Published in Am J Hum Genet on May 27, 2004
GARM II: A Study on the Genetics of Age-related Maculopathy | NCT01115387
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet (2005) 4.91
The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol (2006) 3.60
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19
Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med (2006) 2.99
Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet (2006) 2.89
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40
An update on the genetics of age-related macular degeneration. Mol Vis (2007) 1.95
No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. Hum Genet (2006) 1.54
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. Invest Ophthalmol Vis Sci (2008) 1.28
C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PLoS One (2008) 1.22
The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2007) 1.17
Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol (2011) 1.16
Genetics. Was the Human Genome Project worth the effort? Science (2005) 1.16
Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet (2009) 1.16
Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics. Mol Aspects Med (2012) 1.16
Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. J Ocul Biol Dis Infor (2009) 1.13
The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology (2008) 1.07
Genetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease management. Ophthalmology (2012) 1.07
Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. Invest Ophthalmol Vis Sci (2009) 1.07
Lipids, lipoproteins, and age-related macular degeneration. J Lipids (2011) 1.05
Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. Hum Genet (2010) 1.04
Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm (2012) 1.04
Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med (2012) 1.03
Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol (2013) 1.01
Age-related macular degeneration-clinical review and genetics update. Clin Genet (2013) 1.00
Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis (2008) 0.90
Genetic and functional dissection of ARMS2 in age-related macular degeneration and polypoidal choroidal vasculopathy. PLoS One (2013) 0.90
Genetic loci that control the size of laser-induced choroidal neovascularization. FASEB J (2009) 0.89
Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report. J Transl Med (2013) 0.89
Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. Eur J Clin Pharmacol (2008) 0.86
The impact of the human genome project on complex disease. Genes (Basel) (2014) 0.85
Dark matters in AMD genetics: epigenetics and stochasticity. Invest Ophthalmol Vis Sci (2011) 0.84
Age-related macular degeneration. Ulster Med J (2005) 0.84
Ordered-subset analysis (OSA) for family-based association mapping of complex traits. Genet Epidemiol (2008) 0.84
Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration. BMC Res Notes (2010) 0.83
Complement factor H: using atomic resolution structure to illuminate disease mechanisms. Adv Exp Med Biol (2008) 0.79
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review. J Clin Med (2016) 0.79
AMD and the alternative complement pathway: genetics and functional implications. Hum Genomics (2016) 0.78
Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy. Expert Rev Ophthalmol (2013) 0.77
A novel ARMS2 splice variant is identified in human retina. Exp Eye Res (2011) 0.77
[Y402H polymorphism in complement factor H and age-related macula degeneration (AMD)]. Ophthalmologe (2005) 0.77
Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration. Cold Spring Harb Perspect Med (2014) 0.76
A composite-likelihood approach for identifying polymorphisms that are potentially directly associated with disease. Eur J Hum Genet (2008) 0.76
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration. Biochim Biophys Acta (2016) 0.76
Gene ontology and KEGG enrichment analyses of genes related to age-related macular degeneration. Biomed Res Int (2014) 0.75
Expression of recombinant protein encoded by LOC387715 in Escherichia coli. Protein Expr Purif (2007) 0.75
The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment. Mol Immunol (2016) 0.75
Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan. Sci Rep (2017) 0.75
Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. Int Ophthalmol (2016) 0.75
Genetic risk models: Influence of model size on risk estimates and precision. Genet Epidemiol (2017) 0.75
A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80
PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet (1998) 23.25
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol (2001) 21.37
Allegro, a new computer program for multipoint linkage analysis. Nat Genet (2000) 14.00
Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet (1997) 13.93
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet (1994) 7.07
Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet (2000) 6.96
A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA (1996) 3.79
A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet (1999) 3.32
Strategies for characterizing highly polymorphic markers in human gene mapping. Am J Hum Genet (1992) 3.25
A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet (2003) 3.23
The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity. Am J Hum Genet (1983) 3.23
Age-related macular degeneration--a genome scan in extended families. Am J Hum Genet (2003) 2.99
Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet (2004) 2.97
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet (1998) 2.82
Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol (1996) 2.80
Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genet (2003) 2.72
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet (2000) 2.50
The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking. Am J Epidemiol (1993) 2.37
Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters. Am J Hum Genet (2000) 2.35
Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol (1998) 2.19
APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. Nat Genet (1998) 2.05
Genetic linkage analysis of complex genetic traits by using affected sibling pairs. Biometrics (1998) 2.04
The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol (1998) 2.04
A full genome scan for age-related maculopathy. Hum Mol Genet (2000) 1.96
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A (1999) 1.91
Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions. Am J Ophthalmol (2001) 1.88
Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration. Nat Genet (1998) 1.80
Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l'Age. Arch Ophthalmol (1998) 1.67
Molecular genetics of age-related macular degeneration. Hum Mol Genet (2001) 1.55
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet (2002) 1.49
Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. Mol Vis (2004) 1.35
Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs. Ann Hum Genet (2001) 1.29
Estimation of allele frequencies with data on sibships. Genet Epidemiol (2001) 1.24
Smoking and neovascular form of age related macular degeneration in late middle aged males: findings from a case-control study in Japan. Research Committee on Chorioretinal Degenerations. Br J Ophthalmol (1997) 1.02
The burden of age-related macular degeneration: results of a cohort study in two French referral centres. Pharmacoeconomics (2003) 1.00
Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration. Arch Ophthalmol (2003) 0.99
New treatments in age-related macular degeneration. Clin Experiment Ophthalmol (2003) 0.99
Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer Dis Assoc Disord (1998) 0.99
Smoking is also associated with age-related macular degeneration in persons aged 85 years and older: The Rotterdam Study. Arch Ophthalmol (1997) 0.96
The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. Ophthalmologica (2000) 0.91
Identifying the proportion of age related macular degeneration patients who would benefit from photodynamic therapy with verteporfin (Visudyne). Br J Ophthalmol (2002) 0.87
Application of an ordered subset analysis approach to the genetics of alcoholism. Genet Epidemiol (1999) 0.87
The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking. Surv Ophthalmol (1994) 0.83
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44
An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol (2007) 8.12
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet (2004) 7.45
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science (2005) 7.03
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Ophthalmol (2009) 5.41
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet (2003) 5.34
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet (2005) 4.91
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85
No gene is an island: the flip-flop phenomenon. Am J Hum Genet (2007) 4.69
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes (2005) 4.31
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. PLoS Genet (2009) 4.22
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J (2002) 3.99
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Prevention and treatment of common eye injuries in sports. Am Fam Physician (2003) 3.63
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet (2009) 3.54
Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research. Am J Public Health (2005) 3.50
Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina (2006) 3.48
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology (2005) 3.48
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet (2003) 3.39
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35
Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet (2004) 3.35
Pharmacotherapy for neovascular age-related macular degeneration: an analysis of the 100% 2008 medicare fee-for-service part B claims file. Am J Ophthalmol (2011) 3.24
Population stratification confounds genetic association studies among Latinos. Hum Genet (2005) 3.19
Avastin doesn't blind people, people blind people. Am J Ophthalmol (2012) 3.15
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet (2006) 3.13
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am J Hum Genet (2002) 2.98
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Endophthalmitis after intravitreal vascular [corrected] endothelial growth factor antagonists: a six-year experience at a university referral center. Retina (2011) 2.97
Acute zonal occult outer retinopathy: a long-term follow-up study. Am J Ophthalmol (2002) 2.92
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet (2002) 2.90
Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet (2006) 2.89
Racial differences in the relation between uncoupling protein genes and resting energy expenditure. Am J Clin Nutr (2002) 2.84
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. Nat Genet (2005) 2.79
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol (2006) 2.77
Antipsychotic treatment and the risk of hip fracture in subjects with schizophrenia: a 10-year population-based case-control study. J Clin Psychiatry (2015) 2.73
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet (2003) 2.71
Genomic screen and follow-up analysis for autistic disorder. Am J Med Genet (2002) 2.70
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. Am J Hum Genet (2010) 2.64