Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 3948353)

Published in Chem Biol on August 29, 2013

Authors

Stephen P Holly1, Jae Won Chang, Weiwei Li, Sherry Niessen, Ryan M Phillips, Raymond Piatt, Justin L Black, Matthew C Smith, Yacine Boulaftali, Andrew S Weyrich, Wolfgang Bergmeier, Benjamin F Cravatt, Leslie V Parise

Author Affiliations

1: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: sholly@med.unc.edu.

Articles cited by this

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu Rev Biochem (2008) 4.81

The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72

Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost (2005) 4.64

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood (2011) 3.37

A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa. J Clin Invest (1983) 3.05

A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods (2005) 3.00

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol (2006) 2.98

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A (2002) 2.52

Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46

GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost (2005) 2.42

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc (2007) 2.13

A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol (2011) 1.97

Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome. Blood (2002) 1.90

Activity-based protein profiling for the functional annotation of enzymes. Nat Methods (2007) 1.70

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol (2011) 1.66

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood (2008) 1.41

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. Blood (2009) 1.33

The mechanism of thrombin-induced platelet factor 4 secretion. Blood (1980) 1.27

1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils. J Biol Chem (1989) 1.24

Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. J Lipid Res (2010) 1.20

Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets. Mol Cell Biol (2003) 1.18

Application of activity-based probes to the study of enzymes involved in cancer progression. Curr Opin Genet Dev (2008) 1.17

Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab (2009) 1.16

Clinical pharmacology of eptifibatide. Am J Cardiol (1997) 1.10

Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols. Biochem Biophys Res Commun (1988) 1.05

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity. Mol Cancer Ther (2006) 0.97

Pharmacodynamic profile of short-term abciximab treatment demonstrates prolonged platelet inhibition with gradual recovery from GP IIb/IIIa receptor blockade. Circulation (1998) 0.96

Structural and chemical specificity of diacylglycerols for protein kinase C activation. Biochem Biophys Res Commun (1984) 0.96

A potential role for α-actinin in inside-out αIIbβ3 signaling. Blood (2010) 0.90

Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. J Thromb Haemost (2009) 0.88

Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence. J Biol Chem (1997) 0.88

PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood (2009) 0.85

Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets. J Biol Chem (1990) 0.82

Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. Cell Signal (2009) 0.82

1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells. Biochem Biophys Res Commun (1984) 0.81

Articles by these authors

Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20

Profiling enzyme activities in vivo using click chemistry methods. Chem Biol (2004) 5.97

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 5.47

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev (2004) 5.23

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 4.92

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91

Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04

Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood (2009) 3.90

Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell (2008) 3.64

Identification of protein pheromones that promote aggressive behaviour. Nature (2007) 3.55

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (2011) 3.48

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood (2011) 3.37

Structure and function of fatty acid amide hydrolase. Annu Rev Biochem (2005) 3.33

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat Biotechnol (2003) 3.17

Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods (2009) 3.13

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci (2010) 3.11

Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry (2004) 3.10

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med (2004) 3.03

A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods (2005) 3.00

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther (2004) 2.99

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol (2006) 2.98

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol (2005) 2.98

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain (2004) 2.94

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci (2008) 2.87

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol (2009) 2.82

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med (2002) 2.75

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68

Mechanism-based profiling of enzyme families. Chem Rev (2006) 2.66

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64

Platelets as cellular effectors of inflammation in vascular diseases. Circ Res (2013) 2.62

The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest (2004) 2.52

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A (2002) 2.52

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (2002) 2.50

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chem Biol (2009) 2.48

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet (2012) 2.43

Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med (2006) 2.39

Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood (2011) 2.38

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37

A hormone-dependent module regulating energy balance. Cell (2011) 2.30

Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci (2004) 2.29

Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nat Chem Biol (2006) 2.25

The clearance mechanism of chilled blood platelets. Cell (2003) 2.25

Disparate proteome reactivity profiles of carbon electrophiles. Nat Chem Biol (2008) 2.25

Anucleate platelets generate progeny. Blood (2010) 2.24

Systemic antithrombotic effects of ADAMTS13. J Exp Med (2006) 2.21

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis. Ann Surg Oncol (2007) 2.19

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype. Nat Biotechnol (2002) 2.17

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A (2010) 2.16

A tandem orthogonal proteolysis strategy for high-content chemical proteomics. J Am Chem Soc (2005) 2.14

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc (2007) 2.13

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. J Biol Chem (2010) 2.10

Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circ Res (2002) 2.10

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood (2010) 2.10

Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. J Biol Chem (2006) 2.09

Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation. Arterioscler Thromb Vasc Biol (2006) 2.06

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J Cell Biol (2010) 2.05

The expanding role of mass spectrometry in metabolite profiling and characterization. Chembiochem (2005) 2.04

Comparison of Pain Score Reduction Using Triamcinolone vs. Betamethasone in Transforaminal Epidural Steroid Injections for Lumbosacral Radicular Pain. Am J Phys Med Rehabil (2015) 2.03

Activity-based probes for proteomic profiling of histone deacetylase complexes. Proc Natl Acad Sci U S A (2007) 2.03

Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J Pharmacol Exp Ther (2002) 2.01

Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry (2006) 2.01

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem (2010) 2.00

Global profiling of dynamic protein palmitoylation. Nat Methods (2011) 1.99

VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock. Chest (2015) 1.99

Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A (2004) 1.98

A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol (2011) 1.97

Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proc Natl Acad Sci U S A (2004) 1.96

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry (2007) 1.90

The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chem Rev (2011) 1.89

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem (2005) 1.88

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes. Nat Protoc (2007) 1.87

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol (2005) 1.86

Fatty acid amide hydrolase deficiency limits early pregnancy events. J Clin Invest (2006) 1.86

Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer (2010) 1.84

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nat Biotechnol (2009) 1.84

Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase. Curr Biol (2006) 1.83

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A (2007) 1.83

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood (2011) 1.83

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol (2012) 1.79

Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood (2005) 1.78

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol (2005) 1.76

Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol (2008) 1.75

Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol (2011) 1.74