The CRISPR craze.

Unravelling the structural and mechanistic basis of CRISPR-Cas systems. Nat Rev Microbiol (2014) 3.48

CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity. Mol Cell (2014) 2.87

Classification and evolution of type II CRISPR-Cas systems. Nucleic Acids Res (2014) 1.91

Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Nat Commun (2014) 1.88

CRISPR-Cas immunity in prokaryotes. Nature (2015) 1.75

CRISPR-based technologies: prokaryotic defense weapons repurposed. Trends Genet (2014) 1.60

Efficient gene editing in tomato in the first generation using the clustered regularly interspaced short palindromic repeats/CRISPR-associated9 system. Plant Physiol (2014) 1.53

A CRISPR/Cas9 toolkit for multiplex genome editing in plants. BMC Plant Biol (2014) 1.37

Applications of CRISPR technologies in research and beyond. Nat Biotechnol (2016) 1.34

Twenty years of bacterial genome sequencing. Nat Rev Microbiol (2015) 1.22

Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation. Genome Biol (2015) 1.12

Heritable gene-targeting with gRNA/Cas9 in rats. Cell Res (2013) 1.06

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool. Biotechnol Bioeng (2014) 1.04

The three major types of CRISPR-Cas systems function independently in CRISPR RNA biogenesis in Streptococcus thermophilus. Mol Microbiol (2014) 1.02

Clinical experiences with systemically administered siRNA-based therapeutics in cancer. Nat Rev Drug Discov (2015) 1.02

CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori. Sci Rep (2014) 1.00

Targeted genome modification technologies and their applications in crop improvements. Plant Cell Rep (2013) 0.93

Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. Methods (2014) 0.93

Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway. Sci Rep (2015) 0.91

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing. PLoS One (2015) 0.89

Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing. Parasitology (2016) 0.87

Following-up genome-wide association study signals: lessons learned from Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet (2014) 0.85

"Off-Spotter": very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs. Biol Direct (2015) 0.84

Damaging the Integrated HIV Proviral DNA with TALENs. PLoS One (2015) 0.83

A CRISPR with roles in Myxococcus xanthus development and exopolysaccharide production. J Bacteriol (2014) 0.83

Animal models of subjective tinnitus. Neural Plast (2014) 0.81

Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast. PLoS One (2014) 0.81

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research. Arterioscler Thromb Vasc Biol (2016) 0.81

Visualizing and manipulating temporal signaling dynamics with fluorescence-based tools. Sci Signal (2014) 0.80

Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure (2016) 0.80

The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs. G3 (Bethesda) (2014) 0.80

MegaTevs: single-chain dual nucleases for efficient gene disruption. Nucleic Acids Res (2014) 0.80

Fine-mapping natural alleles: quantitative complementation to the rescue. Mol Ecol (2014) 0.80

Noncoding RNAs and the borders of heterochromatin. Wiley Interdiscip Rev RNA (2014) 0.79

α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. Proc Natl Acad Sci U S A (2016) 0.78

Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter. J Biotechnol (2014) 0.78

Diversity of CRISPR-Cas immune systems and molecular machines. Genome Biol (2015) 0.78

A decade of discovery: CRISPR functions and applications. Nat Microbiol (2017) 0.77

RNAi and Antiviral Defense in the Honey Bee. J Immunol Res (2015) 0.77

Advanced technologies for genetically manipulating the silkworm Bombyx mori, a model Lepidopteran insect. Proc Biol Sci (2015) 0.77

Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system. Sci Rep (2016) 0.76

Recent Advances in Genome Editing Using CRISPR/Cas9. Front Plant Sci (2016) 0.76

Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp. Sci Rep (2016) 0.75

Heat shock in the springtime. Cell Stress Chaperones (2014) 0.75

Editorial: CRISPR in Nucleic Acids Research. Nucleic Acids Res (2016) 0.75

The anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p. RNA Dis (2016) 0.75

Applications of CRISPR/Cas9 in retinal degenerative diseases. Int J Ophthalmol (2017) 0.75

Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens. PLoS One (2014) 0.75

Harnessing mobile genetic elements to explore gene regulation. Mob Genet Elements (2014) 0.75

Role of Recombinant DNA Technology to Improve Life. Int J Genomics (2016) 0.75

Survival and Evolution of CRISPR-Cas System in Prokaryotes and Its Applications. Front Immunol (2016) 0.75

Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress Dis (2014) 0.75

CRISPR-Cas9 directed knock-out of a constitutively expressed gene using lance array nanoinjection. Springerplus (2016) 0.75

Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote. Sci Rep (2017) 0.75

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab (2015) 0.75

CRISPR/Cas9-Mediated Three Nucleotide Insertion Corrects a Deletion Mutation in MRP1/ABCC1 and Restores Its Proper Folding and Function. Mol Ther Nucleic Acids (2017) 0.75

Genetic Engineering and Human Mental Ecology: Interlocking Effects and Educational Considerations. Biosemiotics (2017) 0.75

Taxonomy. Wanted: a barcode for plants. Science (2007) 2.85

Plant genetics. The blue revolution, drop by drop, gene by gene. Science (2008) 2.61

Breakthrough of the year. Human genetic variation. Science (2007) 2.29

DNA data. Proposal to 'Wikify' GenBank meets stiff resistance. Science (2008) 2.23

Modernizing the tree of life. Science (2003) 2.07

Genomics. ENCODE project writes eulogy for junk DNA. Science (2012) 2.05

Armed and dangerous. Science (2010) 1.96

National Science Foundation. Boom in digital collections makes a muddle of management. Science (2005) 1.83

How did cooperative behavior evolve? Science (2005) 1.76

Evolutionary biology. Deciphering the genetics of evolution. Science (2008) 1.65

Breakthrough of the year: evolution in action. Science (2005) 1.63

Evolution. Modernizing the modern synthesis. Science (2008) 1.63

Human genome. A low number wins the GeneSweep Pool. Science (2003) 1.43

Genetics. Honey bee genome illuminates insect evolution and social behavior. Science (2006) 1.42

Human genome 10th anniversary. Will computers crash genomics? Science (2011) 1.40

Genetics. Europe going to the dogs. Science (2007) 1.40

Human genome project. Genome institute wrestles mightily with its future. Science (2002) 1.40

A hothouse of molecular biology. Science (2003) 1.39

Ecology. Rare tree species thrive in local neighborhoods. Science (2006) 1.39

Animal behavior. Strong personalities can pose problems in the mating game. Science (2005) 1.39

Genomics. 1000 Genomes Project gives new map of genetic diversity. Science (2010) 1.21

Plant biology. Stressed out over a stress hormone. Science (2009) 1.20

Genomics. Synthetic genome brings new life to bacterium. Science (2010) 1.18

Genetics. Working the (gene count) numbers: finally, a firm answer? Science (2007) 1.18

Tending the global garden. Science (2010) 1.17

Origins. On the origin of cooperation. Science (2009) 1.15

Genomics. DNA study forces rethink of what it means to be a gene. Science (2007) 1.13

How will big pictures emerge from a sea of biological data? Science (2005) 1.12

Bioinformatics. Gene counters struggle to get the right answer. Science (2003) 1.08

Why do humans have so few genes? Science (2005) 1.08

Systems biology. Tracing life's circuitry. Science (2003) 1.07

What determines species diversity? Science (2005) 1.03

Tending tender tendons. Science (2002) 1.02

Genetics. 17q21.31: not your average genomic address. Science (2008) 1.02

Genomics. On your mark. Get set. Sequence! Science (2006) 1.00

Genomics. Semiconductors inspire new sequencing technologies. Science (2010) 0.99

Data sharing. Group calls for rapid release of more genomics data. Science (2009) 0.99

Sowing the seeds for the ideal crop. Science (2010) 0.94

Neandertal genomics. Tales of a prehistoric human genome. Science (2009) 0.93

The Biology of Genomes. Disease risk links to gene regulation. Science (2011) 0.93

Origins. On the origin of flowering plants. Science (2009) 0.93

The Institute for Genomic Research meeting. Gene researchers hunt bargains, fixer-uppers. Science (2002) 0.93

Meiotic drive. Bickering genes shape evolution. Science (2003) 0.92

Plant sciences. Corn genomics pops wide open. Science (2008) 0.92

Genome sequencing. Search for pore-fection. Science (2012) 0.92

Searching for the genome's second code. Science (2004) 0.89

A mouthful of microbes. Science (2005) 0.89

The man who bottled evolution. Science (2013) 0.89

Changing oceans. Introduction. Science (2010) 0.88

Boom time for monkey research. Science (2007) 0.88

The river masters. Science (2014) 0.88

Shaking up the Tree of Life. Science (2016) 0.87

Synthetic biology. DARPA offers $30 million to jump-start cellular factories. Science (2011) 0.87

Ancient DNA. No sex please, we're Neandertals. Science (2007) 0.87

2013 Society for Integrative and Comparative Biology Annual Meeting. Nervous system may have evolved twice. Science (2013) 0.86

Plant biology. Evolution heresy? Epigenetics underlies heritable plant traits. Science (2013) 0.86

Biochemistry. What poison? Bacterium uses arsenic to build DNA and other molecules. Science (2010) 0.86

Genomicists tackle the primate tree. Science (2007) 0.86

Population genetics. Population geneticists move beyond the single gene. Science (2007) 0.86

Drafting a tree. Science (2003) 0.86

Metagenomics. Massive microbial sequence project proposed. Science (2007) 0.85

Shining a light on the genome's 'dark matter'. Science (2010) 0.85

Microbiology. Modern symbionts inside cells mimic organelle evolution. Science (2014) 0.84

The secret life of fungi. Science (2004) 0.84

A groundbreaking observatory to monitor the environment. Science (2010) 0.84

Research funding. Are epigeneticists ready for big science? Science (2008) 0.83

Plant genetics. How sorghum withstands heat and drought. Science (2009) 0.83

Evolution. How birds got their beaks. Science (2015) 0.83

Genetics. Pollen contamination may explain controversial inheritance. Science (2006) 0.82

Synthetic biology. Synthetic biology remakes small genomes. Science (2005) 0.82

Physiology. Opsins: not just for eyes. Science (2013) 0.82

Evolution and development. Comparative biology joins the molecular age. Science (2002) 0.82

Profile: Ewan Birney. Genomics' big talker. Science (2012) 0.82

Canine evolution. A shaggy dog history. Science (2002) 0.82

Genome sequencing. The greening of plant genomics. Science (2007) 0.81

DNA's cast of thousands. Science (2003) 0.81

Microbiology. Girth and the gut (bacteria). Science (2011) 0.81

Genomics. Sequence tells mouse, human genome secrets. Science (2002) 0.81

Evolutionary biology. The birth of the nucleus. Science (2004) 0.81

Evolutionary medicine. Darwin applies to medical school. Science (2009) 0.81

Conservation. Filling gaps in global biodiversity estimates. Science (2010) 0.81

Evolution. Jumping genes hop into the evolutionary limelight. Science (2007) 0.81

Amphibian decline. Life and death play out on the skins of frogs. Science (2009) 0.81

Cell biology. Lengthy RNAs earn respect as cellular players. Science (2014) 0.81

Mammalian biology: more genomes, but shallower coverage. Science (2004) 0.80

Symbiosis. Fast friends, sworn enemies. Science (2003) 0.80

Plant genetics. Getting to the root of drought responses. Science (2008) 0.80

Microbiology. Researchers trade insights about gene swapping. Science (2004) 0.80

The dynamic gut. Science (2005) 0.80

Animal ecology. Global tracking of small animals gains momentum. Science (2011) 0.80

4th International Symbiosis Society Congress. Fungi shield new host plants from heat and drought. Science (2003) 0.80

Genomics. Charting a genome's hills and valleys. Science (2002) 0.80

Geography. Worth a thousand words. Science (2013) 0.80

Evolutionary biology. Agreeing to disagree. Science (2009) 0.80

Microbiology. Bacteria are picky about their homes on human skin. Science (2008) 0.79

The tale of the TALEs. Science (2012) 0.79

Cultural evolution. Conquering by copying. Science (2010) 0.79

Genetics of behavior. From genes to social behavior. Introduction. Science (2008) 0.79

Genetics. Volvox genome shows it doesn't take much to be multicellular. Science (2010) 0.79

Developmental biology. Bonemaking protein shapes beaks of Darwin's finches. Science (2004) 0.79