Published in Nature on July 17, 2013
Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell (2013) 1.83
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (2014) 1.81
Extra-helical binding site of a glucagon receptor antagonist. Nature (2016) 1.65
Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature (2017) 1.55
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nat Rev Drug Discov (2014) 1.51
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature (2014) 1.48
Recent developments in biased agonism. Curr Opin Cell Biol (2013) 1.44
Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. PLoS One (2016) 1.39
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev (2015) 1.29
Insights into the structure of class B GPCRs. Trends Pharmacol Sci (2013) 1.25
Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends Pharmacol Sci (2014) 1.19
Conformational states of the full-length glucagon receptor. Nat Commun (2015) 1.04
Novel Allosteric Modulators of G Protein-coupled Receptors. J Biol Chem (2015) 1.02
From G Protein-coupled Receptor Structure Resolution to Rational Drug Design. J Biol Chem (2015) 0.99
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol (2015) 0.98
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature (2017) 0.97
Structure of the full-length glucagon class B G-protein-coupled receptor. Nature (2017) 0.96
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature (2017) 0.93
In silico analysis of the conservation of human toxicity and endocrine disruption targets in aquatic species. Environ Sci Technol (2014) 0.90
Identifying ligands at orphan GPCRs: current status using structure-based approaches. Br J Pharmacol (2016) 0.90
MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines. Acta Crystallogr D Biol Crystallogr (2015) 0.89
The recombinant expression systems for structure determination of eukaryotic membrane proteins. Protein Cell (2014) 0.89
Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors. J Chem Theory Comput (2014) 0.88
Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain. J Biol Chem (2015) 0.87
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism. Cell (2016) 0.87
Structure of Class B GPCRs: new horizons for drug discovery. Br J Pharmacol (2014) 0.86
Do plants contain g protein-coupled receptors? Plant Physiol (2013) 0.86
Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochim Biophys Acta (2013) 0.86
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Mol Pharmacol (2015) 0.85
Proton transfer-mediated GPCR activation. Protein Cell (2014) 0.85
Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology. Br J Pharmacol (2014) 0.85
Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R). J Biol Chem (2016) 0.85
A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources. J Synchrotron Radiat (2015) 0.84
Discovery of GPCR ligands for probing signal transduction pathways. Front Pharmacol (2014) 0.84
The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Biosci Rep (2015) 0.84
Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications. PLoS Comput Biol (2016) 0.83
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev (2015) 0.83
Structural Studies of G Protein-Coupled Receptors. Mol Cells (2015) 0.82
Structural conservation among the rhodopsin-like and other G protein-coupled receptors. Sci Rep (2015) 0.82
Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1. Sci Rep (2015) 0.82
Expression and functional characterization of membrane-integrated mammalian corticotropin releasing factor receptors 1 and 2 in Escherichia coli. PLoS One (2014) 0.81
Sequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysis. PLoS One (2015) 0.81
Stabilization of G protein-coupled receptors by point mutations. Front Pharmacol (2015) 0.81
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors. J Biol Chem (2016) 0.81
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles. J Biol Chem (2016) 0.81
Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. PLoS One (2014) 0.80
A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism. J Bone Miner Res (2015) 0.80
Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol (2015) 0.80
Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs. Eur J Pharmacol (2015) 0.80
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem (2016) 0.80
Conformational thermostabilisation of corticotropin releasing factor receptor 1. Sci Rep (2015) 0.80
Large-scale production and protein engineering of G protein-coupled receptors for structural studies. Front Pharmacol (2015) 0.79
How Can Mutations Thermostabilize G-Protein-Coupled Receptors? Trends Pharmacol Sci (2015) 0.79
Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors. Front Pharmacol (2015) 0.78
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacol Rev (2016) 0.78
Post-expression strategies for structural investigations of membrane proteins. Curr Opin Struct Biol (2015) 0.78
ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks. Nucleic Acids Res (2015) 0.78
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors. J Biol Chem (2016) 0.78
Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family. AAPS J (2015) 0.78
G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs. Front Aging Neurosci (2016) 0.78
Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism. J Biol Chem (2014) 0.78
A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies. Nat Protoc (2016) 0.77
Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain. PLoS One (2014) 0.77
Opioid receptors: Structural and mechanistic insights into pharmacology and signaling. Eur J Pharmacol (2015) 0.77
Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae. Biochemistry (2015) 0.77
Structural approaches to understanding retinal proteins needed for vision. Curr Opin Cell Biol (2013) 0.76
Structural characterization of triple transmembrane domain containing fragments of a yeast G protein-coupled receptor in an organic : aqueous environment by solution-state NMR spectroscopy. J Pept Sci (2015) 0.76
Don't stress about CRF: assessing the translational failures of CRF1antagonists. Psychopharmacology (Berl) (2017) 0.76
Structural biology: meet the B family. Nature (2013) 0.76
GRK5 intronic (CA)n polymorphisms associated with type 2 diabetes in Chinese Hainan Island. PLoS One (2014) 0.76
Drug discovery: Structure-led design. Nature (2013) 0.76
Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. Elife (2017) 0.76
Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions. J Comput Aided Mol Des (2016) 0.75
A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs. Methods Enzymol (2015) 0.75
Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis. Protein Cell (2014) 0.75
G protein-coupled receptors: two landmark class B GPCR structures unveiled. Nat Rev Drug Discov (2013) 0.75
Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor. J Biol Chem (2016) 0.75
Allosteric communication pipelines in G-protein-coupled receptors. Curr Opin Pharmacol (2016) 0.75
The MCH(1) receptor, an anti-obesity target, is allosterically inhibited by 8-methylquinoline derivatives possessing subnanomolar binding and long residence times. Br J Pharmacol (2014) 0.75
The Diamond Light Source and the challenges ahead for structural biology: some informal remarks. Philos Trans A Math Phys Eng Sci (2015) 0.75
Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor. Sci Rep (2016) 0.75
An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain. Cell Discov (2016) 0.75
Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor. PLoS One (2017) 0.75
Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structure. Acta Pharmacol Sin (2015) 0.75
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon. PLoS One (2016) 0.75
Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography. J Biol Chem (2016) 0.75
A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution. Sci Rep (2016) 0.75
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochem Pharmacol (2016) 0.75
Micro-scale and rapid expression screening of highly expressed and/or stable membrane protein variants in Saccharomyces cerevisiae. Protein Sci (2016) 0.75
Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochem Pharmacol (2016) 0.75
Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. Nat Commun (2016) 0.75
Synthetic Peptides as Protein Mimics. Front Bioeng Biotechnol (2016) 0.75
Editorial. Themed issue of the British Journal of Pharmacology. Br J Pharmacol (2014) 0.75
G protein-coupled receptors in cardiac biology: old and new receptors. Biophys Rev (2015) 0.75
Topography prediction of helical transmembrane proteins by a new modification of the sliding window method. Biomed Res Int (2014) 0.75
Arginine 199 and leucine 208 have key roles in the control of adenosine A2A receptor signalling function. PLoS One (2014) 0.75
Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges. MAbs (2017) 0.75
7×7 RMSD matrix: A new method for quantitative comparison of the transmembrane domain structures in the G-protein coupled receptors. J Struct Biol (2017) 0.75
Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. PLoS One (2017) 0.75
Adaptive simulations, towards interactive protein-ligand modeling. Sci Rep (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr (2011) 39.32
Protein homology detection by HMM-HMM comparison. Bioinformatics (2004) 21.92
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
The structure and function of G-protein-coupled receptors. Nature (2009) 8.08
Crystallizing membrane proteins using lipidic mesophases. Nat Protoc (2009) 6.36
Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov (2008) 6.18
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86
CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol (2004) 5.21
Molecular signatures of G-protein-coupled receptors. Nature (2013) 5.19
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev (2000) 4.98
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure (2006) 4.79
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form. Proc Natl Acad Sci U S A (2008) 3.77
Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08
Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci (2011) 2.89
A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science (1995) 2.78
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem (2008) 2.51
Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci U S A (2008) 2.27
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure (2010) 2.10
Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci (1999) 2.04
Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem (2008) 1.94
Thermostabilization of the neurotensin receptor NTS1. J Mol Biol (2009) 1.80
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc Natl Acad Sci U S A (2004) 1.80
Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor. J Mol Biol (2011) 1.54
The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery. Neuropharmacology (2010) 1.52
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations. Proc Natl Acad Sci U S A (2013) 1.46
Molecular basis for negative regulation of the glucagon receptor. Proc Natl Acad Sci U S A (2012) 1.33
Progress in corticotropin-releasing factor-1 antagonist development. Drug Discov Today (2010) 1.32
Automated real-space refinement of protein structures using a realistic backbone move set. Biophys J (2011) 1.16
Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors. PLoS One (2011) 1.16
A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. Mol Pharmacol (2005) 1.10
The use of GPCR structures in drug design. Adv Pharmacol (2011) 1.01
Characterization of parathyroid hormone/receptor interactions: structure of the first extracellular loop. Biochemistry (2000) 1.00
Evolution of exenatide as a diabetes therapeutic. Curr Diabetes Rev (2013) 1.00
Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation. Mol Pharmacol (2010) 0.99
Teriparatide. Nat Rev Drug Discov (2003) 0.98
Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun (1996) 0.97
Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis. J Pharmacol Exp Ther (1998) 0.97
Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor. Biochem Pharmacol (2006) 0.96
Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. J Biol Chem (1996) 0.93
2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem (2008) 0.92
Constitutive activity of glucagon receptor mutants. Mol Endocrinol (1998) 0.92
Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides (2010) 0.90
Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation. Mol Pharmacol (2008) 0.90
Corticotropin releasing hormone--a GPCR drug target. Curr Drug Targets (2007) 0.90
Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. J R Soc Interface (2012) 0.88
Prepublication data sharing. Nature (2009) 12.24
The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem (2002) 5.53
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Structure (2011) 2.84
Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem (2003) 2.52
Knowledge-based real-space explorations for low-resolution structure determination. Structure (2006) 2.52
Progress in structure based drug design for G protein-coupled receptors. J Med Chem (2011) 1.82
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. J Med Chem (2012) 1.60
Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor. J Mol Biol (2011) 1.54
The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery. Neuropharmacology (2010) 1.52
Therapeutic antibodies directed at G protein-coupled receptors. MAbs (2010) 1.41
Outrunning free radicals in room-temperature macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2012) 1.32
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev (2008) 1.27
New insights from structural biology into the druggability of G protein-coupled receptors. Trends Pharmacol Sci (2012) 1.26
Making structural sense of dimerization interfaces of delta opioid receptor homodimers. Biochemistry (2011) 1.13
Identification of novel adenosine A(2A) receptor antagonists by virtual screening. J Med Chem (2012) 1.10
The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med (2012) 1.10
Biophysical mapping of the adenosine A2A receptor. J Med Chem (2011) 1.08
Fragment screening of stabilized G-protein-coupled receptors using biophysical methods. Methods Enzymol (2011) 1.04
Exploring molecular mechanisms of ligand recognition by opioid receptors with metadynamics. Biochemistry (2009) 1.03
The perils of dental vacation: possible anaesthetic and medicolegal consequences. Med Sci Law (2012) 1.01
The use of GPCR structures in drug design. Adv Pharmacol (2011) 1.01
Biophysical fragment screening of the β1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design. J Med Chem (2013) 0.99
Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. DNA Repair (Amst) (2009) 0.98
Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence. Complement Ther Med (2011) 0.97
A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein. Biochemistry (2002) 0.90
Pharmacology and structure of isolated conformations of the adenosine A₂A receptor define ligand efficacy. Mol Pharmacol (2013) 0.89
An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance. Phytother Res (2012) 0.88
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem (2012) 0.87
Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture. J Struct Biol (2004) 0.87
Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals. Mol Ther Nucleic Acids (2012) 0.86
How druggable is protein kinase CK2? Med Res Rev (2010) 0.86
Structure of Class B GPCRs: new horizons for drug discovery. Br J Pharmacol (2014) 0.86
Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA. J Org Chem (2012) 0.86
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors. ChemMedChem (2008) 0.85
Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment. MAbs (2014) 0.84
Fragment screening of GPCRs using biophysical methods: identification of ligands of the adenosine A(2A) receptor with novel biological activity. ACS Chem Biol (2012) 0.84
Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships. J Med Chem (2008) 0.83
The ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water molecules. Chembiochem (2007) 0.83
Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol (2002) 0.82
Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast. Neuropharmacology (2009) 0.82
Fragment-based identification of Hsp90 inhibitors. ChemMedChem (2009) 0.82
NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family. Nature (2012) 0.81
ATP non-competitive Ser/Thr kinase inhibitors as potential anticancer agents. Anticancer Agents Med Chem (2009) 0.80
Purification of Stabilized GPCRs for Structural and Biophysical Analyses. Methods Mol Biol (2015) 0.79
Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast. Psychopharmacology (Berl) (2006) 0.78
Preparation of purified GPCRs for structural studies. Biochem Soc Trans (2013) 0.78
Carbazole-containing arylcarboxamides as BACE1 inhibitors. Bioorg Med Chem Lett (2011) 0.78
GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons. Brain Res (2003) 0.78
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.77
Heterodimerization of gamma-aminobutyric acid B receptor subunits as revealed by the yeast two-hybrid system. Methods (2002) 0.77
Ropivacaine versus levobupivacaine for minor breast surgery in outpatients: inversion of postoperative pain relief efficacy. In Vivo (2012) 0.76
A passivity criterion for sampled-data bilateral teleoperation systems. IEEE Trans Haptics (2014) 0.75
Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov (2017) 0.75
Potential for the Rational Design of Allosteric Modulators of Class C GPCRs. Curr Top Med Chem (2017) 0.75
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem Lett (2009) 0.75
BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides. Bioorg Med Chem (2010) 0.75
Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature (2017) 0.75