Published in J Neurosci on August 07, 2013
Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2. PLoS Biol (2014) 1.57
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife (2016) 0.83
The sheddase ADAM10 is a potent modulator of prion disease. Elife (2015) 0.83
Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci (2014) 0.80
Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25-35). Neural Regen Res (2014) 0.79
Shedding light on prion disease. Prion (2015) 0.79
CART treatment improves memory and synaptic structure in APP/PS1 mice. Sci Rep (2015) 0.78
Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity. Front Mol Neurosci (2017) 0.77
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus. Front Cell Neurosci (2015) 0.75
Promoter Variants of the ADAM10 Gene and Their Roles in Temporal Lobe Epilepsy. Front Neurol (2016) 0.75
Not just amyloid: physiological functions of the amyloid precursor protein family. Nat Rev Neurosci (2017) 0.75
Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway. Mol Ther Nucleic Acids (2017) 0.75
Proteases at work: cues for understanding neural development and degeneration. Front Mol Neurosci (2015) 0.75
Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation (2017) 0.75
APP Causes Hyperexcitability in Fragile X Mice. Front Mol Neurosci (2016) 0.75
Shedding the epilepsy comorbidity in Alzheimer's disease. Epilepsy Curr (2014) 0.75
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms. Front Mol Neurosci (2017) 0.75
APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci (2017) 0.75
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα. Front Mol Neurosci (2017) 0.75
Genetic variants of increased waist circumference in psychosis. Psychiatr Genet (2017) 0.75
Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders. Front Cell Neurosci (2017) 0.75
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci (2012) 4.92
Control of peripheral nerve myelination by the beta-secretase BACE1. Science (2006) 4.55
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov (2011) 4.24
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep (2002) 3.53
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood (2003) 3.51
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell (2007) 3.49
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol (2003) 3.26
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J (2007) 2.97
Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci (2009) 2.96
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J (2005) 2.95
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. Lancet Neurol (2005) 2.91
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J (2012) 2.72
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci (2004) 2.70
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (2012) 2.65
Genetic prion disease: the EUROCJD experience. Hum Genet (2005) 2.64
Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta (2008) 2.60
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends Genet (2003) 2.54
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther (2011) 2.51
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain (2012) 2.49
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. Mol Biol Cell (2009) 2.46
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (2009) 2.43
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell (2006) 2.43
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell (2002) 2.37
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature (2012) 2.36
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (2009) 2.35
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. Semin Cell Dev Biol (2008) 2.31
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 2.29
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathol (2013) 2.27
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J (2010) 2.26
Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell (2002) 2.25
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke. Circ Res (2013) 2.21
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol (2004) 2.19
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem (2005) 2.15
Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest (2003) 2.14
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing. Ann Neurol (2011) 2.11
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem (2003) 2.05
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science (2010) 2.03
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
A critical function of the pial basement membrane in cortical histogenesis. J Neurosci (2002) 2.00
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci (2005) 2.00
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Science (2011) 1.98
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. EMBO J (2005) 1.96
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol (2004) 1.90
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis (2008) 1.89
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J (2006) 1.88
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci (2010) 1.85
Shaken baby syndrome: a common variant of non-accidental head injury in infants. Dtsch Arztebl Int (2009) 1.83
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol (2006) 1.83
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet (2010) 1.83
The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell (2011) 1.82
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med (2010) 1.80
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. J Cell Sci (2003) 1.79
A cell biological perspective on Alzheimer's disease. Annu Rev Cell Dev Biol (2002) 1.79
Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet (2006) 1.76
Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J Neurosci (2006) 1.75
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J Neurosci (2004) 1.74
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72