Published in Neurocrit Care on October 01, 2013
Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury. Brain Behav Immun (2014) 0.95
Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma (2015) 0.79
NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS (2017) 0.75
Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury. J Neurotrauma (2017) 0.75
A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80
Assessment of outcome after severe brain damage. Lancet (1975) 27.39
A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science (2006) 15.18
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A (2000) 5.89
Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain. J Clin Epidemiol (2001) 4.20
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med (2003) 3.37
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol (2005) 3.34
Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci (2005) 3.19
ABC transporters and the blood-brain barrier. Curr Pharm Des (2004) 1.92
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta (2009) 1.79
Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet (2006) 1.66
The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics (2001) 1.50
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett (2005) 1.38
Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain (2011) 1.33
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenet Genomics (2011) 1.29
Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. Br J Clin Pharmacol (2005) 1.12
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia. Nat Neurosci (2006) 1.10
P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb Exp Pharmacol (2011) 1.10
Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genomics (2009) 1.02
Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia (2008) 1.01
Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese. Epilepsy Behav (2007) 1.01
A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. Pharmacogenet Genomics (2010) 1.01
ABC transporters in the CNS - an inventory. Curr Pharm Biotechnol (2011) 1.00
Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem (2001) 0.99
ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain (2009) 0.99
Genetic association studies in patients with traumatic brain injury. Neurosurg Focus (2010) 0.99
Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study. Ther Drug Monit (2007) 0.98
Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses. Pharmacogenomics (2007) 0.91
Genetic factors in outcome after traumatic brain injury: what the human genome project can teach us about brain trauma. J Head Trauma Rehabil (2006) 0.91
The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy. Seizure (2008) 0.90
Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Respir Res (2010) 0.85
Targeting CNS transporters for treatment of neurodegenerative diseases. Curr Pharm Des (2014) 0.85
Genetic factors influencing outcome from neurotrauma. Curr Opin Psychiatry (2012) 0.84
Association of ABCB1 gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis. Pharmacogenomics (2011) 0.84
ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts. Pharmacogenet Genomics (2009) 0.84
Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition. Expert Opin Drug Deliv (2006) 0.82
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system. Pediatrics (2005) 15.40
Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol (2010) 5.23
Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet (2005) 4.91
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Clinical trials in head injury. J Neurotrauma (2002) 4.34
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet (2009) 4.22
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem (2004) 3.06
Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med (2011) 3.05
Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med (2009) 2.81
In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Crit Care Med (2009) 2.70
IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study. Epilepsia (2014) 2.59
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet (2004) 2.58
Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions. J Pediatr (2007) 2.42
Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. Lancet Neurol (2011) 2.40
Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet (2005) 2.34
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. J Neurosci (2007) 2.23
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol (2005) 2.17
Neurostimulation for traumatic brain injury. J Neurosurg (2014) 2.10
Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg (2013) 2.05
Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury. Crit Care Med (2014) 2.04
Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem (2003) 2.04
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med (2009) 2.00
Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg (2005) 1.99
Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic. Pediatr Crit Care Med (2010) 1.95
A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest. Pediatr Crit Care Med (2010) 1.90
Occipital condyle fractures: clinical decision rule and surgical management. J Neurosurg Spine (2009) 1.85
Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation (2006) 1.84
Neurological injury markers in children with septic shock. Pediatr Crit Care Med (2008) 1.71
Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury. J Neurotrauma (2011) 1.71
Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med (2009) 1.70
Guideline Adherence and Hospital Costs in Pediatric Severe Traumatic Brain Injury. Pediatr Crit Care Med (2016) 1.69
Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock. Pediatr Crit Care Med (2004) 1.69
Long-term outcomes and prognostic factors in pediatric patients with severe traumatic brain injury and elevated intracranial pressure. J Neurosurg Pediatr (2008) 1.69
Urinary S100B concentrations are increased after brain injury in children: A preliminary study. Pediatr Crit Care Med (2006) 1.68
Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats. Crit Care Med (2003) 1.68
Complications and radiographic correction in adult scoliosis following combined transpsoas extreme lateral interbody fusion and posterior pedicle screw instrumentation. Neurosurg Focus (2010) 1.65
Intracranial pressure-monitoring systems in children with traumatic brain injury: combining therapeutic and diagnostic tools. Pediatr Crit Care Med (2011) 1.65
Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs. Crit Care Med (2004) 1.62
Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology (2009) 1.61
Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury. J Neurotrauma (2009) 1.60
Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model. Crit Care Med (2006) 1.59
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nat Neurosci (2012) 1.58
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. Crit Care Med (2012) 1.57
Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials. J Neurosurg (2012) 1.57
Extracorporeal versus conventional cardiopulmonary resuscitation after ventricular fibrillation cardiac arrest in rats: a feasibility trial. Crit Care Med (2013) 1.57
Brain injuries and neurological system failure are the most common proximate causes of death in children admitted to a pediatric intensive care unit. Pediatr Crit Care Med (2011) 1.56
Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Ann Neurol (2012) 1.55
Single-center experience with pediatric Cushing's disease. J Neurosurg (2005) 1.54
Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. Crit Care Med (2011) 1.54
Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med (2007) 1.53
Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem (2002) 1.52
Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia. Crit Care Med (2003) 1.52
Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest*. Crit Care Med (2014) 1.52
Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques. Neurosurg Focus (2014) 1.51
Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit Care Med (2013) 1.51
Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. J Neurotrauma (2013) 1.51
Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. Crit Care Med (2009) 1.49
Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury. Crit Care (2004) 1.49
Starving neurons show sex difference in autophagy. J Biol Chem (2008) 1.49
Dysautonomia after pediatric brain injury. Dev Med Child Neurol (2012) 1.49
Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs. Crit Care Med (2010) 1.48
National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery (2013) 1.48
Comparative effectiveness of using computed tomography alone to exclude cervical spine injuries in obtunded or intubated patients: meta-analysis of 14,327 patients with blunt trauma. J Neurosurg (2011) 1.47
Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. J Cereb Blood Flow Metab (2003) 1.46
Winning the cold war: inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Crit Care Med (2007) 1.46
Therapeutic hypothermia after cardiac arrest. N Engl J Med (2002) 1.46
Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial. Crit Care Med (2007) 1.46
High-definition fiber tracking for assessment of neurological deficit in a case of traumatic brain injury: finding, visualizing, and interpreting small sites of damage. J Neurosurg (2012) 1.45
Brain tissue oxygen monitoring after severe traumatic brain injury in children: relationship to outcome and association with other clinical parameters. J Neurosurg Pediatr (2012) 1.45
Validity of a pediatric version of the Glasgow Outcome Scale-Extended. J Neurotrauma (2012) 1.45