009) 1.27
Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res (2010) 1.23
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors. Neuro Oncol (2008) 1.18
Size-dependent neurotoxicity of beta-amyloid oligomers. Arch Biochem Biophys (2010) 1.17
An ion-channel-containing model membrane: structural determination by magnetic contrast neutron reflectometry. Soft Matter (2009) 1.15
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol (2004) 1.14
Anomalous x-ray reflectivity characterization of ion distribution at biomimetic membranes. Phys Rev Lett (2003) 1.13
Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS One (2012) 1.12
Sorafenib exerts anti-glioma activity in vitro and in vivo. Neurosci Lett (2010) 1.12
PTEN regulation of neural development and CNS stem cells. J Cell Biochem (2003) 1.09
Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration. J Nanobiotechnology (2011) 1.08
In-plane homogeneity and lipid dynamics in tethered bilayer lipid membranes (tBLMs). Soft Matter (2010) 1.03
Glioblastoma multiforme therapy and mechanisms of resistance. Pharmaceuticals (Basel) (2013) 1.00
Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules. Langmuir (2013) 0.99
Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres. Cancer Lett (2010) 0.98
Electrostatic interactions and binding orientation of HIV-1 matrix studied by neutron reflectivity. Biophys J (2010) 0.97
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. Am J Pathol (2006) 0.97
Resolution of inflammation by N-arachidonoylglycine. J Cell Biochem (2011) 0.96
A unified nomenclature and amino acid numbering for human PTEN. Sci Signal (2014) 0.95
Stable insulating tethered bilayer lipid membranes. Biointerphases (2008) 0.94
Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma. Mol Cancer Ther (2010) 0.94
Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry (2002) 0.94
A mutant form of PTEN linked to autism. Protein Sci (2010) 0.93
Membrane association of the PTEN tumor suppressor: electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail. J Struct Biol (2012) 0.92
Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure. J Neurosurg (2005) 0.91
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res (2007) 0.90
Continuous distribution model for the investigation of complex molecular architectures near interfaces with scattering techniques. J Appl Phys (2011) 0.89
A screen for novel phosphoinositide 3-kinase effector proteins. Mol Cell Proteomics (2011) 0.88
Effect of hydrophobic surfactant protein SP-C on binary phospholipid monolayers. Molecular machinery at the air/water interface. Biophys Chem (2002) 0.88
Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol (2005) 0.87
Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering. J Biol Chem (2014) 0.86
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J Biol Chem (2012) 0.85
Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association. Biophys J (2013) 0.84
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. PLoS One (2013) 0.83
Headgroup organization and hydration of methylated phosphatidylethanolamines in Langmuir monolayers. Phys Chem Chem Phys (2005) 0.82
Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis (2004) 0.81
A method for clonal analysis of epidermal growth factor-responsive neural progenitors. J Neurosci Methods (2002) 0.81
Profiling of genes expressed by PTEN haploinsufficient neural precursor cells. Mol Cell Neurosci (2003) 0.81
Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One (2012) 0.80
Interaction of the neurotransmitter, neuropeptide Y, with phospholipid membranes: film balance and fluorescence microscopy studies. J Phys Chem B (2006) 0.80
Interaction of the neurotransmitter, neuropeptide Y, with phospholipid membranes: infrared spectroscopic characterization at the air/water interface. J Phys Chem B (2006) 0.79
Three-dimensional bioprinting of complex cell laden alginate hydrogel structures. Biofabrication (2015) 0.78
Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. J Neurosci Res (2003) 0.78
The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease. Subcell Biochem (2012) 0.77
Neutron reflectometry of supported hybrid bilayers with inserted peptide. Soft Matter (2010) 0.76
The PTEN Tumor Suppressor Forms Homodimers in Solution. Structure (2015) 0.75
Differentiation prevents assessment of neural stem cell pluripotency after blastocyst injection. Stem Cells (2004) 0.75