Published in Mol Pharmacol on June 23, 2010
Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature (2013) 2.87
Lifting the lid on GPCRs: the role of extracellular loops. Br J Pharmacol (2012) 1.50
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations. Proc Natl Acad Sci U S A (2013) 1.46
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? Br J Pharmacol (2012) 0.97
Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. J R Soc Interface (2012) 0.88
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures. Mol Pharmacol (2015) 0.85
Probing the interaction of SR141716A with the CB1 receptor. J Biol Chem (2012) 0.83
Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling. PLoS One (2011) 0.81
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. J R Soc Interface (2013) 0.80
The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling. Br J Pharmacol (2012) 0.78
Conformational switches in the VPAC(1) receptor. Br J Pharmacol (2012) 0.78
The VPAC1 receptor: structure and function of a class B GPCR prototype. Front Endocrinol (Lausanne) (2012) 0.78
Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies. Front Endocrinol (Lausanne) (2012) 0.78
Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochem Pharmacol (2016) 0.75
Conformational Transitions of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor, a Human Class B GPCR. Sci Rep (2017) 0.75
Fast and accurate predictions of protein stability changes upon mutations using statistical potentials and neural networks: PoPMuSiC-2.0. Bioinformatics (2009) 2.03
GPCR modulation by RAMPs. Pharmacol Ther (2005) 1.85
PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality. BMC Bioinformatics (2011) 1.76
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Mol Pharmacol (2010) 1.49
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations. Proc Natl Acad Sci U S A (2013) 1.46
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol Pharmacol (2005) 1.31
BeAtMuSiC: Prediction of changes in protein-protein binding affinity on mutations. Nucleic Acids Res (2013) 1.21
Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins (2013) 1.20
Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified. J Biol Chem (2007) 1.19
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation. J Biol Chem (2011) 1.19
Enhancing the stability and solubility of TEV protease using in silico design. Protein Sci (2007) 1.17
A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. Mol Pharmacol (2005) 1.10
Specificity and phenetic relationships of iron- and manganese-containing superoxide dismutases on the basis of structure and sequence comparisons. J Biol Chem (2003) 1.09
Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol Sci (2010) 1.07
Modulating receptor function through RAMPs: can they represent drug targets in themselves? Drug Discov Today (2009) 1.07
The pharmacology of adrenomedullin 2/intermedin. Br J Pharmacol (2012) 1.05
Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield. Microb Cell Fact (2009) 1.03
Flavonoids and strigolactones in root exudates as signals in symbiotic and pathogenic plant-fungus interactions. Molecules (2007) 1.02
Structure-activity relationships for α-calcitonin gene-related peptide. Br J Pharmacol (2013) 1.01
Surfactant-free purification of membrane proteins with intact native membrane environment. Biochem Soc Trans (2011) 1.01
Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression. J Biol Chem (2006) 1.01
Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation. Mol Pharmacol (2011) 1.00
The first peptides: the evolutionary transition between prebiotic amino acids and early proteins. J Theor Biol (2009) 0.98
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. Pharmacol Rev (2008) 0.98
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? Br J Pharmacol (2012) 0.97
Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. Biochemistry (2009) 0.97
A conserved cysteine residue is involved in disulfide bond formation between plant plasma membrane aquaporin monomers. Biochem J (2012) 0.96
Sequence-structure signals of 3D domain swapping in proteins. J Mol Biol (2003) 0.96
Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling. J Biol Chem (2005) 0.95
Ectomycorrhizal communities associated with Populus tremula growing on a heavy metal contaminated site. Mycol Res (2008) 0.94
Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges. Endocr Relat Cancer (2010) 0.94
Probing the energetic and structural role of amino acid/nucleobase cation-pi interactions in protein-ligand complexes. J Biol Chem (2002) 0.94
Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein. Protein Sci (2011) 0.93
Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR. Biochemistry (2008) 0.93
Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochim Biophys Acta (2011) 0.93
The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors. J Mol Neurosci (2004) 0.92
The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions. Br J Pharmacol (2003) 0.91
Root anatomy and element distribution vary between two Salix caprea isolates with different Cd accumulation capacities. Environ Pollut (2012) 0.90
Structure-based mutant stability predictions on proteins of unknown structure. J Biotechnol (2012) 0.90
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. J Biol Chem (2011) 0.90
Stair motifs at protein-DNA interfaces: nonadditivity of H-bond, stacking, and cation-pi interactions. J Am Chem Soc (2004) 0.89
Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site. Bioinformatics (2011) 0.89
Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. J R Soc Interface (2012) 0.88
A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells. Br J Pharmacol (2002) 0.88
Thermostability of salt bridges versus hydrophobic interactions in proteins probed by statistical potentials. J Chem Inf Model (2007) 0.88
Development of novel statistical potentials describing cation-pi interactions in proteins and comparison with semiempirical and quantum chemistry approaches. J Chem Inf Model (2006) 0.88
Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. J Pharmacol Exp Ther (2010) 0.88
Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. Br J Pharmacol (2002) 0.87
In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities. J Mol Biol (2003) 0.86
Free-energy calculations of protein-ligand cation-pi and amino-pi interactions: from vacuum to proteinlike environments. J Am Chem Soc (2003) 0.86
Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. Biophys J (2006) 0.86
Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3. J Pharmacol Exp Ther (2009) 0.86
SODa: an Mn/Fe superoxide dismutase prediction and design server. BMC Bioinformatics (2008) 0.86
Thermo- and mesostabilizing protein interactions identified by temperature-dependent statistical potentials. Biophys J (2010) 0.85
Structure-function analysis of RAMP1 by alanine mutagenesis. Biochemistry (2009) 0.85
The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression. J Biol Chem (2005) 0.84
Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin. Regul Pept (2007) 0.84
CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine? Trends Pharmacol Sci (2002) 0.84
Revisiting the correlation between proteins' thermoresistance and organisms' thermophilicity. Protein Eng Des Sel (2008) 0.84
Database-derived potentials dependent on protein size for in silico folding and design. Biophys J (2004) 0.84
Cation-π, amino-π, π-π, and H-bond interactions stabilize antigen-antibody interfaces. Proteins (2014) 0.84
Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides (2009) 0.84
Diverse functional motifs within the three intracellular loops of the CGRP1 receptor. Biochemistry (2006) 0.84
Modeling the temporal evolution of the Drosophila gene expression from DNA microarray time series. Phys Biol (2009) 0.84
Comparative efficacy of VIP and analogs on activation and internalization of the recombinant VPAC2 receptor expressed in CHO cells. Peptides (2004) 0.84
Mn/Fe superoxide dismutase interaction fingerprints and prediction of oligomerization and metal cofactor from sequence. Proteins (2008) 0.84
Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides (2011) 0.83
Robust non-linear differential equation models of gene expression evolution across Drosophila development. BMC Res Notes (2012) 0.83
Detection of perturbation phases and developmental stages in organisms from DNA microarray time series data. PLoS One (2011) 0.83
Mechanism of activation of a G protein-coupled receptor, the human cholecystokinin-2 receptor. J Biol Chem (2007) 0.83
Structure-function studies of muscarinic acetylcholine receptors. Handb Exp Pharmacol (2012) 0.82
Calcitonin gene-related peptide, adrenomedullin and flushing. Maturitas (2009) 0.82
Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture. Br J Pharmacol (2006) 0.81
Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks. Microb Cell Fact (2014) 0.81
The role of the extracellular loops of the CGRP receptor, a family B GPCR. Biochem Soc Trans (2012) 0.81