Published in Immunity on May 13, 2010
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The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol (2010) 6.02
Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98
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Th17 cells can provide B cell help in autoantibody induced arthritis. J Autoimmun (2010) 0.94
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Conserved intergenic elements and DNA methylation cooperate to regulate transcription at the il17 locus. J Biol Chem (2012) 0.93
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Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity (2015) 0.91
Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis. Front Syst Neurosci (2012) 0.90
T cell immunity as a tool for studying epigenetic regulation of cellular differentiation. Front Genet (2013) 0.89
Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. PLoS Pathog (2012) 0.89
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem (2013) 0.88
Epigenomics of idiopathic pulmonary fibrosis. Epigenomics (2012) 0.88
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion. Sci Rep (2015) 0.88
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol (2013) 0.88
Immunity by equilibrium. Nat Rev Immunol (2016) 0.88
TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu. Front Immunol (2013) 0.87
Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution. Pulm Circ (2014) 0.85
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T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine. Nat Commun (2016) 0.84
The roles of IFN-γ versus IL-17 in pathogenic effects of human Th17 cells on synovial fibroblasts. Mod Rheumatol (2013) 0.84
Of mice and men: how animal models advance our understanding of T-cell function in RA. Nat Rev Rheumatol (2014) 0.84
TET proteins and 5-methylcytosine oxidation in the immune system. Cold Spring Harb Symp Quant Biol (2014) 0.84
The chromatin landscape and transcription factors in T cell programming. Trends Immunol (2014) 0.83
Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis. J Immunol (2011) 0.83
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation. J Immunol (2014) 0.83
Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for? Open Biol (2013) 0.83
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells. Immunity (2014) 0.83
The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. Cytokine (2013) 0.83
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. J Neuroinflammation (2015) 0.82
Epigenetic regulation: the interface between prenatal and early-life exposure and asthma susceptibility. Environ Mol Mutagen (2013) 0.81
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling. Clin Cancer Res (2015) 0.81
Histone methyltransferase and histone methylation in inflammatory T-cell responses. Immunotherapy (2013) 0.81
Harnessing the Therapeutic Potential of Th17 Cells. Mediators Inflamm (2015) 0.80
Th17 cells demonstrate stable cytokine production in a proallergic environment. J Immunol (2014) 0.80
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Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis. Brain Behav Immun (2014) 0.80
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The inducible costimulator augments Tc17 cell responses to self and tumor tissue. J Immunol (2015) 0.80
Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet (2014) 0.80
TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS One (2014) 0.79
Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect. J Immunol (2014) 0.79
Astrocytes modulate the polarization of CD4+ T cells to Th1 cells. PLoS One (2014) 0.79
Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells. PLoS One (2014) 0.79
Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene. PLoS One (2013) 0.79
Epigenetic regulation of IL-12-dependent T cell proliferation. J Leukoc Biol (2015) 0.79
Exploiting IL-17-producing CD4(+) and CD8(+) T cells to improve cancer immunotherapy in the clinic. Cancer Immunol Immunother (2016) 0.79
Inflammation as a Therapeutic Target for Diabetic Neuropathies. Curr Diab Rep (2016) 0.78
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Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals. Biology (Basel) (2015) 0.77
T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin. Biomed Res Int (2015) 0.77
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Chromatin modifications and their function. Cell (2007) 55.98
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
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Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
VISTA: computational tools for comparative genomics. Nucleic Acids Res (2004) 13.52
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Genome regulation by polycomb and trithorax proteins. Cell (2007) 11.96
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature (2008) 10.15
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature (2008) 9.32
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Methods (2006) 6.25
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96
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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A (2006) 5.69
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest (2009) 4.74
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol (2008) 3.88
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature (2009) 3.75
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol (2009) 3.42
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A (2008) 3.34
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem (2007) 3.14
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A (2004) 2.21
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A (2008) 2.13
Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol (2008) 2.09
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The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev (2003) 1.82
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Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip). Methods Mol Biol (2009) 1.33
Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci U S A (2009) 1.30
Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development. Blood (2003) 1.18
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
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Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
High-resolution mapping and characterization of open chromatin across the genome. Cell (2008) 15.93
IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99
Evidence for nucleosome depletion at active regulatory regions genome-wide. Nat Genet (2004) 9.10
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DNase I sensitivity QTLs are a major determinant of human expression variation. Nature (2012) 6.17
Heritable individual-specific and allele-specific chromatin signatures in humans. Science (2010) 5.94
Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. PLoS Genet (2007) 5.93
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RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Methods (2013) 4.85
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High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res (2010) 4.69
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res (2011) 4.43
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Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Mol Cell Biol (2005) 3.83
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology (2007) 3.82
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol (2005) 3.79
Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol (2006) 3.78
The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature (2009) 3.75
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DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb Protoc (2010) 3.54
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Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet (2006) 2.62
Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol (2009) 2.53
Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum (2003) 2.53
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Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20
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T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med (2002) 1.69
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TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
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Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect Immun (2011) 1.58
Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab (2008) 1.55
Site-specific silencing of regulatory elements as a mechanism of X inactivation. Cell (2012) 1.54
Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. Genome Res (2011) 1.53
Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell (2005) 1.50
Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol (2002) 1.49
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J Cell Sci (2012) 1.48
IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol (2013) 1.45
Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J Immunol (2002) 1.44
Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol (2011) 1.40
The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 1.38
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci U S A (2013) 1.37
Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. EMBO J (2006) 1.36
Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis. Gastroenterology (2011) 1.35
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. Cancer Res (2007) 1.34
Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip). Methods Mol Biol (2009) 1.33
CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A (2007) 1.30
Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A (2009) 1.29
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med (2009) 1.27
Intestinal effector T cells in health and disease. Immunity (2009) 1.24
A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. J Cell Mol Med (2009) 1.23
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity (2012) 1.22
Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet (2012) 1.22
IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res (2003) 1.21
Autoimmunity: increasing suspects in the CD4+ T cell lineup. Nat Immunol (2009) 1.21
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity (2013) 1.20