Published in Mol Cell on October 09, 2009
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40
Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem (2010) 2.21
The HSP70 family and cancer. Carcinogenesis (2013) 2.06
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol (2010) 1.71
A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol Cell (2013) 1.65
Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther (2011) 1.55
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med (2013) 1.36
Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol (2010) 1.34
Killing a cancer: what are the alternatives? Nat Rev Cancer (2012) 1.30
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem (2010) 1.29
A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell (2012) 1.26
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A (2013) 1.24
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res (2011) 1.21
Autophagy modulation for cancer therapy. Cancer Biol Ther (2011) 1.20
A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas. Clin Cancer Res (2011) 1.20
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med (2012) 1.18
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ (2011) 1.18
Retracted Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. J Biol Chem (2013) 1.16
The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood (2012) 1.15
A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res (2013) 1.14
Functional analysis of Hsp70 inhibitors. PLoS One (2013) 1.13
Selective targeting of the stress chaperome as a therapeutic strategy. Trends Pharmacol Sci (2014) 1.12
HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein. J Biol Chem (2012) 1.12
p53 and ARF: unexpected players in autophagy. Trends Cell Biol (2010) 1.08
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res (2014) 1.06
Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge. PLoS One (2012) 1.06
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line. J Assoc Res Otolaryngol (2013) 1.05
Hsp70 in cancer: back to the future. Oncogene (2014) 1.03
Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A (2013) 1.01
Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci (2013) 1.00
Novel Insights into the Interplay between Apoptosis and Autophagy. Int J Cell Biol (2012) 1.00
Evaluating melanoma drug response and therapeutic escape with quantitative proteomics. Mol Cell Proteomics (2014) 1.00
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One (2012) 0.98
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol (2015) 0.98
The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol (2015) 0.98
p53 and mitochondrial function in neurons. Biochim Biophys Acta (2014) 0.97
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. J Med Chem (2014) 0.97
Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia. Blood Cancer J (2011) 0.96
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma. Cell Death Dis (2013) 0.96
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association? Genes Cancer (2010) 0.96
The human HSP70 family of chaperones: where do we stand? Cell Stress Chaperones (2016) 0.95
BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem (2011) 0.95
Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One (2011) 0.94
Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. Proc Natl Acad Sci U S A (2013) 0.94
2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice. PLoS One (2013) 0.92
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol (2016) 0.92
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem Biol (2014) 0.92
OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death Dis (2013) 0.92
Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. Cell Chem Biol (2016) 0.92
HSP70 natively and specifically associates with an N-terminal dermcidin-derived peptide that contains an HLA-A*03 antigenic epitope. J Biol Chem (2011) 0.90
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. PLoS One (2014) 0.90
Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther (2015) 0.90
Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code. Biochim Biophys Acta (2013) 0.90
Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89
Non-muscle myosin IIA transports a Golgi glycosyltransferase to the endoplasmic reticulum by binding to its cytoplasmic tail. Int J Biochem Cell Biol (2012) 0.89
Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer. Oncol Rep (2014) 0.89
Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements. Mol Cell Biol (2012) 0.89
Differential roles of Hsp70 and Hsp90 in the assembly of the replicase complex of a positive-strand RNA plant virus. J Virol (2012) 0.89
Nonclassical antigen-processing pathways are required for MHC class II-restricted direct tumor recognition by NY-ESO-1-specific CD4(+) T cells. Cancer Immunol Res (2013) 0.89
Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chem Biol (2014) 0.88
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein. Oncogene (2015) 0.88
Mutation in integrin-linked kinase (ILK(R211A)) and heat-shock protein 70 comprise a broadly cardioprotective complex. PLoS One (2013) 0.88
A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. J Biol Chem (2014) 0.88
Pifithrin-μ, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells. PLoS One (2013) 0.87
Protein chaperones: a composition of matter review (2008 - 2013). Expert Opin Ther Pat (2014) 0.86
Re-evaluating PARP1 inhibitor in cancer. Nat Biotechnol (2011) 0.86
The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels. Dis Model Mech (2014) 0.86
Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses. J Biomed Sci (2012) 0.86
ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther (2015) 0.85
A comparative study of stress-mediated immunological functions with the adjuvanticity of alum. J Biol Chem (2012) 0.85
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry (2011) 0.85
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. J Biol Chem (2011) 0.85
Drugging the addict: non-oncogene addiction as a target for cancer therapy. EMBO Rep (2016) 0.84
A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition. Biochim Biophys Acta (2014) 0.84
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity. Oncogene (2014) 0.83
Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells. Mol Cancer (2012) 0.83
Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma. Curr Pharm Des (2013) 0.83
Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ. Pain (2015) 0.83
Drug resistance in natural isolates of Leishmania donovani s.l. promastigotes is dependent of Pgp170 expression. PLoS One (2013) 0.83
Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. ACS Chem Biol (2012) 0.83
Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A (2015) 0.82
Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells. PLoS One (2013) 0.82
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition. Cancer Biol Ther (2013) 0.81
Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells. Int J Mol Sci (2013) 0.81
Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function. Cancer Biol Ther (2011) 0.81
Protease addiction and synthetic lethality in cancer. Front Oncol (2011) 0.81
Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy. Expert Rev Proteomics (2010) 0.81
Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. Antimicrob Agents Chemother (2015) 0.81
Etoposide induces cell death via mitochondrial-dependent actions of p53. Cancer Cell Int (2015) 0.80
HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats. Histochem Cell Biol (2010) 0.80
Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones. J Biol Chem (2016) 0.80
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci (2015) 0.79
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions. PLoS One (2014) 0.79
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95
Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci (2005) 9.75
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet (2003) 6.46
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci (2005) 5.00
Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol (2009) 4.74
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell (2008) 4.48
The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett (2007) 4.23
Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20
Maturation of autophagic vacuoles in Mammalian cells. Autophagy (2005) 4.08
Signal integration and diversification through the p62 scaffold protein. Trends Biochem Sci (2006) 3.50
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol (2008) 3.36
Hsp70 and Hsp90--a relay team for protein folding. Rev Physiol Biochem Pharmacol (2004) 3.29
Does autophagy contribute to cell death? Autophagy (2005) 3.21
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21
Non-oncogene addiction and the stress phenotype of cancer cells. Cell (2007) 3.19
Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol (2000) 3.05
CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones (2003) 2.98
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med (2004) 2.86
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest (2008) 2.83
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med (2006) 2.67
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev (2005) 2.67
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell (2008) 2.49
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol (2006) 2.47
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol (2008) 2.33
Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett (2007) 2.21
Protein quality control: chaperones culling corrupt conformations. Nat Cell Biol (2005) 2.20
Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry (2008) 2.18
Delta dnaK52 mutants of Escherichia coli have defects in chromosome segregation and plasmid maintenance at normal growth temperatures. J Bacteriol (1989) 1.96
Methods for assessing autophagy and autophagic cell death. Methods Mol Biol (2008) 1.96
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res (2007) 1.87
Mechanisms for regulation of Hsp70 function by Hsp40. Cell Stress Chaperones (2003) 1.84
Methods to monitor chaperone-mediated autophagy. Methods Enzymol (2009) 1.78
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr Top Med Chem (2006) 1.77
The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J Cell Sci (2008) 1.67
The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci (2008) 1.63
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. J Biomed Biotechnol (2006) 1.44
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell (2008) 1.44
Heat shock protein 70 is required for the survival of cancer cells. Ann N Y Acad Sci (2000) 1.44
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion. Cancer Res (2002) 1.40
Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev (2007) 1.37
DnaK mutants defective in ATPase activity are defective in negative regulation of the heat shock response: expression of mutant DnaK proteins results in filamentation. J Bacteriol (1994) 1.24
The ARF tumor suppressor can promote the progression of some tumors. Cancer Res (2008) 1.24
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. Cancer Res (2006) 1.24
Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination. FEBS Lett (2006) 1.19
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett (2008) 1.18
BAG-1: a multi-functional pro-survival molecule. Int J Biochem Cell Biol (2005) 1.14
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med (2008) 1.14
Identification of small molecules that modify the protein folding activity of heat shock protein 70. Anal Biochem (2007) 1.08
Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L. Int Rev Cytol (2004) 1.07
Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae. Genetics (2005) 1.05
Hsp70 chaperone as a survival factor in cell pathology. Int Rev Cytol (2006) 0.99
Evidence for p62 aggregate formation: role in cell survival. FEBS Lett (2005) 0.97
A Method to Identify p62's UBA Domain Interacting Proteins. Biol Proced Online (2003) 0.94
p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cell lines. Cancer Lett (1994) 0.93
Involvement of heat-shock protein 70 and P53 proteins in attenuation of UVC-induced apoptosis by thermal stress in hepatocellular carcinoma cells. Photochem Photobiol (1999) 0.84
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet (2003) 6.46
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol (2004) 5.56
A physician responds. J Am Dent Assoc (2002) 2.02
BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol (2002) 1.84
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem (2008) 1.55
Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer Biol Ther (2011) 1.49
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev (2007) 1.37
The ARF tumor suppressor can promote the progression of some tumors. Cancer Res (2008) 1.24
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Mol Cancer Res (2011) 1.21
The codon 47 polymorphism in p53 is functionally significant. J Biol Chem (2005) 1.20
The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol (2011) 1.20
Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem (2009) 1.17
p53 moves to mitochondria: a turn on the path to apoptosis. Cell Cycle (2004) 1.17
A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res (2013) 1.14
The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biol Ther (2007) 1.09
p53 and ARF: unexpected players in autophagy. Trends Cell Biol (2010) 1.08
Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08
Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line. Cancer Biol Ther (2003) 1.02
Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel (2009) 1.00
Tumor suppression by ARF: gatekeeper and caretaker. Cell Cycle (2010) 0.96
Methylseleninic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Oncogene (2005) 0.95
Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle (2011) 0.93
p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance. Mol Cell Biol (2004) 0.93
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem Biol (2014) 0.92
ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4. EMBO Rep (2009) 0.92
The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle (2007) 0.92
A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis. J Biol Chem (2009) 0.89
Historical biogeography of Drosophila simulans based on Y-chromosomal sequences. Mol Phylogenet Evol (2005) 0.89
Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell Melanoma Res (2014) 0.89
A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo. MAbs (2010) 0.88
The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. Biochem Pharmacol (2006) 0.87
ARF, autophagy and tumor suppression. Autophagy (2009) 0.85
Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem Biol (2014) 0.84
Genetic basis of sex-specific color pattern variation in Drosophila malerkotliana. Genetics (2008) 0.83
CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest. PLoS One (2013) 0.81
Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function. Cancer Biol Ther (2011) 0.81
The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver. J Liver (2013) 0.79
Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C. J Biol Chem (2013) 0.78
Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis. Cancer Biol Ther (2008) 0.78
p53, transcriptional, and drug sensitivity: fresh perspectives on an old activity. Cell Cycle (2010) 0.75
Autophagy researchers. Autophagy (2014) 0.75
Methods to study p53-repressed promoters. Methods Mol Biol (2003) 0.75
Differential display techniques to identify tumor suppressor gene pathways. Methods Mol Biol (2003) 0.75
Healthcare in eastern North Carolina. N C Med J (2002) 0.75