Published in PLoS One on July 17, 2013
Systematic identification and analysis of frequent gene fusion events in metabolic pathways. BMC Genomics (2016) 0.75
Genome sequence of the nematode C. elegans: a platform for investigating biology. Science (1998) 61.48
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
The map-based sequence of the rice genome. Nature (2005) 24.17
CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res (2010) 19.07
Detecting protein function and protein-protein interactions from genome sequences. Science (1999) 18.69
Protein interaction maps for complete genomes based on gene fusion events. Nature (1999) 16.48
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol (2002) 8.88
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res (2000) 8.69
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
The vertebrate genome annotation (Vega) database. Nucleic Acids Res (2007) 7.53
Genome sequence of Yersinia pestis KIM. J Bacteriol (2002) 7.14
Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science (2004) 5.64
The genome sequence of the facultative intracellular pathogen Brucella melitensis. Proc Natl Acad Sci U S A (2001) 5.39
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D. Nature (2004) 5.08
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science (2007) 4.89
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science (2005) 4.74
The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science (2002) 4.54
ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res (2007) 3.96
Genomics of the Bacillus cereus group of organisms. FEMS Microbiol Rev (2005) 3.23
Genes linked by fusion events are generally of the same functional category: a systematic analysis of 30 microbial genomes. Proc Natl Acad Sci U S A (2001) 2.95
Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc Natl Acad Sci U S A (2007) 2.79
High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature (2012) 2.55
Domain size distributions can predict domain boundaries. Bioinformatics (2000) 2.43
Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2002) 2.33
Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. PLoS Genet (2009) 2.15
Evolution of the eukaryotic membrane-trafficking system: origin, tempo and mode. J Cell Sci (2007) 1.81
Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions. Genome Biol (2001) 1.76
Pathway evolution, structurally speaking. Curr Opin Struct Biol (2002) 1.44
Resistance gene signaling in plants--complex similarities to animal innate immunity. Curr Opin Immunol (2003) 1.36
Enzymatic mechanism of tRNA (m5U54)methyltransferase. Biochimie (1994) 1.16
Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem (2008) 1.04
Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem (2006) 1.02
An unusual type IB topoisomerase from African trypanosomes. Proc Natl Acad Sci U S A (2003) 1.01
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis. PLoS Pathog (2011) 1.01
Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. FEBS Lett (2005) 0.98
Fusion and fission of genes define a metric between fungal genomes. PLoS Comput Biol (2008) 0.96
Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit. J Biol Chem (2009) 0.94
Structure of the gene encoding human casein kinase II subunit beta. J Biol Chem (1991) 0.92
Denoising inferred functional association networks obtained by gene fusion analysis. BMC Genomics (2007) 0.90
RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential. Mol Biochem Parasitol (2004) 0.90
A unique insertion in Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: evolutionary and functional studies. Mol Biochem Parasitol (2003) 0.89
Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase- 6-phosphogluconolactonase. FEBS J (2006) 0.87
Protein functional links in Trypanosoma brucei, identified by gene fusion analysis. BMC Evol Biol (2011) 0.80
Complete genome sequence of Staphylothermus hellenicus P8. Stand Genomic Sci (2011) 0.78
SAFE Software and FED Database to Uncover Protein-Protein Interactions using Gene Fusion Analysis. Evol Bioinform Online (2011) 0.77
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res (2004) 2.24
HbVar database of human hemoglobin variants and thalassemia mutations: 2007 update. Hum Mutat (2007) 2.22
Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia. Mol Biol Evol (2004) 1.74
The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem Sci (2003) 1.72
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet (2010) 1.72
Using graph theory to analyze biological networks. BioData Min (2011) 1.54
Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev (2007) 1.36
Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood (2010) 1.21
jClust: a clustering and visualization toolbox. Bioinformatics (2009) 1.20
Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts. Bone (2004) 1.10
Novel sources of fetal stem cells: where do they fit on the developmental continuum? Regen Med (2009) 1.07
Survivin -31G/C promoter polymorphism and sporadic colorectal cancer. Int J Colorectal Dis (2008) 1.07
Search for potential markers for prostate cancer diagnosis, prognosis and treatment in clinical tissue specimens using amine-specific isobaric tagging (iTRAQ) with two-dimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2008) 1.05
Plant cytosine-5 DNA methyltransferases: structure, function, and molecular evolution. Genomics (2007) 1.03
Characterization of the human urine proteome by preparative electrophoresis in combination with 2-DE. Proteomics (2006) 1.03
Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application. BMC Bioinformatics (2009) 1.00
Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status. Gynecol Oncol (2005) 0.99
Sox2 suppression by miR-21 governs human mesenchymal stem cell properties. Stem Cells Transl Med (2013) 0.97
Persistent gamma-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences. Blood (2003) 0.96
Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population. Gynecol Endocrinol (2010) 0.94
Amniotic fluid and amniotic membrane stem cells: marker discovery. Stem Cells Int (2012) 0.94
OCT4 spliced variant OCT4B1 is expressed in human colorectal cancer. Mol Carcinog (2011) 0.93
In vitro and in vivo properties of distinct populations of amniotic fluid mesenchymal progenitor cells. J Cell Mol Med (2011) 0.93
Sample preparation and bioinformatics in MALDI profiling of urinary proteins. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.92
Characterization and comparative performance of lentiviral vector preparations concentrated by either one-step ultrafiltration or ultracentrifugation. Virus Res (2013) 0.92
Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One (2013) 0.92
Which clustering algorithm is better for predicting protein complexes? BMC Res Notes (2011) 0.90
Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases. Genomics (2009) 0.90
Introducing Drugster: a comprehensive and fully integrated drug design, lead and structure optimization toolkit. Bioinformatics (2012) 0.90
Major challenges for gene therapy of thalassemia and sickle cell disease. Curr Gene Ther (2010) 0.90
Analysis of secreted proteins for the study of bladder cancer cell aggressiveness. J Proteome Res (2010) 0.89
Human amniotic fluid stem cells as an attractive tool for clinical applications. Curr Stem Cell Res Ther (2013) 0.88
Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus. Comput Math Methods Med (2013) 0.88
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. World J Gastroenterol (2005) 0.88
An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease. PLoS One (2012) 0.87
GIBA: a clustering tool for detecting protein complexes. BMC Bioinformatics (2009) 0.87
Human gene correlation analysis (HGCA): a tool for the identification of transcriptionally co-expressed genes. BMC Res Notes (2012) 0.86
Noise reduction in protein-protein interaction graphs by the implementation of a novel weighting scheme. BMC Bioinformatics (2011) 0.86
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target. PeerJ (2013) 0.86
Role of functional polymorphisms of NRAMP1 gene for the development of Crohn's disease. Inflamm Bowel Dis (2008) 0.86
Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer. Stem Cells Dev (2011) 0.86
5-HT2A receptor gene polymorphisms and irritable bowel syndrome. J Clin Gastroenterol (2011) 0.85
Evaluation of the Zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles. PLoS One (2012) 0.85
Serum protein profile of Crohn's disease treated with infliximab. J Crohns Colitis (2013) 0.84
Persistent fetal gamma-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Agamma-globin gene. Mol Med (2009) 0.84
Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. Genomics (2002) 0.84
Proteomics-driven progress in neurodegeneration research. Electrophoresis (2006) 0.84
An embryonic-specific repressor element located 3' to the Agamma-globin gene influences transcription of the human beta-globin locus in transgenic mice. Exp Hematol (2004) 0.83
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J Gastroenterol (2010) 0.83
Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer. Proteomics (2009) 0.83
A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase. PeerJ (2013) 0.83
The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus. Diabetes Res Clin Pract (2012) 0.82
Gestational diabetes exhibits lack of carnitine deficiency despite relatively low carnitine levels and alterations in ketogenesis. J Matern Fetal Neonatal Med (2005) 0.81
Platelet-rich plasma (PRP) promotes fetal mesenchymal stem/stromal cell migration and wound healing process. Stem Cell Rev (2014) 0.81
Antiviral Stratagems Against HIV-1 Using RNA Interference (RNAi) Technology. Evol Bioinform Online (2013) 0.81
Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection. World J Gastroenterol (2012) 0.81
Expression profiling of vulvar carcinoma: clues for deranged extracellular matrix remodeling and effects on multiple signaling pathways combined with discrete patient subsets. Transl Oncol (2011) 0.80
3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target. Influenza Res Treat (2013) 0.80
Protein functional links in Trypanosoma brucei, identified by gene fusion analysis. BMC Evol Biol (2011) 0.80
The new self-inactivating lentiviral vector for thalassemia gene therapy combining two HPFH activating elements corrects human thalassemic hematopoietic stem cells. Hum Gene Ther (2011) 0.80
Phylogenetic and regulatory region analysis of Wnt5 genes reveals conservation of a regulatory module with putative implication in pancreas development. Biol Direct (2010) 0.80
On integrating multi-experiment microarray data. Philos Trans A Math Phys Eng Sci (2014) 0.80
State-of-the-art technology in modern computer-aided drug design. Brief Bioinform (2012) 0.80
Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. FEBS J (2010) 0.79
Circadian clock gene expression is impaired in gestational diabetes mellitus. Gynecol Endocrinol (2013) 0.79
Protein signatures using electrostatic molecular surfaces in harmonic space. PeerJ (2013) 0.79
Evolutionary scenarios of Notch proteins. Mol Biol Evol (2009) 0.79
Emerging issues of the expression profiling technologies for the study of gynecologic cancer. Am J Obstet Gynecol (2005) 0.78
Functional role of the four different types of (AT)(x)T(y) motifs 5' to the beta-globin gene and their distribution in the Greek population. Blood Cells Mol Dis (2002) 0.78
Transcriptome map of mouse isochores. BMC Genomics (2011) 0.78
Fusion methodologies for biomedical data. J Proteomics (2011) 0.78
Association of the dopamine D3 receptor Ser9Gly and of the serotonin 2C receptor gene polymorphisms with tardive dyskinesia in Greeks with chronic schizophrenic disorder. Psychiatr Genet (2009) 0.77
Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model. Blood Cells Mol Dis (2009) 0.77
'Brukin2D': a 2D visualization and comparison tool for LC-MS data. BMC Bioinformatics (2009) 0.77
SAFE Software and FED Database to Uncover Protein-Protein Interactions using Gene Fusion Analysis. Evol Bioinform Online (2011) 0.77
Transcription factor ATF-3 regulates allele variation phenotypes of the human SLC11A1 gene. Mol Biol Rep (2012) 0.77
Dynamic retrotransposition of ERV-9 LTR and L1 in the beta-globin gene locus during primate evolution. Mol Phylogenet Evol (2004) 0.76
Compositional perspectives on human brain aging. Biosystems (2011) 0.76
Antibody Drug Conjugate bioinformatics: drug delivery through the letterbox. Comput Math Methods Med (2013) 0.76
IMGT/Collier-de-Perles: a two-dimensional visualization tool for amino acid domain sequences. Theor Biol Med Model (2013) 0.76
Notch signaling and ageing. Adv Exp Med Biol (2015) 0.76
Cytosine methyltransferases as tumor markers. Curr Genomics (2010) 0.76
Polymorphism Analysis of VSX1 and SOD1 Genes in Greek Patients with Keratoconus. Ophthalmic Genet (2015) 0.76
Variable effects of maternal and paternal-fetal contribution to the risk for preeclampsia combining GSTP1, eNOS, and LPL gene polymorphisms. J Matern Fetal Neonatal Med (2010) 0.75
Maternal and fetal circulating sKL and ET-1 levels as function of normal labor at term. J Matern Fetal Neonatal Med (2010) 0.75
The 20th anniversary of EMBnet: 20 years of bioinformatics for the Life Sciences community. BMC Bioinformatics (2009) 0.75
The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia. Stem Cells Int (2011) 0.75
Design, synthesis and application of benzyl-sulfonate biomimetic affinity adsorbents for monoclonal antibody purification from transgenic corn. J Mol Recognit (2014) 0.75
A computer-based technique for automated spot detection in proteomics images. IEEE Trans Inf Technol Biomed (2011) 0.75
Low serum gamma-glutamyltranspeptidase (GGT) in patients with chronic idiopathic neutropenia is not implicated in the pathophysiology of the disease. Haematologica (2003) 0.75
e-Herophilus: 24-hour personalised telecardiology services. Int J Electron Healthc (2010) 0.75
Unraveling microalgal molecular interactions using evolutionary and structural bioinformatics. Gene (2013) 0.75
Web-based tools for protein classification. Methods Mol Biol (2008) 0.75
Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation. Genomics (2012) 0.75