Improved survival with MEK inhibition in BRAF-mutated melanoma.

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Published in N Engl J Med on June 04, 2012

Authors

Keith T Flaherty1, Caroline Robert, Peter Hersey, Paul Nathan, Claus Garbe, Mohammed Milhem, Lev V Demidov, Jessica C Hassel, Piotr Rutkowski, Peter Mohr, Reinhard Dummer, Uwe Trefzer, James M G Larkin, Jochen Utikal, Brigitte Dreno, Marta Nyakas, Mark R Middleton, Jürgen C Becker, Michelle Casey, Laurie J Sherman, Frank S Wu, Daniele Ouellet, Anne-Marie Martin, Kiran Patel, Dirk Schadendorf, METRIC Study Group

Author Affiliations

1: Massachusetts General Hospital Cancer Center, Boston, USA. kflaherty@partners.org

Associated clinical trials:

GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma | NCT01245062

Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases | NCT02036086

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