Published in Cell on September 07, 1990
RNA editing in kinetoplastid protozoa. Microbiol Mol Biol Rev (1997) 2.58
Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates. Curr Genet (2005) 2.01
The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria. Nucleic Acids Res (1997) 1.89
Guide RNAs for transcripts with developmentally regulated RNA editing are present in both life cycle stages of Trypanosoma brucei. Mol Cell Biol (1992) 1.79
Specific cleavage of pre-edited mRNAs in trypanosome mitochondrial extracts. Mol Cell Biol (1992) 1.63
Trypanosoma equiperdum minicircles encode three distinct primary transcripts which exhibit guide RNA characteristics. Mol Cell Biol (1991) 1.57
Comparative analysis of editosome proteins in trypanosomatids. Nucleic Acids Res (2003) 1.52
Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils. EMBO J (1997) 1.46
Maxicircle CR1 transcripts of Trypanosoma brucei are edited and developmentally regulated and encode a putative iron-sulfur protein homologous to an NADH dehydrogenase subunit. Mol Cell Biol (1992) 1.38
Mitochondrial tRNAs in the lower fungus Spizellomyces punctatus: tRNA editing and UAG 'stop' codons recognized as leucine. Nucleic Acids Res (1997) 1.36
Trypanosoma brucei minicircles encode multiple guide RNAs which can direct editing of extensively overlapping sequences. Nucleic Acids Res (1993) 1.35
Conserved genes encode guide RNAs in mitochondria of Crithidia fasciculata. EMBO J (1991) 1.29
Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity. EMBO Rep (2006) 1.22
An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12. Mol Cell Biol (1992) 1.22
Editing domains of Trypanosoma brucei mitochondrial RNAs identified by secondary structure. Mol Cell Biol (1995) 1.21
U-insertion/deletion Edited Sequence Database. Nucleic Acids Res (1998) 1.20
Chimeric and truncated RNAs in Trypanosoma brucei suggest transesterifications at non-consecutive sites during RNA editing. Nucleic Acids Res (1992) 1.19
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
Editing of Trypanosoma brucei maxicircle CR5 mRNA generates variable carboxy terminal predicted protein sequences. Nucleic Acids Res (1994) 1.05
Extensive editing of CR2 maxicircle transcripts of Trypanosoma brucei predicts a protein with homology to a subunit of NADH dehydrogenase. Mol Cell Biol (1993) 1.03
Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversity. PLoS One (2008) 1.00
The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei. Biochem J (1994) 1.00
Computer methods for locating kinetoplastid cryptogenes. Nucleic Acids Res (1992) 0.98
Novel pattern of editing regions in mitochondrial transcripts of the cryptobiid Trypanoplasma borreli. EMBO J (1994) 0.98
Phylogenetic analysis of RNA editing: a primitive genetic phenomenon. Proc Natl Acad Sci U S A (1994) 0.98
An intragenic guide RNA location suggests a complex mechanism for mitochondrial gene expression in Trypanosoma brucei. Eukaryot Cell (2004) 0.96
Implications of novel guide RNA features for the mechanism of RNA editing in Crithidia fasciculata. EMBO J (1993) 0.93
The insect-phase gRNA transcriptome in Trypanosoma brucei. Nucleic Acids Res (2013) 0.93
Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae. Mol Biochem Parasitol (2007) 0.92
Additive and transcript-specific effects of KPAP1 and TbRND activities on 3' non-encoded tail characteristics and mRNA stability in Trypanosoma brucei. PLoS One (2012) 0.92
The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei. PLoS One (2010) 0.89
Enigmatic presence of mitochondrial complex I in Trypanosoma brucei bloodstream forms. Eukaryot Cell (2011) 0.88
A novel member of the RNase D exoribonuclease family functions in mitochondrial guide RNA metabolism in Trypanosoma brucei. J Biol Chem (2011) 0.86
Mechanism of U insertion RNA editing in trypanosome mitochondria: the bimodal TUTase activity of the core complex. J Mol Biol (2010) 0.85
Mechanism of U-insertion RNA editing in trypanosome mitochondria: characterization of RET2 functional domains by mutational analysis. J Mol Biol (2010) 0.85
NADH dehydrogenase subunit genes in the mitochondrial DNA of yeasts. J Bacteriol (1994) 0.85
Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei. J Biol Chem (2015) 0.81
High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing. RNA (2016) 0.78
Maxicircle DNA and edited mRNA sequences of closely related trypanosome species: implications of kRNA editing for evolution of maxicircle genomes. Nucleic Acids Res (1993) 0.78
The impact of mRNA structure on guide RNA targeting in kinetoplastid RNA editing. PLoS One (2010) 0.78
Complete set of mitochondrial pan-edited mRNAs in Leishmania mexicana amazonensis LV78. Mol Biochem Parasitol (2010) 0.77
Evidence of RNA editing in Leishmania braziliensis promastigotes. Parasitol Res (2010) 0.76
The Architecture of Trypanosoma brucei editosomes. Proc Natl Acad Sci U S A (2016) 0.76
Analysis of the Trypanosoma brucei EATRO 164 Bloodstream Guide RNA Transcriptome. PLoS Negl Trop Dis (2016) 0.75
In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases. Nucleic Acids Res (2017) 0.75
Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial. Lancet (2004) 4.25
RNA editing: a mechanism for gRNA-specified uridylate insertion into precursor mRNA. Science (1996) 3.75
Direct visualization of uridylate deletion in vitro suggests a mechanism for kinetoplastid RNA editing. Cell (1996) 3.55
An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science (2001) 3.52
Extensive editing of the cytochrome c oxidase III transcript in Trypanosoma brucei. Cell (1988) 3.26
Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei. Cell (1983) 2.53
Developmentally regulated addition of nucleotides within apocytochrome b transcripts in Trypanosoma brucei. Cell (1987) 2.43
RNA editing: transfer of genetic information from gRNA to precursor mRNA in vitro. Science (1994) 2.43
An extensively edited mitochondrial transcript in kinetoplastids encodes a protein homologous to ATPase subunit 6. Cell (1990) 2.38
Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes. Proc Natl Acad Sci U S A (1999) 2.37
Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons. Cell (1988) 2.32
In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing. Nature (1992) 2.30
Syphilis intervention in pregnancy: Zambian demonstration project. Genitourin Med (1990) 2.27
Uridylate addition and RNA ligation contribute to the specificity of kinetoplastid insertion RNA editing. Mol Cell Biol (2000) 2.20
Trypanosoma brucei gBP21. An arginine-rich mitochondrial protein that binds to guide RNA with high affinity. J Biol Chem (1997) 2.17
LR1: a candidate RNA virus of Leishmania. Proc Natl Acad Sci U S A (1988) 2.11
Syphilis in pregnant women in Zambia. Br J Vener Dis (1982) 2.05
The IsTaR 1 serodeme of Trypanosoma brucei: development of a new serodeme. J Parasitol (1984) 2.03
Guide RNAs for transcripts with developmentally regulated RNA editing are present in both life cycle stages of Trypanosoma brucei. Mol Cell Biol (1992) 1.79
Rapid voluntary testing and counseling for HIV. Acceptability and feasibility in Zambian antenatal care clinics. Ann N Y Acad Sci (2000) 1.69
The secondary structure of guide RNA molecules from Trypanosoma brucei. Nucleic Acids Res (1995) 1.66
Multiple guide RNAs for identical editing of Trypanosoma brucei apocytochrome b mRNA have an unusual minicircle location and are developmentally regulated. J Biol Chem (1994) 1.66
Extensive editing of both processed and preprocessed maxicircle CR6 transcripts in Trypanosoma brucei. J Biol Chem (1992) 1.64
Cycles of progressive realignment of gRNA with mRNA in RNA editing. Cell (1991) 1.62
Have malaria parasites three genomes? Parasitol Today (1991) 1.61
Apocytochrome b and other mitochondrial DNA sequences are differentially expressed during the life cycle of Trypanosoma brucei. Nucleic Acids Res (1985) 1.57
Creation of AUG initiation codons by addition of uridines within cytochrome b transcripts of kinetoplastids. Proc Natl Acad Sci U S A (1988) 1.54
Kinetoplast DNA, mitochondrial DNA with a difference. Mol Biochem Parasitol (1983) 1.54
Developmental aspects of uridine addition within mitochondrial transcripts of Trypanosoma brucei. Mol Cell Biol (1988) 1.53
Characterization of cytochrome c oxidase III transcripts that are edited only in the 3' region. Cell (1988) 1.52
Early congenital syphilis: clinico-radiologic features in 202 patients. Sex Transm Dis (1986) 1.50
Comparison of the maxicircle (mitochondrial) genomes of Leishmania tarentolae and Trypanosoma brucei at the level of nucleotide sequence. J Biol Chem (1987) 1.49
Congenital syphilis in Lusaka--i. Incidence in a general nursery ward. East Afr Med J (1982) 1.46
Influencing sexual practices among HIV-positive Zambian women. AIDS Care (2006) 1.42
Perinatal transmission of HIV-I in Zambia. BMJ (1989) 1.41
Transcript-specific developmental regulation of polyadenylation in Trypanosoma brucei mitochondria. Mol Biochem Parasitol (1992) 1.39
Maxicircle CR1 transcripts of Trypanosoma brucei are edited and developmentally regulated and encode a putative iron-sulfur protein homologous to an NADH dehydrogenase subunit. Mol Cell Biol (1992) 1.38
Analysis of targeting sequences demonstrates that trafficking to the Toxoplasma gondii plastid branches off the secretory system. J Cell Sci (2000) 1.35
Assembly of mitochondrial ribonucleoprotein complexes involves specific guide RNA (gRNA)-binding proteins and gRNA domains but does not require preedited mRNA. Mol Cell Biol (1994) 1.35
Trypanosoma brucei minicircles encode multiple guide RNAs which can direct editing of extensively overlapping sequences. Nucleic Acids Res (1993) 1.35
Different Trypanosoma brucei guide RNA molecules associate with an identical complement of mitochondrial proteins in vitro. Nucleic Acids Res (1994) 1.34
Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8. Virology (1999) 1.32
The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei. Proc Natl Acad Sci U S A (1994) 1.32
Mitochondrial DNA of kinetoplastids. Int Rev Cytol (1992) 1.29
Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B. J Hum Virol (2001) 1.28
Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei. Proc Natl Acad Sci U S A (1985) 1.25
The community control of rheumatic fever and rheumatic heart disease: report of a WHO international cooperative project. Bull World Health Organ (1981) 1.25
Organisation and expression of small subunit ribosomal RNA genes encoded by a 35-kilobase circular DNA in Plasmodium falciparum. Mol Biochem Parasitol (1991) 1.25
Sequence organization in African trypanosome minicircles is defined by 18 base pair inverted repeats. Mol Biochem Parasitol (1986) 1.25
Molecular characterization of initial variants from the IsTat I serodeme of Trypanosoma brucei. Mol Biochem Parasitol (1983) 1.23
The effect of routine hospital care on the health of hypothermic newborn infants in Zambia. J Trop Pediatr (1995) 1.22
Diverse patterns of expression of the cytochrome c oxidase subunit I gene and unassigned reading frames 4 and 5 during the life cycle of Trypanosoma brucei. Mol Cell Biol (1985) 1.22
Mitochondrial DNA of an African trypanosome. J Cell Biochem (1983) 1.20
Chimeric and truncated RNAs in Trypanosoma brucei suggest transesterifications at non-consecutive sites during RNA editing. Nucleic Acids Res (1992) 1.19
Structural analysis of variant and invariant genes in trypanosomes. Am J Trop Med Hyg (1980) 1.18
Transcribing and replicating particles in a double-stranded RNA virus from Leishmania. Mol Biochem Parasitol (1992) 1.17
Antigenic variation in African trypanosomes by gene replacement or activation of alternate telomeres. Cell (1984) 1.17
Variant antigen genes of Trypanosoma brucei: genomic alteration of a spliced leader orphon and retention of expression-linked copies during differentiation. Proc Natl Acad Sci U S A (1984) 1.17
Molecular karyotype of species and subspecies of Leishmania. Mol Biochem Parasitol (1986) 1.17
The size difference between leishmania major friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end. Mol Biochem Parasitol (2000) 1.16
The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins. Mol Cell Biol (1990) 1.15
Congenital syphilis in Lusaka--III. Incidence in the neonatal intensive-care unit. East Afr Med J (1982) 1.15
Trypanosoma brucei mitochondrial CR4 gene encodes an extensively edited mRNA with completely edited sequence only in bloodstream forms. Mol Biochem Parasitol (1994) 1.13
Structural organization of the maxicircle variable region of Trypanosoma brucei: identification of potential replication origins and topoisomerase II binding sites. Nucleic Acids Res (1993) 1.13
Distribution and sequence divergence of LRV1 viruses among different Leishmania species. Mol Biochem Parasitol (1992) 1.13
Genomic organization and functional characterization of the Leishmania major Friedlin ribosomal RNA gene locus. Mol Biochem Parasitol (2001) 1.11
Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastatic colorectal cancer. Ann Oncol (2007) 1.10
(TAA)n within sequences flanking several intrachromosomal variant surface glycoprotein genes in Trypanosoma brucei. Nucleic Acids Res (1985) 1.10
Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei. Nature (1984) 1.10
Differential mitochondrial gene expression between slender and stumpy bloodforms of Trypanosoma brucei. Mol Biochem Parasitol (1986) 1.07
Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria. Trans R Soc Trop Med Hyg (1998) 1.07
Randomised study of skin-to-skin versus incubator care for rewarming low-risk hypothermic neonates. Lancet (1998) 1.07
Tetracycline regulated gene expression in Leishmania donovani. Mol Biochem Parasitol (2001) 1.05
The unusual gene organization of Leishmania major chromosome 1 may reflect novel transcription processes. Nucleic Acids Res (2000) 1.05
Developmental regulation of RNA editing and polyadenylation in four life cycle stages of Trypanosoma congolense. Mol Biochem Parasitol (1994) 1.05
Editing of Trypanosoma brucei maxicircle CR5 mRNA generates variable carboxy terminal predicted protein sequences. Nucleic Acids Res (1994) 1.05
Leishmania RNA viruses in Leishmania of the Viannia subgenus. Am J Trop Med Hyg (1996) 1.04
Recurrent polymorphisms in small chromosomes of Leishmania tarentolae after nutrient stress or subcloning. Mol Biochem Parasitol (1992) 1.03
Conservation of kinetoplastid minicircle characteristics without nucleotide sequence conservation. Mol Biochem Parasitol (1986) 1.03
Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames. Mol Biochem Parasitol (1985) 1.03
LRV1 viral particles in Leishmania guyanensis contain double-stranded or single-stranded RNA. J Virol (1992) 1.03
Molecular mechanisms of angiotensin II in modulating cardiac function: intracardiac effects and signal transduction pathways. J Mol Cell Cardiol (1997) 1.02
Genomic organization of Trypanosoma brucei variant antigen gene families in sequential parasitemias. Mol Biochem Parasitol (1983) 1.01
A family of repeated DNA sequences, one of which resides in the second intervening sequence of the mouse dihydrofolate reductase gene. J Biol Chem (1983) 0.99
The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum have short A tails. Nucleic Acids Res (1999) 0.99