Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.

PubWeight™: 2.19‹?› | Rank: Top 2%

🔗 View Article (PMC 151696)

Published in Mol Cell Biol on March 01, 2003

Authors

Mahnaz Razandi1, Gordon Alton, Ali Pedram, Sanjiv Ghonshani, Paul Webb, Ellis R Levin

Author Affiliations

1: Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, California 90822, USA.

Articles citing this

Sex differences in drug abuse. Front Neuroendocrinol (2007) 4.01

Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol (2005) 3.44

Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev (2008) 3.13

Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest (2005) 2.89

Estrogen signaling multiple pathways to impact gene transcription. Curr Genomics (2006) 2.14

Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol Biol Cell (2004) 2.07

Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats. J Neurosci (2007) 1.88

Plasma membrane estrogen receptors. Trends Endocrinol Metab (2009) 1.85

Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell (2006) 1.72

Distribution and posttranslational modification of synaptic ERα in the adult female rat hippocampus. Endocrinology (2012) 1.52

Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol (2008) 1.47

Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem (2008) 1.44

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol (2004) 1.43

Retracted Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer. Mol Cancer (2013) 1.41

Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Mol Endocrinol (2010) 1.40

Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin. Endocrinology (2008) 1.31

Membrane oestrogen receptor alpha signalling to cell functions. J Physiol (2009) 1.25

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A (2009) 1.23

Membrane estradiol signaling in the brain. Front Neuroendocrinol (2009) 1.22

The role of caveolin-1 in prostate cancer: clinical implications. Prostate Cancer Prostatic Dis (2009) 1.20

Estrogen Regulation of MicroRNA Expression. Curr Genomics (2009) 1.20

Rapid signaling by steroid receptors. Am J Physiol Regul Integr Comp Physiol (2008) 1.18

Physiological consequences of membrane-initiated estrogen signaling in the brain. Front Biosci (Landmark Ed) (2011) 1.18

Estrogen regulation of testicular function. Reprod Biol Endocrinol (2005) 1.17

Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell (2009) 1.17

Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cells. Mol Endocrinol (2008) 1.14

Non-nuclear estrogen receptor signaling in the endothelium. J Biol Chem (2011) 1.13

Endocrinology and hormone therapy in breast cancer: new insight into estrogen receptor-alpha function and its implication for endocrine therapy resistance in breast cancer. Breast Cancer Res (2005) 1.12

Vascular cell signaling by membrane estrogen receptors. Steroids (2008) 1.11

Membrane-initiated actions of estrogen on the endothelium. Mol Cell Endocrinol (2009) 1.10

Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation. Circ Res (2003) 1.10

Interaction between P2X3 and oestrogen receptor (ER)α/ERβ in ATP-mediated calcium signalling in mice sensory neurones. J Neuroendocrinol (2012) 1.08

Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol Appl Pharmacol (2007) 1.08

Rapid modulation of osteoblast ion channel responses by 1alpha,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor. Proc Natl Acad Sci U S A (2004) 1.07

Signal integration through blending, bolstering and bifurcating of intracellular information. Nat Struct Mol Biol (2010) 1.07

Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane. Mol Cell Biol (2010) 1.05

Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305. Breast Cancer Res Treat (2009) 1.05

Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons. J Neurosci (2010) 1.04

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol Biol Cell (2011) 1.04

Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane. Neuroscience (2008) 1.03

Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proc Natl Acad Sci U S A (2003) 1.03

Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. J Biol Chem (2011) 1.01

Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals. Front Physiol (2012) 1.01

Nervous system physiology regulated by membrane estrogen receptors. Rev Neurosci (2008) 1.01

Caveolin proteins and estrogen signaling in the brain. Mol Cell Endocrinol (2008) 0.99

Estradiol signaling in the regulation of reproduction and energy balance. Front Neuroendocrinol (2012) 0.99

Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway. Environ Health Perspect (2010) 0.99

Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP). Mol Endocrinol (2011) 0.98

Rapid control of male typical behaviors by brain-derived estrogens. Front Neuroendocrinol (2012) 0.95

Viral vector-mediated overexpression of estrogen receptor-alpha in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release. J Neurosci (2009) 0.94

Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer (2004) 0.93

p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. Breast Cancer Res (2006) 0.92

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function. Br J Cancer (2004) 0.91

Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor α protein in MCF-7 cells require the CSK c-Src tyrosine kinase. PLoS One (2013) 0.90

The Effects of 17β-estradiol in Cancer are Mediated by Estrogen Receptor Signaling at the Plasma Membrane. Front Physiol (2011) 0.90

Estrogen actions on neuroendocrine glia. Neuroendocrinology (2010) 0.89

Converse regulatory functions of estrogen receptor-alpha and -beta subtypes expressed in hypothalamic gonadotropin-releasing hormone neurons. Mol Endocrinol (2008) 0.88

Cyclin D1 integrates estrogen-mediated DNA damage repair signaling. Cancer Res (2014) 0.87

The multifaceted mineralocorticoid receptor. Compr Physiol (2014) 0.85

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. J Biomed Sci (2011) 0.84

Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons. Brain Res (2011) 0.84

Splice isoform estrogen receptors as integral transmembrane proteins. Mol Biol Cell (2011) 0.84

17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo. J Pharmacol Exp Ther (2010) 0.83

Does a nonclassical signaling mechanism underlie an increase of estradiol-mediated gonadotropin-releasing hormone receptor binding in ovine pituitary cells? Biol Reprod (2011) 0.83

Point mutations in the ERα Gαi binding domain segregate nonnuclear from nuclear receptor function. Mol Endocrinol (2012) 0.82

Rapid actions of xenoestrogens disrupt normal estrogenic signaling. Steroids (2013) 0.82

Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids (2013) 0.82

Non-genomic effects of xenoestrogen mixtures. Int J Environ Res Public Health (2012) 0.81

Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. J Reprod Dev (2013) 0.81

Paired hormone response elements predict caveolin-1 as a glucocorticoid target gene. PLoS One (2010) 0.81

Corticosteroids: way upstream. Mol Brain (2010) 0.81

The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System. Circ Res (2016) 0.81

Endothelial estrogen receptor isoforms and cardiovascular disease. Mol Cell Endocrinol (2014) 0.80

Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing. PLoS One (2014) 0.80

Gαo potentiates estrogen receptor α activity via the ERK signaling pathway. J Endocrinol (2012) 0.79

Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitors. Clin Cancer Res (2011) 0.78

Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior. Front Endocrinol (Lausanne) (2015) 0.77

Classical nuclear hormone receptor activity as a mediator of complex concentration response relationships for endocrine active compounds. Curr Opin Pharmacol (2014) 0.77

GPR30 FORMS AN INTEGRAL PART OF E2-PROTECTIVE PATHWAY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. Immunol Endocr Metab Agents Med Chem (2011) 0.77

Cholesterol and phytosterols differentially regulate the expression of caveolin 1 and a downstream prostate cell growth-suppressor gene. Cancer Epidemiol (2010) 0.76

Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function. Front Immunol (2017) 0.75

Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling. Neuroendocrinology (2016) 0.75

Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity. Breast Cancer Res (2004) 0.75

Rodent Models of Non-classical Progesterone Action Regulating Ovulation. Front Endocrinol (Lausanne) (2017) 0.75

Androgen Receptor Localizes to Plasma Membrane by Binding to Caveolin-1 in Mouse Sertoli Cells. Int J Endocrinol (2017) 0.75

Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog (2017) 0.75

Articles cited by this

Mammalian G1 cyclins. Cell (1993) 9.04

The caveolae membrane system. Annu Rev Biochem (1998) 7.54

Specific protection against breast cancers by cyclin D1 ablation. Nature (2001) 6.94

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem (1998) 6.26

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem (1995) 6.25

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol (2000) 5.53

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem (1996) 5.42

BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature (2001) 5.31

Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature (2000) 4.92

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell (2001) 4.78

Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol Endocrinol (1999) 3.74

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J (1996) 3.59

Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells. Nature (1977) 3.04

Immunochemical studies of estrogen receptors. J Steroid Biochem (1984) 2.55

Structural organization and expression of the mouse estrogen receptor. Mol Endocrinol (1987) 2.54

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci U S A (1994) 2.41

ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol (2002) 2.20

Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology (1997) 2.05

Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev (1993) 2.05

Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res (2000) 1.86

Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci U S A (2000) 1.83

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cell Signal (1996) 1.75

Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem (2001) 1.72

Estrogen receptor beta acts as a dominant regulator of estrogen signaling. Oncogene (2000) 1.62

Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i). J Biol Chem (2001) 1.61

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J (1999) 1.54

Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells. Oncogene (2001) 1.54

Estrogen receptor-alpha detected on the plasma membrane of aldehyde-fixed GH3/B6/F10 rat pituitary tumor cells by enzyme-linked immunocytochemistry. Endocrinology (1999) 1.53

Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol (2000) 1.46

Nongenomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. J Clin Endocrinol Metab (1995) 1.36

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem (2001) 1.35

Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem (2000) 1.33

Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochem Biophys Res Commun (1999) 1.32

Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem (1998) 1.27

Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology (2001) 1.26

Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression. J Biol Chem (2000) 1.22

Glycosyl-phosphatidylinositol anchoring of membrane proteins. Curr Top Microbiol Immunol (1992) 1.20

Cellular Functions of the Plasma Membrane Estrogen Receptor. Trends Endocrinol Metab (1999) 1.18

Estrogen and progesterone inhibit vascular smooth muscle proliferation. Endocrinology (1997) 1.14

Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell Growth Differ (2000) 1.13

Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells. Mol Endocrinol (2000) 1.10

Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J (2001) 1.07

Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells. Breast Cancer Res Treat (1994) 1.07

Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors. J Bone Miner Res (1993) 1.06

Phospholipase C beta and membrane action of calcitriol and estradiol. J Biol Chem (1997) 1.05

Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem (2001) 0.96

Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology (1998) 0.90

Estrogen-induced resistance to osteoblast apoptosis is associated with increased hsp27 expression. J Cell Physiol (2000) 0.88

Identification of the quinone cofactor in mammalian semicarbazide-sensitive amine oxidase. Biochemistry (1998) 0.80

Articles by these authors

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res (2007) 5.63

TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol (2004) 3.12

Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem (2011) 2.97

Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol (2006) 2.90

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res (2008) 2.76

Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. BMJ (2013) 2.74

Extranuclear steroid receptors: nature and actions. Endocr Rev (2007) 2.72

Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol (2005) 2.45

A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem (2007) 2.34

Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem (2002) 2.31

ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol (2002) 2.20

Plasma membrane estrogen receptors exist and functions as dimers. Mol Endocrinol (2004) 2.00

A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A (2007) 1.97

Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem (2002) 1.95

Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov (2009) 1.92

Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell (2006) 1.72

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem (2007) 1.67

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem (2004) 1.66

Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry (2009) 1.63

Estimating changes in mean body temperature for humans during exercise using core and skin temperatures is inaccurate even with a correction factor. J Appl Physiol (1985) (2007) 1.62

Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem (2002) 1.60

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52

Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology (2012) 1.52

Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem (2005) 1.51

Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem (2008) 1.44

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol (2004) 1.43

Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta. J Biol Chem (2005) 1.41

Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A (2011) 1.39

Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. J Biol Chem (2005) 1.39

p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res (2002) 1.36

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem (2005) 1.32

Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci (2010) 1.31

Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin. Endocrinology (2008) 1.31

Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28

Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab (2004) 1.28

Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27

Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004. J Gen Virol (2006) 1.25

Estrogen receptor-beta prevents cardiac fibrosis. Mol Endocrinol (2010) 1.24

Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J Mol Biol (2006) 1.22

Requirements for estrogen receptor alpha membrane localization and function. Steroids (2005) 1.22

Minireview: Recent advances in extranuclear steroid receptor actions. Endocrinology (2011) 1.20

Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. J Steroid Biochem Mol Biol (2008) 1.19

Thyroxine-thyroid hormone receptor interactions. J Biol Chem (2004) 1.17

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17

Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. J Biol Chem (2002) 1.17

Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell (2009) 1.17

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. J Med Chem (2009) 1.17

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol (2007) 1.10

Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem (2005) 1.10

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE (2006) 1.08

Thyroid hormone response element organization dictates the composition of active receptor. J Biol Chem (2007) 1.07

Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A (2011) 1.06

Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane. Mol Cell Biol (2010) 1.05

Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc Natl Acad Sci U S A (2009) 1.05

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol Biol Cell (2011) 1.04

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem (2005) 1.03

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M. J Cell Sci (2002) 1.02

Mode of peroxisome proliferator-activated receptor γ activation by luteolin. Mol Pharmacol (2012) 1.01

Estrogen signaling in the cardiovascular system. Nucl Recept Signal (2006) 1.00

The Snellen human calorimeter revisited, re-engineered and upgraded: design and performance characteristics. Med Biol Eng Comput (2006) 1.00

A three-compartment thermometry model for the improved estimation of changes in body heat content. Am J Physiol Regul Integr Comp Physiol (2006) 0.99

Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology (2011) 0.99

Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling. Sci Signal (2013) 0.99

Estrogen regulates histone deacetylases to prevent cardiac hypertrophy. Mol Biol Cell (2013) 0.99

Molecular dynamics simulations reveal multiple pathways of ligand dissociation from thyroid hormone receptors. Biophys J (2005) 0.98

Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry (2008) 0.98

Molecular dynamics simulations of ligand dissociation from thyroid hormone receptors: evidence of the likeliest escape pathway and its implications for the design of novel ligands. J Med Chem (2006) 0.98

Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists. PLoS One (2012) 0.97

Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes. BMC Med Genomics (2011) 0.97

Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β. Cardiovasc Res (2010) 0.97

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. Am J Physiol Endocrinol Metab (2013) 0.95

Ligand dissociation from estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations. Mol Endocrinol (2008) 0.93

Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology (2002) 0.93

Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol (2005) 0.92

Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization. J Mol Biol (2013) 0.91

Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res (2012) 0.91

A peroxisome proliferator-activated receptor gamma (PPARgamma)/PPARgamma coactivator 1beta autoregulatory loop in adipocyte mitochondrial function. J Biol Chem (2011) 0.90

GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem (2012) 0.90

Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide. Am J Physiol Heart Circ Physiol (2005) 0.89

Negative regulation of superoxide dismutase-1 promoter by thyroid hormone. Mol Pharmacol (2006) 0.89

Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry (2013) 0.89

E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode. Proc Natl Acad Sci U S A (2005) 0.89

A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor. Nucl Recept (2004) 0.88

Calorimetric measurement of postexercise net heat loss and residual body heat storage. Med Sci Sports Exerc (2008) 0.87

Metabolism: bile acids heat things up. Nature (2006) 0.87

Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol (2008) 0.87

Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes. Hepatology (2012) 0.87

Allosteric conversation in the androgen receptor ligand-binding domain surfaces. Mol Endocrinol (2012) 0.87

Estrogen modulates metabolic pathway adaptation to available glucose in breast cancer cells. Mol Endocrinol (2012) 0.85

Estrogen receptors and cell signaling. Science (2005) 0.85

Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1). J Med Chem (2011) 0.85