Published in Nature on April 30, 2006
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med (2006) 13.74
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Phenotypic and functional features of human Th17 cells. J Exp Med (2007) 11.33
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
Inflammatory bowel disease. N Engl J Med (2009) 8.62
A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 8.54
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med (2006) 7.87
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
CD4 T cells: fates, functions, and faults. Blood (2008) 7.03
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature (2008) 7.00
Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Structure and signalling in the IL-17 receptor family. Nat Rev Immunol (2009) 6.38
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol (2008) 5.92
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 5.76
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity (2007) 5.73
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med (2007) 5.58
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol (2011) 5.41
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med (2010) 4.78
Th17: the third member of the effector T cell trilogy. Curr Opin Immunol (2007) 4.78
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med (2008) 4.76
Follicular helper T cells: lineage and location. Immunity (2009) 4.75
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest (2009) 4.74
Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov (2012) 4.70
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol (2009) 4.69
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
Induction and molecular signature of pathogenic TH17 cells. Nat Immunol (2012) 4.43
Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30
Th17 cells in human disease. Immunol Rev (2008) 4.27
Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity (2010) 4.19
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (2008) 4.04
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest (2008) 3.90
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol (2008) 3.88
Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med (2008) 3.85
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog (2010) 3.76
The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol (2010) 3.75
IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med (2007) 3.68
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology (2011) 3.52
Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol (2008) 3.42
Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev (2010) 3.41
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2011) 3.32
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med (2007) 3.29
Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature (2009) 3.25
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol (2009) 3.23
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol (2008) 3.22
Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol (2008) 3.19
Th17 cells and mucosal host defense. Semin Immunol (2007) 3.17
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res (2008) 3.09
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
gammadelta T cells: an important source of IL-17. Curr Opin Immunol (2008) 3.03
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol (2009) 3.01
CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol (2009) 3.00
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med (2009) 2.96
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol (2010) 2.94
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A (2007) 2.92
Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol (2008) 2.90
Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol (2013) 2.89
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity (2012) 2.87
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest (2008) 2.82
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82
Th17 cells: effector T cells with inflammatory properties. Semin Immunol (2007) 2.81
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation (2009) 2.77
The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol (2010) 2.74
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest (2008) 2.66
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99
Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity (2006) 10.53
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med (2004) 7.93
Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
Reciprocal interactions of the intestinal microbiota and immune system. Nature (2012) 4.42
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev (2005) 4.08
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell (2002) 4.08
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology (2007) 3.82
Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol (2006) 3.78
The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature (2009) 3.75
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology (2005) 3.41
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010) 3.24
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature (2013) 3.21
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity (2012) 2.87
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Exp Med (2006) 2.83
IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med (2009) 2.78
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A (2009) 2.77
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene (2002) 2.74
Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol (2009) 2.74
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol (2009) 2.65
Memory CD4 T cells emerge from effector T-cell progenitors. Nature (2008) 2.62
Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol (2009) 2.53
Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum (2003) 2.53
Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. J Immunol (2002) 2.26
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev (2003) 2.20
Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation (2009) 2.19
Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity (2011) 2.15
Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol (2006) 2.14
Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection. J Exp Med (2004) 2.05
Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol (2007) 2.04
Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet (2005) 2.03
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (2012) 2.01
Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells (2009) 2.01
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A (2011) 1.98
Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression. Blood (2007) 1.93
Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev (2008) 1.88
Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J Exp Med (2003) 1.87
Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med (2010) 1.86
Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology (2005) 1.81
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2012) 1.80
Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept. Arthritis Rheum (2007) 1.80
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest (2003) 1.77
Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol (2004) 1.71
T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med (2002) 1.69
The genetics of inflammatory bowel disease. Gastroenterology (2007) 1.66
TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia. Cancer Res (2007) 1.66
Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis. J Leukoc Biol (2012) 1.65
Emergence of the Th17 pathway and its role in host defense. Adv Immunol (2008) 1.65
Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J Immunol (2007) 1.58
Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am J Physiol Lung Cell Mol Physiol (2008) 1.58
The Th17 family: flexibility follows function. Immunol Rev (2013) 1.58
Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect Immun (2011) 1.58
Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis. Am J Pathol (2009) 1.56
Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53
Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial. J Infect Dis (2010) 1.51
Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol (2002) 1.49
TGF-beta: receptors, signaling pathways and autoimmunity. Curr Dir Autoimmun (2002) 1.48
IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol (2013) 1.45
Dynamic regulation of T cell immunity by CD43. J Immunol (2002) 1.45
The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes. Proc Natl Acad Sci U S A (2008) 1.44
Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J Immunol (2002) 1.44
Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol (2011) 1.40
Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis (2007) 1.40
Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A (2012) 1.40
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J Immunol (2011) 1.39
The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection. J Immunol (2004) 1.37
Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. J Virol (2005) 1.37
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci U S A (2013) 1.37