Evolving pharmacotherapies for the treatment of metastatic melanoma.

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Published in Clin Med Insights Oncol on June 20, 2013

Authors

April K S Salama1

Author Affiliations

1: Division of Medical Oncology, Duke University Medical Center, Durham NC, USA.

Associated clinical trials:

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma | NCT01584648

Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma (COMBI-v) | NCT01597908

Tremelimumab and CP-870,893 in Patients With Metastatic Melanoma | NCT01103635

Phase 3 Trial in Subjects With Metastatic Melanoma Comparing 3 mg/kg Ipilimumab Versus 10 mg/kg Ipilimumab | NCT01515189

Phase II Safety Study of Vemurafenib Followed by Ipilimumab in Subjects With V600 BRAF Mutated Advanced Melanoma | NCT01673854

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Thin malignant melanomas with regression and metastases. Arch Dermatol (1987) 1.16

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The role of the CD40 pathway in the pathogenesis and treatment of cancer. Curr Opin Pharmacol (2004) 1.01

Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers. Mol Carcinog (2005) 0.84

The significance of inflammation and regression in melanoma. Virchows Arch A Pathol Anat Histopathol (1992) 0.80

Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature. Melanoma Res (2010) 0.75