Published in PLoS One on July 18, 2013
A simple method for organotypic cultures of nervous tissue. J Neurosci Methods (1991) 14.18
Ischemic cell death in brain neurons. Physiol Rev (1999) 8.01
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70
Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology (2007) 3.82
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet (1987) 2.50
Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res (1995) 2.46
An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun (2006) 2.31
Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke (2011) 2.23
The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Intern Med (2000) 2.14
11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev (1997) 1.91
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci (2006) 1.68
How to close a gap junction channel. Efficacies and potencies of uncoupling agents. Methods Mol Biol (2001) 1.61
Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions. J Physiol (2003) 1.59
11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics. Proc Natl Acad Sci U S A (2004) 1.52
Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury. J Neurosci (2002) 1.43
11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology (1995) 1.38
Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke (2005) 1.36
11 beta-Hydroxysteroid dehydrogenase. Vitam Horm (1999) 1.34
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res (1992) 1.34
Stress-related modulation of hippocampal long-term potentiation in rats: Involvement of adrenal steroid receptors. J Neurosci (2003) 1.30
Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats. Brain Res (2006) 1.25
Ischemia-induced brain damage depends on specific gap-junctional coupling. J Cereb Blood Flow Metab (2002) 1.24
Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Proc Natl Acad Sci U S A (2001) 1.20
Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg (1997) 1.18
The role of 11beta-hydroxysteroid dehydrogenases in the brain. Mol Cell Endocrinol (2006) 1.18
11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. Front Neuroendocrinol (2010) 1.13
Emerging mechanisms of disrupted cellular signaling in brain ischemia. Nat Neurosci (2011) 1.11
Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia. J Biol Chem (2005) 1.09
Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess. Proc Natl Acad Sci U S A (1999) 1.05
11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci (1996) 1.05
Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing. J Cereb Blood Flow Metab (2010) 1.02
Pathophysiology of modulation of local glucocorticoid levels by 11beta-hydroxysteroid dehydrogenases. Trends Endocrinol Metab (2001) 1.00
Gap-junction blocker carbenoxolone differentially enhances NMDA-induced cell death in hippocampal neurons and astrocytes in co-culture. J Neurochem (2007) 0.93
In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons. J Neurosci (1997) 0.92
Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. Stroke (2004) 0.92
Carbenoxolone does not cross the blood brain barrier: an HPLC study. BMC Neurosci (2006) 0.89
A neuroprotective role for gap junctions. Cell Commun Adhes (2001) 0.89
Distribution of 11 beta-hydroxysteroid dehydrogenase along the rabbit nephron. J Clin Invest (1990) 0.82
Effect of central microinjection of carbenoxolone in an experimental model of focal cerebral ischemia. Pak J Pharm Sci (2009) 0.81
Inhibition of renal 11beta-hydroxysteroid dehydrogenase in vivo by carbenoxolone in the rat and its relationship to sodium excretion. Clin Sci (Lond) (1998) 0.81
Conversion of cortisol to cortisol acetate, cortisone acetate and cortisone by the developing primate brain. Steroids (1968) 0.79
Attenuation of Hippocampal 11beta-Hydroxysteroid Dehydrogenase Type 1 by Chronic Psychosocial Stress in the Tree Shrew. Stress (1997) 0.78
Critical care of acute ischemic stroke. Crit Care Clin (2006) 0.78
11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary cells: specific inhibition by 11 alpha-hydroxyprogesterone. Endocrinology (1996) 0.78
Glycyrrhetinic acid, an inhibitor of 11 beta-hydroxysteroid dehydrogenase, alters local cerebral glucose utilization in vivo. J Steroid Biochem Mol Biol (1991) 0.77
11-beta-Hydroxysteroid metabolism by mouse brain and glioma 261. J Neurochem (1966) 0.77
THE IN VITRO CONVERSION OF CORTISOL TO CORTISONE BY SUBCELLULAR BRAIN FRACTIONS OF YOUNG AND ADULT RATS. J Neurochem (1965) 0.77
Peripheral administration of carbenoxolone reduces ischemic reperfusion injury in transient model of cerebral ischemia. J Stroke Cerebrovasc Dis (2009) 0.77
Identification of a central role for complement in osteoarthritis. Nat Med (2011) 3.11
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med (2003) 2.35
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. FEBS J (2009) 2.14
Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity. Neuron (2009) 2.11
Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron (2003) 1.95
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest (2013) 1.83
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A (2011) 1.63
Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells (2011) 1.54
Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP). Eur J Neurosci (2006) 1.52
GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion. Oncogene (2005) 1.43
Mechanisms of neural plasticity following brain injury. Curr Opin Neurobiol (2006) 1.42
A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci (2013) 1.35
Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc Natl Acad Sci U S A (2011) 1.26
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. J Neurosci (2011) 1.20
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain (2011) 1.18
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci (2012) 1.17
Long-term behavioral assessment of function in an experimental model for ischemic stroke. J Neurosci Methods (2011) 1.16
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav (2012) 1.15
FoxO6 regulates memory consolidation and synaptic function. Genes Dev (2012) 1.14
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis (2011) 1.09
Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia. J Biol Chem (2005) 1.09
KIBRA: A New Gateway to Learning and Memory? Front Aging Neurosci (2010) 1.09
Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Cancer Res (2006) 1.08
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. J Biol Chem (2003) 1.08
Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. Eur J Neurosci (2006) 1.07
LRRK2 in Parkinson's disease: biochemical functions. FEBS J (2009) 1.04
Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders. PLoS One (2012) 1.03
TNFalpha-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity? Neuron Glia Biol (2004) 1.02
Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2. J Neurooncol (2006) 1.02
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. J Neurosci (2013) 1.00
A high-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity. J Biomol Screen (2004) 0.98
Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. Future Med Chem (2011) 0.98
Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. PLoS One (2010) 0.96
FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS. J Neurooncol (2005) 0.95
GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. Neuropsychopharmacology (2013) 0.93
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia. Eur J Neurosci (2008) 0.91
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease. Neurotherapeutics (2013) 0.90
The asparaginyl endopeptidase legumain after experimental stroke. J Cereb Blood Flow Metab (2010) 0.88
Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor. Synapse (2012) 0.88
Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy. Expert Opin Ther Targets (2004) 0.87
A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models. J Neurosci (2014) 0.87
Sex-specific cognitive deficits and regional brain volume loss in mice exposed to chronic, sublethal hypoxia. Pediatr Res (2011) 0.86
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion. J Cereb Blood Flow Metab (2004) 0.84
Persistent phosphorylation of synaptic proteins following middle cerebral artery occlusion. J Cereb Blood Flow Metab (2002) 0.83
Optimizing the use of CROs by academia and small companies. Nat Rev Drug Discov (2013) 0.80
Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model. Brain Behav (2012) 0.79
Computational analysis of stresses acting on intermodular junctions in thoracic aortic endografts. J Endovasc Ther (2011) 0.78
High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus. Bioorg Med Chem Lett (2003) 0.78
Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment. Neuro Oncol (2005) 0.77
Conspecific discrimination in an object-choice task in African grey parrots (Psittacus erithacus). Behav Processes (2009) 0.77
Intraoperative Optical Coherence Tomography-Assisted Descemet Stripping Automated Endothelial Keratoplasty for Anterior Chamber Fibrous Ingrowth. Cornea (2017) 0.75
Linking solubility and permeability assays for maximum throughput and reproducibility. J Biomol Screen (2005) 0.75