PubRank

Bernhard Ryffel

Author PubWeight™ 190.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 2009 6.73
2 The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013 4.60
3 Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med 2006 4.38
4 NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest 2013 2.96
5 Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 2010 2.89
6 IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 2007 2.88
7 Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 2008 2.83
8 IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 2007 2.73
9 Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med 2012 2.71
10 Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. J Clin Invest 2004 2.65
11 Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proc Natl Acad Sci U S A 2007 2.64
12 Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 2007 2.58
13 Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009 2.45
14 Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum 2012 2.43
15 Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 2005 2.35
16 Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection. Am J Pathol 2004 2.27
17 Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 2002 2.17
18 Cutting edge: Priming of NK cells by IL-18. J Immunol 2008 2.08
19 Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut 2012 1.97
20 Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect 2004 1.94
21 NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood 2004 1.88
22 Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 2010 1.84
23 NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. Arthritis Rheum 2012 1.83
24 Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity 2012 1.82
25 Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J Immunol 2004 1.81
26 Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun 2004 1.77
27 VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases. Proc Natl Acad Sci U S A 2007 1.68
28 Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol 2005 1.59
29 Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J Clin Invest 2014 1.58
30 IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol 2011 1.57
31 iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice. PLoS Pathog 2009 1.53
32 Reactivation of latent tuberculosis infection in TNF-deficient mice. J Immunol 2003 1.52
33 Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A 2005 1.50
34 Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol 2010 1.44
35 TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol 2010 1.43
36 Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol 2007 1.41
37 Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. PLoS Pathog 2010 1.39
38 Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol 2007 1.38
39 Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med 2011 1.38
40 Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J Immunol 2003 1.36
41 Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther 2014 1.35
42 Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages. J Biol Chem 2012 1.35
43 IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One 2011 1.32
44 Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J Mol Cell Biol 2011 1.32
45 IL-17 receptor signaling is required to control polymicrobial sepsis. J Immunol 2009 1.31
46 Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol 2011 1.25
47 The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol 2005 1.23
48 All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One 2011 1.20
49 IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol 2009 1.17
50 Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int J Exp Pathol 2007 1.15
51 Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs. Clin Exp Metastasis 2009 1.15
52 Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan. J Biol Chem 2007 1.15
53 Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro. J Interferon Cytokine Res 2006 1.14
54 Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells. J Immunol 2010 1.14
55 IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol 2013 1.14
56 Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep 2013 1.10
57 Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. Am J Respir Crit Care Med 2007 1.09
58 Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice. J Infect Dis 2010 1.09
59 IFN-γ production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner. PLoS Negl Trop Dis 2011 1.06
60 Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice. Infect Immun 2004 1.06
61 TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J Leukoc Biol 2006 1.05
62 Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum 2013 1.05
63 Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells. Immunol Lett 2007 1.04
64 In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice. PLoS Pathog 2012 1.04
65 IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine 2005 1.04
66 Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome. J Mol Cell Biol 2012 1.04
67 Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One 2012 1.04
68 Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice. Infect Immun 2012 1.02
69 Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway. Med Microbiol Immunol 2009 1.02
70 Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol 2005 1.02
71 Tumor necrosis factor is critical to control tuberculosis infection. Microbes Infect 2007 1.02
72 Arthropod-derived histamine-binding protein prevents murine allergic asthma. J Immunol 2004 1.01
73 Membrane TNF confers protection to acute mycobacterial infection. Respir Res 2005 1.00
74 MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. J Clin Invest 2013 1.00
75 TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii. J Immunol 2010 0.99
76 Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology. Microbes Infect 2007 0.98
77 The development and function of follicular helper T cells in immune responses. Cell Mol Immunol 2012 0.98
78 Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin. Eur J Immunol 2009 0.98
79 Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli. Shock 2007 0.98
80 Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol 2011 0.98
81 SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. Cancer Res 2013 0.97
82 Endogenous leukemia inhibitory factor attenuates endotoxin response. Lab Invest 2005 0.97
83 Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med 2008 0.97
84 The microtubule regulator stathmin is an endogenous protein agonist for TLR3. J Immunol 2010 0.97
85 Membrane tumor necrosis factor confers partial protection to Listeria infection. Am J Pathol 2005 0.97
86 CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection. J Infect Dis 2008 0.96
87 Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. PLoS Pathog 2011 0.96
88 TNF in host resistance to tuberculosis infection. Curr Dir Autoimmun 2010 0.95
89 Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis. J Infect Dis 2009 0.95
90 Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia. J Immunol 2009 0.94
91 Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. Exp Hematol 2007 0.94
92 Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice. PLoS One 2010 0.94
93 Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury. PLoS One 2013 0.94
94 IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection. Eur J Immunol 2013 0.93
95 Pseudomonas aeruginosa type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome. Am J Respir Crit Care Med 2014 0.93
96 Tumor necrosis factor is not associated with intestinal ischemia/reperfusion-induced lung inflammation. Shock 2010 0.92
97 Roles of soluble and membrane TNF and related ligands in mycobacterial infections: effects of selective and non-selective TNF inhibitors during infection. Adv Exp Med Biol 2011 0.92
98 Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation. Blood 2008 0.92
99 Dengue virus infection: current concepts in immune mechanisms and lessons from murine models. Immunology 2014 0.92
100 A detrimental role for invariant natural killer T cells in the pathogenesis of experimental dengue virus infection. Am J Pathol 2011 0.91
101 Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J Immunol 2009 0.91
102 GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands. PLoS One 2012 0.91
103 Enhanced immune response in Mycobacterium bovis bacille calmette guerin (BCG)-infected IL-10-deficient mice. Clin Chem Lab Med 2002 0.90
104 Oral artesunate prevents Plasmodium berghei Anka infection in mice. Parasitol Int 2003 0.90
105 Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol 2010 0.90
106 Mycobacterial phosphatidylinositol mannosides negatively regulate host Toll-like receptor 4, MyD88-dependent proinflammatory cytokines, and TRIF-dependent co-stimulatory molecule expression. J Biol Chem 2009 0.90
107 Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. PLoS One 2012 0.90
108 Protein kinase C-theta is required for development of experimental cerebral malaria. Am J Pathol 2010 0.89
109 IL-12Rβ2 is essential for the development of experimental cerebral malaria. J Immunol 2012 0.89
110 RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury. J Mol Cell Biol 2013 0.89
111 Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice. Lab Invest 2004 0.89
112 Reactivation of latent tuberculosis by an inhibitor of inducible nitric oxide synthase in an aerosol murine model. Immunology 2002 0.88
113 Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. Lab Invest 2006 0.88
114 Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One 2008 0.88
115 Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci 2010 0.87
116 CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. J Leukoc Biol 2013 0.87
117 Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol 2013 0.87
118 Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology 2008 0.86
119 TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection. Microbes Infect 2009 0.86
120 Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells. J Mol Cell Biol 2013 0.86
121 Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis. J Immunol 2014 0.86
122 Reactivation of tuberculosis by tumor necrosis factor neutralization. Eur Cytokine Netw 2007 0.85
123 Limited role for lymphotoxin α in the host immune response to Mycobacterium tuberculosis. J Immunol 2010 0.85
124 The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. PLoS One 2013 0.84
125 IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation. J Pathol 2015 0.84
126 Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest 2014 0.84
127 Induced CD4+ forkhead box protein-positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1. J Allergy Clin Immunol 2012 0.84
128 Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain. Pain 2015 0.83
129 Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem 2013 0.83
130 Remote control of intestinal tumorigenesis by innate immunity. Cancer Res 2010 0.83
131 MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection. J Neuroinflammation 2013 0.82
132 Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection. Biochim Biophys Acta 2013 0.81
133 Synthetic triacylated lipid A derivative activates antigen presenting cells via the TLR4 pathway and promotes antigen-specific responses in vivo. Immunobiology 2006 0.79
134 Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells. J Leukoc Biol 2013 0.79
135 Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics. Am J Respir Cell Mol Biol 2011 0.79
136 Novel bacterial delivery system with attenuated Salmonella typhimurium carrying plasmid encoding Mtb antigen 85A for mucosal immunization: establishment of proof of principle in TB mouse model. Ann N Y Acad Sci 2005 0.79
137 Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol 2013 0.78
138 Control of allergic reactions in mice by an active anti-murine IL-4 immunization. Vaccine 2007 0.77
139 Thymic Stromal Lymphopoietin Enhances Th2/Th22 and Reduces IL-17A in Protease-Allergen-Induced Airways Inflammation. ISRN Allergy 2013 0.77
140 Adjuvant activity on murine and human macrophages. Methods Mol Biol 2010 0.77
141 Neurons are host cells for Mycobacterium tuberculosis. Infect Immun 2014 0.77
142 Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model. J Immunol 2013 0.77
143 Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection. J Infect Dis 2008 0.77
144 Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection. Infect Immun 2005 0.77
145 Anisakis pegreffii-induced airway hyperresponsiveness is mediated by gamma interferon in the absence of interleukin-4 receptor alpha responsiveness. Infect Immun 2010 0.77
146 Toll like receptor - potential drug targets in infectious disease. Infect Disord Drug Targets 2008 0.76
147 Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol 2015 0.76
148 Hepatic steatosis in the absence of tumor necrosis factor in mice. Cytokine 2006 0.76
149 Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation. J Allergy (Cairo) 2012 0.75
150 Antibody-independent thrombocytopenia in lactate dehydrogenase-elevating virus-infected mice. J Virol 2012 0.75
151 [Fatal tuberculosis despite adaptive immune response in the absence of MyD88]. Med Sci (Paris) 2005 0.75
152 The launch of the American Journal of Clinical and Experimental Immunology. Am J Clin Exp Immunol 2012 0.75
153 Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-alpha/lymphotoxin-alpha double-deficient mice. Immunol Lett 2005 0.75
154 Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: synthesis and anti-inflammatory properties. ChemMedChem 2011 0.75
155 American Journal of Clinical and Experimental Immunology: Editorial Board (2012) e-Century Publishing Corporation. Am J Clin Exp Immunol 2012 0.75
156 Arthropod-derived protein EV131 inhibits histamine action and allergic asthma. Ann N Y Acad Sci 2005 0.75