Defective repair of oxidative base lesions by the DNA glycosylase Nth1 associates with multiple telomere defects.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3715427)

Published in PLoS Genet on July 18, 2013

Authors

Haritha Vallabhaneni1, Nathan O'Callaghan, Julia Sidorova, Yie Liu

Author Affiliations

1: Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.

Articles citing this

Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study. BMJ (2014) 2.26

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet (2014) 2.08

Base excision repair: a critical player in many games. DNA Repair (Amst) (2014) 1.08

The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses. Aging Cell (2014) 1.00

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures. Nucleic Acids Res (2015) 0.97

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation. J Biol Chem (2015) 0.84

Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. Cell Death Dis (2014) 0.83

DNA excision repair at telomeres. DNA Repair (Amst) (2015) 0.81

Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem (2015) 0.80

Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res (2014) 0.80

APE1 incision activity at abasic sites in tandem repeat sequences. J Mol Biol (2014) 0.79

Identifying novel protein phenotype annotations by hybridizing protein-protein interactions and protein sequence similarities. Mol Genet Genomics (2016) 0.78

Defective repair of uracil causes telomere defects in mouse hematopoietic cells. J Biol Chem (2015) 0.77

The origin of oxidized guanine resolves the puzzle of oxidation-induced telomere-length alterations. Nat Struct Mol Biol (2016) 0.75

NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis. Cell Rep (2017) 0.75

Articles cited by this

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19

Switching and signaling at the telomere. Cell (2001) 11.25

Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24

Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74

Base-excision repair of oxidative DNA damage. Nature (2007) 5.44

Telomerase activity in human germline and embryonic tissues and cells. Dev Genet (1996) 5.00

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A (1997) 4.88

ATR regulates fragile site stability. Cell (2002) 4.74

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40

Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol (2012) 3.03

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet (1984) 2.92

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev (2009) 2.91

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun (2012) 2.90

Post-replicative base excision repair in replication foci. EMBO J (1999) 2.86

Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42

Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29

Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitro. Nucleic Acids Res (1986) 2.22

Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res (1998) 2.09

Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci (2000) 1.97

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol (2000) 1.97

Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications. J Biol Chem (1999) 1.93

Role of oxidatively induced DNA lesions in human pathogenesis. Mutat Res (2010) 1.78

A quantitative real-time PCR method for absolute telomere length. Biotechniques (2008) 1.77

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J (2012) 1.73

Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett (1999) 1.69

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J (2012) 1.65

Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal (2010) 1.65

Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59

A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc Natl Acad Sci U S A (2007) 1.56

Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis. Mutat Res (1993) 1.44

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol (2010) 1.44

Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet (2010) 1.41

Strand-specific fluorescence in situ hybridization: the CO-FISH family. Cytogenet Genome Res (2004) 1.41

Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening. Biochemistry (2001) 1.32

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA Repair (Amst) (2009) 1.24

Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair. PLoS Genet (2010) 1.19

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol (2010) 1.17

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17

Hyper telomere recombination accelerates replicative senescence and may promote premature aging. Proc Natl Acad Sci U S A (2010) 1.05

Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J (2009) 1.04

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. Mol Cell Biol (2009) 1.00

Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA. Mutat Res (2000) 0.99

Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. J Biol Chem (2003) 0.95

Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing. Proc Natl Acad Sci U S A (1988) 0.92

A qPCR-based assay to quantify oxidized guanine and other FPG-sensitive base lesions within telomeric DNA. Biotechniques (2011) 0.86

Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. Biochem Biophys Res Commun (2004) 0.85

Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts. J Biol Chem (2002) 0.83

Articles by these authors

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A (2004) 1.83

The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol Cell Biol (2005) 1.49

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol (2006) 1.45

Tumor growth is suppressed in mice expressing a truncated XRCC1 protein. Am J Cancer Res (2012) 1.43

Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet (2010) 1.41

Functional role of the Werner syndrome RecQ helicase in human fibroblasts. Aging Cell (2007) 1.32

B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS One (2008) 1.32

Foreign accent syndrome: a multimodal evaluation in the search of neuroscience-driven treatments. Neuropsychologia (2012) 1.20

An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres. Proc Natl Acad Sci U S A (2005) 1.17

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17

SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep (2013) 1.13

Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. J Cell Biol (2008) 1.09

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Mol Biol Cell (2006) 1.07

Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J (2009) 1.04

RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J Biol Chem (2011) 1.04

Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem (2012) 0.98

Dual-tagging system for the affinity purification of mammalian protein complexes. Biotechniques (2007) 0.97

XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility. Nucleic Acids Res (2011) 0.94

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One (2010) 0.92

Telomere sister chromatid exchange in telomerase deficient murine cells. Cell Cycle (2005) 0.90

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. Proc Natl Acad Sci U S A (2013) 0.88

FANCC suppresses short telomere-initiated telomere sister chromatid exchange. Hum Mol Genet (2009) 0.87

Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor. Proc Natl Acad Sci U S A (2011) 0.86

Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation. J Biol Chem (2007) 0.82

Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis. Aging Cell (2013) 0.78

Telomere, telomerase and aging. Mech Ageing Dev (2007) 0.77

Ultraviolet radiation exposure and serum vitamin D levels in young children. J Paediatr Child Health (2014) 0.75

Quantitative comparison of mitotic spindles by confocal image analysis. J Biomed Opt (2005) 0.75

The monitoring and affinity purification of proteins using dual tags with tetracysteine motifs. Methods Mol Biol (2009) 0.75