Noncoding RNAs and the borders of heterochromatin.

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High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

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CTCF: master weaver of the genome. Cell (2009) 15.09

Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79

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The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85

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Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34

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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99

RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73

Heterochromatin revisited. Nat Rev Genet (2007) 8.70

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CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science (2006) 7.68

Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet (2007) 7.61

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41

The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. Annu Rev Biochem (2003) 7.22

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell (1995) 7.20

Heterochromatin and epigenetic control of gene expression. Science (2003) 7.12

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94

Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88

Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62

Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science (2001) 6.60

Transcriptional noise and the fidelity of initiation by RNA polymerase II. Nat Struct Mol Biol (2007) 6.53

Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48

Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet (2006) 6.43

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science (2001) 6.00

Small RNAs in transcriptional gene silencing and genome defence. Nature (2009) 5.98

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev (2003) 5.77

Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70

Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell (2006) 5.61

A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55

CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell (2004) 5.51

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene (2010) 4.81

RNAi components are required for nuclear clustering of Polycomb group response elements. Cell (2006) 4.70

Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet (2005) 4.66

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36

Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell (2004) 4.34

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J (1999) 4.34

Vernalization-mediated epigenetic silencing by a long intronic noncoding RNA. Science (2010) 4.23

Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol Cell (2001) 4.06

A role for TFIIIC transcription factor complex in genome organization. Cell (2006) 4.03

RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci U S A (2002) 3.52

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49

A chromatin insulator determines the nuclear localization of DNA. Mol Cell (2000) 3.28

RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. EMBO J (2001) 3.20

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet (2013) 3.17

Chromatin boundaries in budding yeast: the nuclear pore connection. Cell (2002) 3.09

Recruitment of histone modifications by USF proteins at a vertebrate barrier element. Mol Cell (2004) 3.08

Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. EMBO Rep (2002) 3.00

Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat Struct Mol Biol (2008) 2.87

Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86

RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science (2004) 2.80

Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats. Mol Cell (2006) 2.72

Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71

Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science (2007) 2.70

Spreading of silent chromatin: inaction at a distance. Nat Rev Genet (2006) 2.64

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci U S A (2000) 2.61

Jpx RNA activates Xist by evicting CTCF. Cell (2013) 2.56

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A (1997) 2.52

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J Exp Med (2008) 2.50

Argonaute slicing is required for heterochromatic silencing and spreading. Science (2006) 2.48

Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell (2005) 2.47

HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts. Mol Cell (2012) 2.36

Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet (2007) 2.35

2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol (2010) 2.30

RNA interference machinery influences the nuclear organization of a chromatin insulator. Nat Genet (2006) 2.22

Retracted A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J (2001) 2.21

The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol Cell (2005) 2.19

Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr Biol (2003) 2.12

A heterochromatin barrier partitions the fission yeast centromere into discrete chromatin domains. Curr Biol (2006) 2.09

Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. Curr Biol (2005) 2.02

Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila. Proc Natl Acad Sci U S A (1996) 1.94

Visualization of chromatin domains created by the gypsy insulator of Drosophila. J Cell Biol (2003) 1.93

CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90

Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell (2007) 1.89

Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev (2010) 1.88

S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell (2007) 1.84

Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82

The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell (2008) 1.81

RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73

Heterochromatin revisited. Nat Rev Genet (2007) 8.70

RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet (2004) 4.23

Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. Mol Cell (2009) 1.45

EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output. Nat Genet (2004) 1.44

Csi1 links centromeres to the nuclear envelope for centromere clustering. J Cell Biol (2012) 1.22

Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J Biol Chem (2009) 1.11

Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions. Genes Dev (2011) 1.00

Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo. Development (2006) 0.98

Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Genes Dev (2013) 0.97

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. J Biol Chem (2011) 0.93

Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly. Genes Dev (2013) 0.89

Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation. Epigenetics (2009) 0.88

Chromosome boundary elements and regulation of heterochromatin spreading. Cell Mol Life Sci (2014) 0.88

Csi1 illuminates the mechanism and function of Rabl configuration. Nucleus (2013) 0.77

Heterochromatin: lost in transcription? Cell Cycle (2008) 0.75

Change of apocytochrome c translocation across membrane in consequence of hydrophobic segment deletion. Mol Cell Biochem (2002) 0.75