Published in Thyroid on October 16, 2013
Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77
Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci (2014) 0.92
Thyroid hormone analogues and derivatives: Actions in fatty liver. World J Hepatol (2014) 0.83
Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges. Curr Atheroscler Rep (2016) 0.81
Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro. Mol Cell Endocrinol (2014) 0.78
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res (2008) 2.76
Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. BMJ (2013) 2.74
Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Mol Cell Biol (2003) 2.19
A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A (2007) 1.97
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem (2002) 1.95
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov (2009) 1.92
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem (2007) 1.67
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem (2004) 1.66
Estimating changes in mean body temperature for humans during exercise using core and skin temperatures is inaccurate even with a correction factor. J Appl Physiol (1985) (2007) 1.62
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology (2012) 1.52
Structural basis for activation of fatty acid-binding protein 4. J Mol Biol (2007) 1.52
Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A (2011) 1.39
p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res (2002) 1.36
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem (2005) 1.32
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28
Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab (2004) 1.28
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27
Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004. J Gen Virol (2006) 1.25
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J Mol Biol (2006) 1.22
Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. J Steroid Biochem Mol Biol (2008) 1.19
Thyroxine-thyroid hormone receptor interactions. J Biol Chem (2004) 1.17
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. J Med Chem (2009) 1.17
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol (2007) 1.10
Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem (2005) 1.10
A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE (2006) 1.08
Thyroid hormone response element organization dictates the composition of active receptor. J Biol Chem (2007) 1.07
Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A (2011) 1.06
Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc Natl Acad Sci U S A (2009) 1.05
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem (2005) 1.03
Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M. J Cell Sci (2002) 1.02
Mode of peroxisome proliferator-activated receptor γ activation by luteolin. Mol Pharmacol (2012) 1.01
The Snellen human calorimeter revisited, re-engineered and upgraded: design and performance characteristics. Med Biol Eng Comput (2006) 1.00
A three-compartment thermometry model for the improved estimation of changes in body heat content. Am J Physiol Regul Integr Comp Physiol (2006) 0.99
Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology (2011) 0.99
Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors. Biophys J (2005) 0.98
Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: evidence of the likeliest escape pathway and its implications for the design of novel ligands. J Med Chem (2006) 0.98
Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry (2008) 0.98
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. PLoS One (2012) 0.97
Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes. BMC Med Genomics (2011) 0.97
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. Am J Physiol Endocrinol Metab (2013) 0.95
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology (2002) 0.93
Ligand dissociation from estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations. Mol Endocrinol (2008) 0.93
Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol (2005) 0.92
Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization. J Mol Biol (2013) 0.91
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem (2012) 0.90
A peroxisome proliferator-activated receptor gamma (PPARgamma)/PPARgamma coactivator 1beta autoregulatory loop in adipocyte mitochondrial function. J Biol Chem (2011) 0.90
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry (2013) 0.89
E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode. Proc Natl Acad Sci U S A (2005) 0.89
Negative regulation of superoxide dismutase-1 promoter by thyroid hormone. Mol Pharmacol (2006) 0.89
A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor. Nucl Recept (2004) 0.88
Metabolism: bile acids heat things up. Nature (2006) 0.87
Calorimetric measurement of postexercise net heat loss and residual body heat storage. Med Sci Sports Exerc (2008) 0.87
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol (2008) 0.87
Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes. Hepatology (2012) 0.87
Allosteric conversation in the androgen receptor ligand-binding domain surfaces. Mol Endocrinol (2012) 0.87
SATB1-mediated functional packaging of chromatin into loops. Methods (2012) 0.86
Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution. PLoS One (2012) 0.85
Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A (2010) 0.84
The interpretation of disease phenotypes to identify TSE strains following murine bioassay: characterisation of classical scrapie. Vet Res (2012) 0.84
A thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells. Stem Cells (2015) 0.83
Gene specific actions of thyroid hormone receptor subtypes. PLoS One (2013) 0.83
SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions. PLoS One (2013) 0.83
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding. PLoS One (2012) 0.83
Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding. Cell Biochem Biophys (2006) 0.82
Corepressor/coactivator paradox: potential constitutive coactivation by corepressor splice variants. Nucl Recept Signal (2006) 0.81
Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem (2003) 0.81
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC Struct Biol (2008) 0.81
Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron X-ray solution scattering. J Biol Chem (2003) 0.80
Low-resolution structures of thyroid hormone receptor dimers and tetramers in solution. Biochemistry (2007) 0.79
Heat balance and cumulative heat storage during intermittent bouts of exercise. Med Sci Sports Exerc (2009) 0.79
Identification of CCR4 and other essential thyroid hormone receptor co-activators by modified yeast synthetic genetic array analysis. Proc Natl Acad Sci U S A (2009) 0.79
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorg Med Chem (2012) 0.79
Towards selectively modulating mineralocorticoid receptor function: lessons from other systems. Mol Cell Endocrinol (2004) 0.79
Thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis. Ren Fail (2004) 0.78
Helix 12 dynamics and thyroid hormone receptor activity: experimental and molecular dynamics studies of Ile280 mutants. J Mol Biol (2011) 0.78
Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction. J Steroid Biochem Mol Biol (2012) 0.78
Molecular basis for dimer formation of TRbeta variant D355R. Proteins (2009) 0.78
Insulation disks on the skin to estimate muscle temperature. Eur J Appl Physiol (2006) 0.77
Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor. Eur J Pharm Sci (2013) 0.77
Improving the prediction of sweat losses during exercise. J Appl Physiol (1985) (2009) 0.77
FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. Pflugers Arch (2013) 0.77
A microfluidic, high throughput protein crystal growth method for microgravity. PLoS One (2013) 0.76
Estimating changes in volume-weighted mean body temperature using thermometry with an individualized correction factor. Am J Physiol Regul Integr Comp Physiol (2010) 0.76
Opening the black box: revealing the molecular basis of thyroid hormone transport. Endocrinology (2013) 0.75
Correction: Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer. PLoS One (2015) 0.75
The adenovirus 55 residue E1A protein is a transcriptional activator and binds the unliganded thyroid hormone receptor. J Gen Virol (2013) 0.75
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways. J Steroid Biochem Mol Biol (2009) 0.75
Development of 5N-Bicalutamide, A High-affinity Reversible Covalent Antiandrogen. ACS Chem Biol (2017) 0.75
Cardiovascular endocrinology: introduction. Endocr Rev (2003) 0.75
Mobility of the elastic counterpressure space suit glove. Aviat Space Environ Med (2009) 0.75
Compression under a mechanical counter pressure space suit glove. J Gravit Physiol (2002) 0.75
Skin microvascular flow during hypobaric exposure with and without a mechanical counter-pressure space suit glove. Aviat Space Environ Med (2002) 0.75