Published in J Cell Biol on March 22, 2010
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. J Cell Biol (2010) 3.25
Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell (2012) 2.87
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45
Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol (2010) 2.36
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol (2013) 2.14
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. J Cell Biol (2012) 2.12
Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy. Nat Methods (2012) 2.00
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol (2014) 1.94
Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc Natl Acad Sci U S A (2012) 1.89
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells. Mol Biol Cell (2012) 1.82
Spatiotemporal constraints on the force-dependent growth of focal adhesions. Biophys J (2011) 1.69
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci (2011) 1.57
Cell-matrix adhesions in 3D. Matrix Biol (2011) 1.54
Materials as stem cell regulators. Nat Mater (2014) 1.53
Strength in the periphery: growth cone biomechanics and substrate rigidity response in peripheral and central nervous system neurons. Biophys J (2012) 1.48
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Cell (2016) 1.46
Vinculin, an adapter protein in control of cell adhesion signalling. Eur J Cell Biol (2010) 1.44
Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol (2011) 1.36
Distinct signaling mechanisms regulate migration in unconfined versus confined spaces. J Cell Biol (2013) 1.34
The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties. J Biol Chem (2011) 1.32
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci (2012) 1.26
From mechanical force to RhoA activation. Biochemistry (2012) 1.23
Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. J Cell Sci (2012) 1.23
Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Nat Cell Biol (2015) 1.23
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell (2011) 1.22
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem (2013) 1.19
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol (2014) 1.19
S100A4 regulates macrophage chemotaxis. Mol Biol Cell (2010) 1.19
Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophys J (2011) 1.19
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med (2014) 1.17
Determinants of maximal force transmission in a motor-clutch model of cell traction in a compliant microenvironment. Biophys J (2013) 1.17
A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling. Sci Signal (2014) 1.15
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A (2012) 1.14
The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res (2012) 1.10
Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell (2013) 1.10
Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations. Nat Commun (2013) 1.08
Functions of nonmuscle myosin II in assembly of the cellular contractile system. PLoS One (2012) 1.08
Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol (2011) 1.07
A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis. Dev Dyn (2011) 1.05
mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow-derived mesenchymal stem cells. J Bone Miner Res (2014) 1.04
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. J Cell Biol (2015) 1.04
Actomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring. Nat Commun (2014) 1.03
Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02
Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma. PLoS One (2010) 1.02
The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites. J Biol Chem (2012) 1.01
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
Actin stress fibre subtypes in mesenchymal-migrating cells. Open Biol (2013) 0.99
Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments. Nat Mater (2015) 0.99
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nat Rev Neurosci (2013) 0.97
Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One (2012) 0.97
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci (2012) 0.96
p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res (2011) 0.96
PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Curr Biol (2012) 0.96
Shroom2 regulates contractility to control endothelial morphogenesis. Mol Biol Cell (2011) 0.95
Netrin-1 attracts axons through FAK-dependent mechanotransduction. J Neurosci (2012) 0.94
Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover. Proc Natl Acad Sci U S A (2013) 0.93
Activation of beta 1 but not beta 3 integrin increases cell traction forces. FEBS Lett (2013) 0.92
Differential effect of actomyosin relaxation on the dynamic properties of focal adhesion proteins. PLoS One (2013) 0.91
Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells. Biophys J (2015) 0.91
Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr (2012) 0.90
Region-specific epithelial cell dynamics during branching morphogenesis. Dev Dyn (2013) 0.90
Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. PLoS One (2014) 0.89
Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions. Protoplasma (2012) 0.88
Mechanosensitive components of integrin adhesions: Role of vinculin. Exp Cell Res (2015) 0.87
S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. J Biol Chem (2012) 0.87
Contractile equilibration of single cells to step changes in extracellular stiffness. Biophys J (2012) 0.87
FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep (2014) 0.87
Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly. Proc Natl Acad Sci U S A (2015) 0.87
Non-channel mechanosensors working at focal adhesion-stress fiber complex. Pflugers Arch (2014) 0.86
Regulation of tissue fibrosis by the biomechanical environment. Biomed Res Int (2013) 0.86
Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. Eur J Cell Biol (2011) 0.86
The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin. Mol Biol Cell (2016) 0.86
The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration. Front Physiol (2013) 0.85
Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography. Am J Physiol Cell Physiol (2013) 0.85
The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction. Soft Matter (2013) 0.85
Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells. Mol Cell Biol (2014) 0.85
Substrate topography determines neuronal polarization and growth in vitro. PLoS One (2013) 0.84
Actomyosin bundles serve as a tension sensor and a platform for ERK activation. EMBO Rep (2014) 0.84
FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination. J Neurosci (2014) 0.83
α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation. Exp Cell Res (2013) 0.83
A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction. Can J Physiol Pharmacol (2014) 0.83
To pull or be pulled: parsing the multiple modes of mechanotransduction. Curr Opin Cell Biol (2013) 0.82
Direct observation of α-actinin tension and recruitment at focal adhesions during contact growth. Exp Cell Res (2014) 0.82
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS One (2012) 0.82
Plasticity in the macromolecular-scale causal networks of cell migration. PLoS One (2014) 0.82
Microtubule-dependent modulation of adhesion complex composition. PLoS One (2014) 0.82
Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Sci Rep (2016) 0.82
A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. J Cell Sci (2013) 0.82
Confocal reference free traction force microscopy. Nat Commun (2016) 0.82
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46
Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol (1997) 11.36
Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol (2006) 11.29
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol (1996) 11.04
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Stretching single talin rod molecules activates vinculin binding. Science (2009) 8.11
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol (1992) 7.97
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell (2006) 7.35
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell (1987) 6.91
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
The relationship between force and focal complex development. J Cell Biol (2002) 6.26
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol (2008) 5.87
Differential transmission of actin motion within focal adhesions. Science (2007) 5.36
Mechanically activated integrin switch controls alpha5beta1 function. Science (2009) 4.94
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85
Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nat Cell Biol (2007) 4.26
Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. J Cell Biol (2001) 3.99
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol (1995) 3.85
Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophys J (2006) 3.83
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature (2003) 3.70
Spatial mapping of integrin interactions and dynamics during cell migration by image correlation microscopy. J Cell Sci (2004) 3.70
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell (2008) 3.54
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol (1999) 3.34
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol (1996) 3.21
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. J Cell Biol (2006) 3.15
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res (2008) 3.11
Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol (2004) 3.03
Measurement of dynamic protein binding to chromatin in vivo, using photobleaching microscopy. Methods Enzymol (2004) 3.02
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Paxillin interactions. J Cell Sci (2000) 2.67
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol (1996) 2.63
Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem (1995) 2.44
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol (2000) 2.13
Rapid dynamics of the microtubule binding of ensconsin in vivo. J Cell Sci (2001) 2.10
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci (2006) 1.83
Coincidence of actin filaments and talin is required to activate vinculin. J Biol Chem (2006) 1.81
Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin. J Cell Sci (1999) 1.72
A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. Mol Biol Cell (2003) 1.72
Vinculin acts as a sensor in lipid regulation of adhesion-site turnover. J Cell Sci (2005) 1.66
Identification of a talin binding site in the cytoskeletal protein vinculin. J Cell Biol (1989) 1.60
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading. Cell Motil Cytoskeleton (2004) 1.59
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane. Am J Physiol Cell Physiol (2003) 1.56
Characterization of an actin-binding site within the talin FERM domain. J Mol Biol (2004) 1.55
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS One (2009) 1.50
Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells. Mol Biol Cell (2007) 1.33
Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31
Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion. Mol Biol Cell (2009) 1.25
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol (2005) 1.25
GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Cell Signal (2007) 1.23
Becoming stable and strong: the interplay between vinculin exchange dynamics and adhesion strength during adhesion site maturation. Cell Motil Cytoskeleton (2009) 1.14
A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophys Chem (2005) 1.01
Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochemistry (2007) 0.88
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Nanoscale architecture of integrin-based cell adhesions. Nature (2010) 5.88
Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure. Proc Natl Acad Sci U S A (2009) 5.31
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science (2004) 3.93
High resolution traction force microscopy based on experimental and computational advances. Biophys J (2007) 3.89
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J Cell Biol (2008) 3.44
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell (2012) 2.87
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy. Nat Biotechnol (2013) 1.92
FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol (2012) 1.87
Local cortical tension by myosin II guides 3D endothelial cell branching. Curr Biol (2009) 1.85
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol (2005) 1.70
Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem (2003) 1.67
Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol (2013) 1.63
Microscopy in 3D: a biologist's toolbox. Trends Cell Biol (2011) 1.62
A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell (2010) 1.62
The focal adhesion kinase--a regulator of cell migration and invasion. IUBMB Life (2002) 1.55
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J (2002) 1.55
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55
Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res (2006) 1.55
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res (2009) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. J Biol Chem (2003) 1.43
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J Biol Chem (2002) 1.31
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci (2003) 1.28
Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion. Mol Biol Cell (2009) 1.25
Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis. J Cell Biol (2011) 1.24
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis (2012) 1.20
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src. J Biol Chem (2003) 1.15
Guiding cell migration by tugging. Curr Opin Cell Biol (2013) 1.14
Protrusion and actin assembly are coupled to the organization of lamellar contractile structures. Exp Cell Res (2010) 1.12
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol (2014) 1.07
Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization. PLoS One (2011) 1.07
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol (2012) 1.02
Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells. PLoS One (2012) 1.01
Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. J Biol Chem (2011) 1.01
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. PLoS One (2012) 1.00
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups. Biophys J (2004) 1.00
Directed cell migration in multi-cue environments. Integr Biol (Camb) (2013) 0.99
Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Nat Protoc (2012) 0.99
FAK nuclear export signal sequences. FEBS Lett (2008) 0.98
Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One (2012) 0.97
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci (2012) 0.96
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol (2007) 0.96
Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. Proc Natl Acad Sci U S A (2011) 0.96
p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res (2011) 0.96
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. J Cell Biol (2011) 0.95
Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog (2009) 0.94
Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover. Proc Natl Acad Sci U S A (2013) 0.93
The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J Biol Chem (2004) 0.93
Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors. Annu Rev Biophys (2015) 0.92
On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling. J Theor Biol (2004) 0.90
Advances in light-based imaging of three-dimensional cellular ultrastructure. Curr Opin Cell Biol (2011) 0.90
Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr (2012) 0.90
Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex. Mol Cell Biol (2013) 0.89
Isolation of focal adhesion proteins for biochemical and proteomic analysis. Methods Mol Biol (2012) 0.89
Incoherent structured illumination improves optical sectioning and contrast in multiphoton super-resolution microscopy. Opt Express (2015) 0.87
Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins. PLoS One (2012) 0.85
A PAK-activated linker for EGFR and FAK. Dev Cell (2010) 0.85
Event ordering in live-cell imaging determined from temporal cross-correlation asymmetry. Biophys J (2010) 0.84
Epitaxially grown collagen fibrils reveal diversity in contact guidance behavior among cancer cells. Langmuir (2014) 0.83
A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. J Cell Sci (2013) 0.82
Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol (2006) 0.82
How we discovered fluorescent speckle microscopy. Mol Biol Cell (2011) 0.81
Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation. BMC Biophys (2012) 0.78
Localization-based super-resolution imaging of cellular structures. Methods Mol Biol (2013) 0.77
Establishment of cell lines from mouse embryos with early embryonic lethality. Cell Commun Adhes (2008) 0.77
Modeling and measuring signal relay in noisy directed migration of cell groups. PLoS Comput Biol (2013) 0.76
Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods Mol Biol (2014) 0.76
pHocal adhesion kinase regulation is on a FERM foundation. J Cell Biol (2013) 0.75
Mixed-surface, lipid-tethered quantum dots for targeting cells and tissues. Colloids Surf B Biointerfaces (2012) 0.75
Collagen attachment to the substrate controls cell clustering through migration. Phys Biol (2014) 0.75