Published in EMBO J on April 13, 2012
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The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase. Elife (2016) 0.84
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Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nat Commun (2014) 0.84
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Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease. EMBO J (2012) 0.82
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med (2016) 0.81
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Biological function of Presenilin and its role in AD pathogenesis. Transl Neurodegener (2013) 0.81
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Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein. PLoS One (2014) 0.79
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proc Natl Acad Sci U S A (2016) 0.79
Structural biology: Membrane enzyme cuts a fine figure. Nature (2012) 0.79
Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities. Expert Rev Mol Diagn (2015) 0.79
Mechanism of intramembrane cleavage of alcadeins by γ-secretase. PLoS One (2013) 0.78
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun (2015) 0.78
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations. FEBS Open Bio (2014) 0.78
γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ. Eur J Neurosci (2013) 0.78
Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. Biochemistry (2016) 0.77
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. Int J Alzheimers Dis (2014) 0.77
Physiological and pathological roles of the γ-secretase complex. Brain Res Bull (2016) 0.76
Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics. Front Neurol (2015) 0.76
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease. Alzheimers Res Ther (2016) 0.76
Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease. Alzheimers Res Ther (2015) 0.76
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS One (2015) 0.75
Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol Aging (2016) 0.75
Presenilin E318G variant and Alzheimer's disease risk: the Cache County study. BMC Genomics (2016) 0.75
Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. Stem Cell Reports (2017) 0.75
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Mol Neurodegener (2017) 0.75
Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease. Curr Genet Med Rep (2015) 0.75
γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase. ACS Chem Biol (2015) 0.75
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol Neurodegener (2017) 0.75
Dementia and molecule of the month APP. Bioinformation (2012) 0.75
Inferring data-specific micro-RNA function through the joint ranking of micro-RNA and pathways from matched micro-RNA and gene expression data. Bioinformatics (2015) 0.75
Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease. Neurobiol Aging (2016) 0.75
The effects of different familial Alzheimer's disease mutations on APP processing in vivo. Alzheimers Res Ther (2017) 0.75
Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer's disease. Alzheimers Res Ther (2013) 0.75
Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential? Future Neurol (2015) 0.75
Probing γ-secretase-substrate interactions at the single amino acid residue level. EMBO J (2016) 0.75
An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. J Biol Chem (2016) 0.75
Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO Mol Med (2017) 0.75
Enzymatic Assays for Studying Intramembrane Proteolysis. Methods Enzymol (2016) 0.75
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