Published in Cell on May 31, 2002
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol (2005) 2.99
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Nat Neurosci (2006) 2.42
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol (2006) 2.13
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol (2005) 2.05
Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol (2003) 2.05
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
Directional sensing in eukaryotic chemotaxis: a balanced inactivation model. Proc Natl Acad Sci U S A (2006) 1.98
Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci U S A (2012) 1.92
Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys J (2004) 1.91
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol (2007) 1.80
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci (2009) 1.80
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin. J Clin Invest (2008) 1.78
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
Biased random walk by stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection. Biophys J (2007) 1.74
Calpain regulates neutrophil chemotaxis. Proc Natl Acad Sci U S A (2003) 1.73
Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nat Rev Mol Cell Biol (2010) 1.73
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol (2006) 1.73
Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol (2004) 1.72
Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Mol Biol Cell (2003) 1.70
Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J Cell Biol (2008) 1.69
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood (2007) 1.65
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol (2010) 1.64
Chemotaxis, chemokine receptors and human disease. Cytokine (2008) 1.63
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Chemotaxis: signalling modules join hands at front and tail. EMBO Rep (2004) 1.61
Spatiotemporal regulation of Ras activity provides directional sensing. Curr Biol (2008) 1.60
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A (2010) 1.53
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
PI 3-kinases and PTEN: how opposites chemoattract. Cell (2002) 1.46
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Proc Natl Acad Sci U S A (2010) 1.45
Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A (2007) 1.40
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39
Ordered patterns of cell shape and orientational correlation during spontaneous cell migration. PLoS One (2008) 1.38
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell (2006) 1.38
Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol (2007) 1.35
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol (2013) 1.34
Ion channels in microbes. Physiol Rev (2008) 1.33
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci (2008) 1.32
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity. Biophys J (2005) 1.28
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol (2009) 1.26
Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One (2010) 1.25
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis. Mol Biol Cell (2005) 1.25
Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J Cell Biol (2007) 1.25
Cellular responses to extracellular guidance cues. EMBO J (2010) 1.25
Modeling cellular deformations using the level set formalism. BMC Syst Biol (2008) 1.25
Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol (2011) 1.24
PTEN: Multiple Functions in Human Malignant Tumors. Front Oncol (2015) 1.24
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility. PLoS Comput Biol (2012) 1.22
Distinguishing modes of eukaryotic gradient sensing. Biophys J (2005) 1.22
Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem (2013) 1.22
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood (2009) 1.19
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
Golgi polarization in a strong electric field. J Cell Sci (2005) 1.16
Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A (2012) 1.15
Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem (2010) 1.14
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. Biophys J (2004) 1.13
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J Cell Biol (2005) 1.13
Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Mol Biol Cell (2007) 1.12
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Dev Biol (2007) 1.12
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell (2008) 1.11
Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxis. Sci Signal (2012) 1.10
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10
A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell (2011) 1.10
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J Exp Med (2013) 1.09
A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev (2004) 1.08
Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis. Curr Biol (2013) 1.08
Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling. J Cell Biol (2007) 1.08
Bleb-driven chemotaxis of Dictyostelium cells. J Cell Biol (2014) 1.06
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell (2008) 1.06
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
Temporal and spatial regulation of chemotaxis. Dev Cell (2002) 2.35
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev Cell (2005) 2.06
Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol (2006) 1.51
Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Curr Opin Genet Dev (2006) 1.43
Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle (2006) 1.18
Local excitation, global inhibition mechanism for gradient sensing: an interactive applet. Sci STKE (2004) 1.08
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife (2013) 1.02
Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol Biol Cell (2010) 1.00
Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility. J Cell Sci (2005) 0.98
Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods Mol Biol (2009) 0.95
Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic (2006) 0.95
RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryot Cell (2006) 0.90
From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Curr Opin Cell Biol (2004) 0.84
Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene. Dev Biol (2002) 0.84
Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer. Methods (2002) 0.81
Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine (2011) 0.79
Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle (2011) 0.75