Published in Fluids Barriers CNS on May 01, 2017
Blood-brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow. Fluids Barriers CNS (2017) 0.75
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology (2001) 6.30
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 5.14
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80
Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev (2012) 2.98
Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther (2011) 2.61
Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res (2012) 2.60
microRNA-34c is a novel target to treat dementias. EMBO J (2011) 2.44
Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost (2007) 2.34
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol (2012) 2.33
Explosive blast neurotrauma. J Neurotrauma (2009) 2.23
Blood-brain barrier breakdown in the aging human hippocampus. Neuron (2015) 2.17
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med (2007) 2.16
Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol (2011) 2.14
Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected]. Proc Natl Acad Sci U S A (2010) 2.05
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci Transl Med (2013) 1.99
A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med (2012) 1.85
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun (2012) 1.82
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods (2015) 1.82
Coagulopathy after traumatic brain injury. Neurosurgery (2012) 1.78
Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement (2014) 1.56
Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle. J Control Release (2013) 1.46
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab (2013) 1.45
Blood-brain barrier pathophysiology in traumatic brain injury. Transl Stroke Res (2011) 1.45
A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Sci Rep (2014) 1.38
United Atom Lipid Parameters for Combination with the Optimized Potentials for Liquid Simulations All-Atom Force Field. J Chem Theory Comput (2009) 1.37
Blood-brain barrier disruption and intra-arterial methotrexate-based therapy for newly diagnosed primary CNS lymphoma: a multi-institutional experience. J Clin Oncol (2009) 1.35
Microfluidics and coagulation biology. Annu Rev Biomed Eng (2013) 1.30
Establishment and Dysfunction of the Blood-Brain Barrier. Cell (2015) 1.30
Differential fates of biomolecules delivered to target cells via extracellular vesicles. Proc Natl Acad Sci U S A (2015) 1.27
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol (2014) 1.27
Insulin in the brain: there and back again. Pharmacol Ther (2012) 1.25
Wartime traumatic cerebral vasospasm: recent review of combat casualties. Neurosurgery (2006) 1.25
IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol (2013) 1.24
Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology (2015) 1.20
Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J (2014) 1.20
Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma (2008) 1.17
Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res (2011) 1.16
Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release. ACS Nano (2012) 1.12
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Genes Dev (2015) 1.08
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One (2014) 1.07
Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia (2013) 1.05
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. J Control Release (2014) 1.03
The blood-brain barrier in neuroimmunology: Tales of separation and assimilation. Brain Behav Immun (2014) 1.03
Monte Carlo vs molecular dynamics for all-atom polypeptide folding simulations. J Phys Chem B (2006) 1.01
Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS One (2013) 1.00
New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution. Mol Cancer Ther (2006) 1.00
Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. J Neurotrauma (2014) 1.00
Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun (2015) 0.98
CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy. Mol Cancer Ther (2009) 0.97
Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury. JAMA Neurol (2016) 0.97
Enzyme improvement in the absence of structural knowledge: a novel statistical approach. ISME J (2007) 0.96
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. J Cereb Blood Flow Metab (2014) 0.95
Transport physics and biorheology in the setting of hemostasis and thrombosis. J Thromb Haemost (2016) 0.95
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Biomicrofluidics (2015) 0.94
Brain-penetrating nanoparticles improve paclitaxel efficacy in malignant glioma following local administration. ACS Nano (2014) 0.93
Peptide Partitioning and Folding into Lipid Bilayers. J Chem Theory Comput (2009) 0.93
Effect of N-acetylcysteine route of administration on chemoprotection against cisplatin-induced toxicity in rat models. Cancer Chemother Pharmacol (2007) 0.92
Passage of peptides across the blood-brain barrier: pathophysiological perspectives. Life Sci (1996) 0.92
Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury. J Neurotrauma (2015) 0.92
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia. J Cereb Blood Flow Metab (2015) 0.92
Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells. Fluids Barriers CNS (2015) 0.92
From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov (2016) 0.92
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Mol Ther Nucleic Acids (2015) 0.91
Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma. Front Mol Neurosci (2014) 0.90
Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival. Oncoimmunology (2015) 0.90
A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles. Adv Pharm Bull (2015) 0.89
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances. Adv Pharmacol (2014) 0.88
Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery. J Control Release (2013) 0.88
Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol (2014) 0.87
Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury. Front Neurol (2015) 0.85
Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype. PLoS One (2016) 0.85
Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain. Adv Healthc Mater (2015) 0.85
Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury. J Neurotrauma (2014) 0.85
Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival. CNS Oncol (2014) 0.84
MRI virtual biopsy and treatment of brain metastatic tumors with targeted nanobioconjugates: nanoclinic in the brain. ACS Nano (2015) 0.82
Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle. Cancer Res (2015) 0.82
Spherical nucleic acids for precision medicine. Oncotarget (2014) 0.81
Microparticles impact coagulation after traumatic brain injury. J Surg Res (2015) 0.80
What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev Neurother (2014) 0.79
Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix. Biomaterials (2014) 0.79
On-command drug release from nanochains inhibits growth of breast tumors. Pharm Res (2013) 0.79
Review: in vitro microvessel models. Lab Chip (2015) 0.79
Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma (2015) 0.79
Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine. Xenobiotica (2016) 0.78
Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats. J Neurotrauma (2015) 0.78
Cerebral hemodynamic changes after wartime traumatic brain injury. Acta Neurochir Suppl (2013) 0.78
Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods (2015) 0.78
Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration. Curr Pharm Des (2014) 0.78
Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm (2016) 0.78
Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury. Neurocrit Care (2013) 0.77
Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma. J Mater Chem B Mater Biol Med (2014) 0.77
HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug. Nanomedicine (2016) 0.76
Nose to Brain Delivery of Nanoformulations for Neurotherapeutics in Parkinson`s disease: Defining the Preclinical, Clinical and toxicity issues. Curr Drug Deliv (2016) 0.76
Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology. J Trauma Acute Care Surg (2016) 0.76
Systems Analysis of Thrombus Formation. Circ Res (2016) 0.76
Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug. BMC Cancer (2016) 0.76