Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3779710)

Published in J Biol Chem on July 30, 2013

Authors

Michelle A Lum1, Gregor M Balaburski, Maureen E Murphy, Adrian R Black, Jennifer D Black

Author Affiliations

1: From The Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950.

Articles cited by this

Methods in mammalian autophagy research. Cell (2010) 20.08

HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98

The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J (2008) 4.79

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett (2007) 4.23

Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol (1995) 2.83

Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81

Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukoc Biol (2006) 2.79

17AAG: low target binding affinity and potent cell activity--finding an explanation. Mol Cancer Ther (2003) 2.74

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J Biol Chem (2000) 2.66

A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63

The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem (2007) 2.24

Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol (1998) 2.15

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem (2009) 1.97

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell (2009) 1.96

Physiological regulation of Akt activity and stability. Am J Transl Res (2010) 1.95

PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab (2008) 1.92

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem (2005) 1.85

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem (2012) 1.85

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol (2008) 1.80

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol (2009) 1.72

ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem (2003) 1.70

PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol Sci (2007) 1.62

Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha. Curr Biol (1996) 1.59

Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. J Biol Chem (1997) 1.56

The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem (2002) 1.52

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50

Physiological mechanisms of signal termination in biological systems. Acta Physiol (Oxf) (2012) 1.49

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47

The life and death of protein kinase C. Curr Drug Targets (2008) 1.46

Hsp70 and its molecular role in nervous system diseases. Biochem Res Int (2011) 1.44

Heat shock protein 90 in neurodegenerative diseases. Mol Neurodegener (2010) 1.38

Negative Regulation of AKT Activation by BRCA1. Cancer Res (2008) 1.34

Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes. Biochem J (1999) 1.32

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. J Biol Chem (1994) 1.27

12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer. J Biol Chem (1996) 1.27

Threonine-497 is a critical site for permissive activation of protein kinase C alpha. Biochem J (1994) 1.26

Studies on the phosphorylation of protein kinase C-alpha. Biochem J (1992) 1.22

Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells. J Biol Chem (2003) 1.22

Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem (2009) 1.22

Death by chaperone: HSP90, HSP70 or both? Cell Cycle (2009) 1.22

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res (2011) 1.21

Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment. J Cell Sci (2000) 1.20

Ubiquitination of protein kinase C-alpha and degradation by the proteasome. J Biol Chem (1996) 1.19

Biosynthesis and posttranslational modifications of protein kinase C in human breast cancer cells. J Biol Chem (1989) 1.15

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. J Biol Chem (1993) 1.14

A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res (2013) 1.14

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med (2011) 1.11

Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism. Mol Cell Biol (2010) 1.09

Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells. J Biol Chem (1994) 1.09

Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts. Mol Pharmacol (1997) 1.09

Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes. J Biol Chem (2007) 1.07

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex. Biochem Biophys Res Commun (2006) 1.07

An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem (1998) 1.06

Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci (2007) 1.06

Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem (1998) 1.05

Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides. FEBS Lett (2002) 1.04

Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry (2009) 1.01

Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta. Biochem J (2002) 0.98

Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem (2006) 0.98

Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem (2011) 0.96

Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin. Am J Physiol (1996) 0.95

Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 Reservoirs. Adv Virol (2012) 0.94

Protein kinase C (PKC)-induced PKC degradation: a model for down-regulation. Biochem Soc Trans (1995) 0.93

Liposome-based DNA carriers may induce cellular stress response and change gene expression pattern in transfected cells. BMC Mol Biol (2011) 0.91

Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane. Eur J Biochem (1996) 0.90

Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. Proc Natl Acad Sci U S A (1998) 0.89

Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89

Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. Cell Signal (2011) 0.87

Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem (2012) 0.87

Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression. Cell Mol Life Sci (2010) 0.87

Expression, subcellular distribution and response to phorbol esters of protein kinase C (PKC) isozymes in drug-sensitive and multidrug-resistant KB cells evidence for altered regulation of PKC-alpha. Eur J Biochem (1996) 0.86

Protein kinase C isozymes in colon carcinogenesis: guilt by omission. Gastroenterology (2001) 0.86

Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP. Am J Physiol Renal Physiol (2010) 0.86

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res (2009) 0.86

New and emerging treatments for Alzheimer's disease. Expert Rev Neurother (2012) 0.84

Down-regulating protein kinase C alpha: functional cooperation between the proteasome and the endocytic system. Cell Signal (2009) 0.83

Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ. Med Res Rev (2010) 0.83

Cisplatin resistance is associated with deregulation in protein kinase C-delta. Biochem Biophys Res Commun (2004) 0.82

Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism. J Biol Chem (2013) 0.81

Impaired degradation of PKCalpha by proteasome in a cellular model of Huntington's disease. Neuroreport (2003) 0.81

Proteasome implication in phorbol ester- and GnRH-induced selective down-regulation of PKC (alpha, epsilon, zeta) in alpha T(3)-1 and L beta T(2) gonadotrope cell lines. Endocrinology (2002) 0.80

Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2006) 0.80

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases. Cell Cycle (2012) 0.79

Lifespan regulation of conventional protein kinase C isotypes. Biochem Soc Trans (2007) 0.78

Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells. Cancer Lett (1991) 0.78

The biology and physiology of the heat shock and glucose-regulated stress protein systems. Methods Achiev Exp Pathol (1991) 0.76

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol (2004) 5.56

A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63

A physician responds. J Am Dent Assoc (2002) 2.02

BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol (2002) 1.84

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79

Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem (2008) 1.55

Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem (2004) 1.53

Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer Biol Ther (2011) 1.49

ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45

Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. Ann Surg Oncol (2006) 1.39

Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. J Biol Chem (2007) 1.26

The ARF tumor suppressor can promote the progression of some tumors. Cancer Res (2008) 1.24

Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells. J Biol Chem (2003) 1.22

HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res (2011) 1.21

The codon 47 polymorphism in p53 is functionally significant. J Biol Chem (2005) 1.20

The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol (2011) 1.20

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem (2009) 1.17

A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Clin Cancer Res (2007) 1.14

A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res (2013) 1.14

Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC Womens Health (2005) 1.12

The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biol Ther (2007) 1.09

p53 and ARF: unexpected players in autophagy. Trends Cell Biol (2010) 1.08

Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08

Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma. J Gastrointest Surg (2004) 1.08

Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response. J Biol Chem (2012) 1.07

SUMO-1 modification of human cytomegalovirus IE1/IE72. J Virol (2002) 1.03

Akt expression may predict favorable prognosis in cholangiocarcinoma. J Gastroenterol Hepatol (2006) 1.02

Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line. Cancer Biol Ther (2003) 1.02

Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin. J Biol Chem (2007) 1.01

Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells. J Biol Chem (2003) 1.01

Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle (2011) 0.93

Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. J Biol Chem (2006) 0.93

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance. Mol Cell Biol (2004) 0.93

Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro. PLoS One (2012) 0.93

Protein kinase C signaling and cell cycle regulation. Front Immunol (2013) 0.92

Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem Biol (2014) 0.92

The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle (2007) 0.92

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res (2014) 0.89

The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. Biochem Pharmacol (2006) 0.87

Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell Cycle (2011) 0.86

Temporal and spatial expression of TACC1 in the mouse and human. Dev Dyn (2006) 0.86

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res (2009) 0.86

ARF, autophagy and tumor suppression. Autophagy (2009) 0.85

Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol (2014) 0.84

Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism. J Biol Chem (2013) 0.81

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest. PLoS One (2013) 0.81

Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function. Cancer Biol Ther (2011) 0.81

Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J Biol Chem (2011) 0.80

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver. J Liver (2013) 0.79

Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics. Curr Med Chem (2016) 0.78

Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis. Cancer Biol Ther (2008) 0.78

Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-ortho-phenylacetate in intestinal epithelial cells. Biochem Pharmacol (2004) 0.77

p53, transcriptional, and drug sensitivity: fresh perspectives on an old activity. Cell Cycle (2010) 0.75

Healthcare in eastern North Carolina. N C Med J (2002) 0.75

Methods to study p53-repressed promoters. Methods Mol Biol (2003) 0.75

Autophagy researchers. Autophagy (2014) 0.75

Differential display techniques to identify tumor suppressor gene pathways. Methods Mol Biol (2003) 0.75