Published in J Biol Chem on November 03, 2006
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature (2014) 2.11
Expanding the nucleotide repertoire of the ribosome with post-transcriptional modifications. ACS Chem Biol (2007) 1.73
Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. Nucleic Acids Res (2010) 1.01
Unveiling substrate RNA binding to H/ACA RNPs: one side fits all. Curr Opin Struct Biol (2008) 0.97
RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA. RNA (2007) 0.93
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J Mol Biol (2009) 0.90
Pseudouridine: still mysterious, but never a fake (uridine)! RNA Biol (2014) 0.89
Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. RNA (2008) 0.89
The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA. Nucleic Acids Res (2014) 0.87
Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs. Mol Cell Biol (2008) 0.84
Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases. RNA (2010) 0.84
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res (2013) 0.82
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J Mol Biol (2015) 0.82
Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET. RNA (2010) 0.79
Gene fusion analysis in the battle against the African endemic sleeping sickness. PLoS One (2013) 0.75
Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science (2002) 5.78
Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science (2004) 5.42
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Substrate twinning activates the signal recognition particle and its receptor. Nature (2004) 2.91
The channel architecture of aquaporin 0 at a 2.2-A resolution. Proc Natl Acad Sci U S A (2004) 2.69
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure (2006) 2.40
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proc Natl Acad Sci U S A (2009) 2.28
Targeting proteins to membranes: structure of the signal recognition particle. Curr Opin Struct Biol (2005) 2.18
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol (2003) 2.11
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc Natl Acad Sci U S A (2006) 1.85
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A. Proc Natl Acad Sci U S A (2005) 1.81
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science (2007) 1.77
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol (2012) 1.75
Mechanism of association and reciprocal activation of two GTPases. PLoS Biol (2004) 1.72
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol (2008) 1.68
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry (2003) 1.67
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (2003) 1.67
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A (2003) 1.65
A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Cell (2005) 1.63
Crystal structure of a eukaryotic phosphate transporter. Nature (2013) 1.60
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc Natl Acad Sci U S A (2010) 1.57
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry (2002) 1.45
Function of human Rh based on structure of RhCG at 2.1 A. Proc Natl Acad Sci U S A (2010) 1.41
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol (2003) 1.40
Structural basis of aquaporin inhibition by mercury. J Mol Biol (2007) 1.35
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci U S A (2008) 1.35
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci U S A (2004) 1.30
Comparison of human solute carriers. Protein Sci (2010) 1.29
Fabs enable single particle cryoEM studies of small proteins. Structure (2012) 1.25
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A (2014) 1.23
Structure of sugar-bound LacY. Proc Natl Acad Sci U S A (2014) 1.23
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A (2008) 1.22
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem (2002) 1.22
A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nat Protoc (2009) 1.21
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (2002) 1.21
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A. J Biol Chem (2005) 1.19
Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. J Biol Chem (2003) 1.16
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Mol Cell (2007) 1.15
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol (2011) 1.14
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A (2009) 1.14
Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. PLoS One (2010) 1.13
Structural and functional basis for RNA cleavage by Ire1. BMC Biol (2011) 1.12
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. Structure (2003) 1.11
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J Am Chem Soc (2012) 1.08
Structural context shapes the aquaporin selectivity filter. Proc Natl Acad Sci U S A (2010) 1.06
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol (2013) 1.05
Cell-free complements in vivo expression of the E. coli membrane proteome. Protein Sci (2007) 1.05
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Structure (2004) 1.04
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction. Physiology (Bethesda) (2006) 1.03
Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature (2013) 1.03
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems. Proc Natl Acad Sci U S A (2010) 1.03
Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells. Nat Protoc (2012) 1.03
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol (2003) 1.03
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. J Mol Biol (2008) 1.02
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry (2002) 1.01
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution. Nucleic Acids Res (2007) 0.99
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A (2011) 0.96
Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. J Synchrotron Radiat (2003) 0.95
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry (2002) 0.93
Rapid identification of recombinant Fabs that bind to membrane proteins. Methods (2011) 0.92
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus. PLoS One (2008) 0.91
Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies. J Biol Chem (2004) 0.90
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. PLoS One (2007) 0.90
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J Mol Biol (2009) 0.90
A survey of integral alpha-helical membrane proteins. J Struct Funct Genomics (2009) 0.89
Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc (2013) 0.89
Overexpression and purification of integral membrane proteins in yeast. Methods Enzymol (2010) 0.87
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. PLoS One (2008) 0.86
The crystal structure of E. coli rRNA pseudouridine synthase RluE. J Mol Biol (2007) 0.84
Structure of human pro-chymase: a model for the activating transition of granule-associated proteases. Biochemistry (2003) 0.84
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J Med Chem (2012) 0.83
LpxI structures reveal how a lipid A precursor is synthesized. Nat Struct Mol Biol (2012) 0.83
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res (2013) 0.82
Structure-based studies on species-specific inhibition of thymidylate synthase. Biochim Biophys Acta (2002) 0.82
De novo design of an IL-4 antagonist and its structure at 1.9 A. Proc Natl Acad Sci U S A (2005) 0.81
Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells. Methods (2011) 0.81
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. PLoS One (2012) 0.81
Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter. Proc Natl Acad Sci U S A (2013) 0.79
The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme. J Eukaryot Microbiol (2003) 0.79
Crystal structure of bovine mitochondrial factor B at 0.96-A resolution. Proc Natl Acad Sci U S A (2008) 0.79
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng (2003) 0.79
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr (2005) 0.79
General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays. Curr Protoc Protein Sci (2014) 0.78