Published in Immunity on July 25, 2013
Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nat Immunol (2016) 1.52
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A (2014) 1.15
A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol (2014) 1.04
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med (2014) 0.99
GATA3: a master of many trades in immune regulation. Trends Immunol (2014) 0.96
Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Rα-independent alternative differentiation of macrophages. PLoS Pathog (2013) 0.93
Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling. Nat Immunol (2015) 0.91
Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors. Annu Rev Immunol (2015) 0.87
Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86
Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway. Inflammation (2014) 0.85
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. Cytokine (2015) 0.84
Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells. Proc Natl Acad Sci U S A (2016) 0.82
The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation. J Immunol (2015) 0.82
Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells. PLoS One (2014) 0.82
Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling. Proc Natl Acad Sci U S A (2014) 0.81
Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol (2015) 0.80
Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation. J Immunol (2015) 0.80
CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study. Arthritis Res Ther (2015) 0.79
Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome. Blood (2014) 0.78
Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep (2015) 0.77
Targeted approaches to induce immune tolerance for Pompe disease therapy. Mol Ther Methods Clin Dev (2016) 0.77
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep (2016) 0.76
Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. Int J Mol Sci (2016) 0.76
Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner. Sci Rep (2016) 0.75
Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response. Front Immunol (2016) 0.75
Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Front Immunol (2017) 0.75
Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis. MBio (2016) 0.75
The Regulatory Function of Eosinophils. Microbiol Spectr (2016) 0.75
Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection. J Immunol (2017) 0.75
Programming of donor T cells using allogeneic δ-like ligand 4-positive dendritic cells to reduce GVHD in mice. Blood (2016) 0.75
Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier? Front Immunol (2017) 0.75
Notch Signaling and Alloreactivity. Transplantation (2016) 0.75
Notch controls effector CD8+ T cell differentiation. Oncotarget (2015) 0.75
T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection. J Immunol (2017) 0.75
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med (2006) 3.36
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science (2005) 3.32
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity (2009) 3.24
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12
Notch signaling in the immune system. Immunity (2010) 3.00
Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med (1994) 2.90
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Notch signaling is an important regulator of type 2 immunity. J Exp Med (2005) 2.87
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol (2005) 2.81
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol (2000) 2.80
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med (2009) 2.45
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity (2003) 2.34
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99
The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol (2012) 1.97
The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Adv Parasitol (2004) 1.93
CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med (2007) 1.86
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol (2009) 1.61
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol (2009) 1.51
Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. J Immunol (2002) 1.31
Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood (2011) 1.30
T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A (2005) 1.22
Notch signaling regulates mouse and human Th17 differentiation. J Immunol (2011) 1.21
Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. J Immunol (2009) 1.21
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood (2010) 1.21
Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity (2012) 1.19
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity (2010) 1.17
T follicular helper cell diversity and plasticity. Trends Immunol (2013) 1.14
The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity (2012) 1.14
B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris. Infect Immun (2001) 1.05
Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A (2012) 0.99
Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathog (2012) 0.97
Notch: filling a hole in T helper 2 cell differentiation. Immunity (2007) 0.92
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91
IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature (2009) 8.71
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol (2011) 6.73
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature (2010) 5.07
Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature (2007) 4.68
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol (2011) 4.64
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Reciprocal interactions of the intestinal microbiota and immune system. Nature (2012) 4.42
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (2012) 4.20
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity (2010) 4.19
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev (2005) 4.08
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology (2007) 3.82
Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol (2006) 3.78
The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature (2009) 3.75
Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol (2005) 3.58
Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity (2012) 3.47
IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol (2010) 3.43
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med (2006) 3.36
Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol Rev (2008) 3.33
Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol (2005) 3.26
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010) 3.24
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature (2013) 3.21
Notch signaling in leukemia. Annu Rev Pathol (2008) 3.21
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
The multifaceted role of Notch in cancer. Curr Opin Genet Dev (2006) 3.07
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med (2013) 2.94
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 2.90
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Notch signaling is an important regulator of type 2 immunity. J Exp Med (2005) 2.87
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity (2012) 2.87
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med (2009) 2.78
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood (2007) 2.77
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest (2008) 2.73
Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol (2010) 2.72
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol (2012) 2.70
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol (2009) 2.65
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med (2013) 2.64
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med (2008) 2.63
Memory CD4 T cells emerge from effector T-cell progenitors. Nature (2008) 2.62
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol (2010) 2.58
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol (2009) 2.53
Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum (2003) 2.53
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med (2009) 2.51
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med (2012) 2.49
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med (2009) 2.45
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature (2011) 2.42
Regulation of pathogenesis and immunity in helminth infections. J Exp Med (2009) 2.39
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med (2010) 2.30
New paradigms in type 2 immunity. Science (2012) 2.27
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Notch signaling in cancer. Cancer Biol Ther (2002) 2.20
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.16
Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity (2011) 2.15
A critical role for TCF-1 in T-lineage specification and differentiation. Nature (2011) 2.15
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J Exp Med (2006) 2.02
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity (2013) 2.01
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A (2007) 1.98
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A (2011) 1.98
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood (2005) 1.96
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol (2006) 1.94
Commensal bacteria at the interface of host metabolism and the immune system. Nat Immunol (2013) 1.93
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood (2010) 1.92
Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing. Infect Immun (2009) 1.91
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol (2013) 1.91
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88
Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J Exp Med (2003) 1.87
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol (2006) 1.79
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell (2006) 1.76
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol (2006) 1.75
Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity (2012) 1.73