Published in FEBS Lett on September 08, 2013
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Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
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An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. J Biol Chem (2002) 1.37
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat Chem Biol (2011) 1.33
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Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Rep (2013) 0.98
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Biosci Rep (2013) 0.94
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochem (2002) 0.93
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Preparation of quality inositol pyrophosphates. J Vis Exp (2011) 0.87
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. J Biol Chem (2002) 2.02
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J (2004) 1.77
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. Curr Biol (2002) 1.69
An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol (2008) 1.62
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains. Biochem J (2013) 1.55
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem (2007) 1.52
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem (2008) 1.44
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. J Biol Chem (2002) 1.37
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat Chem Biol (2011) 1.33
Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia. J Biol Chem (2005) 1.21
Differential redox regulation within the PTP superfamily. Cell Signal (2007) 1.15
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stress. J Biol Chem (2004) 1.13
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc Natl Acad Sci U S A (2008) 1.07
Integration of inositol phosphate signaling pathways via human ITPK1. J Biol Chem (2007) 1.01
Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci (2012) 0.98
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. J Biol Chem (2003) 0.98
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol Pharmacol (2008) 0.98
Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase. Biochem J (2007) 0.95
The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates. J Virol (2002) 0.93
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochem (2002) 0.93
scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications. Chembiochem (2006) 0.93
Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility. Nucleic Acids Res (2004) 0.93
Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. Cell Signal (2005) 0.92
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem Commun (Camb) (2012) 0.92
Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential. J Biol Chem (2002) 0.92
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Biochem J (2011) 0.92
Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J Cell Sci (2006) 0.92
Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation. Angew Chem Int Ed Engl (2014) 0.90
The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J Biol Chem (2008) 0.88
Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha. ACS Chem Biol (2007) 0.87
Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha. Chembiochem (2008) 0.86
Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis". J Biotechnol (2006) 0.86
The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase. Biochem J (2005) 0.84
Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool. Cell Signal (2005) 0.83
Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension (2012) 0.83
Structural insight into inositol pyrophosphate turnover. Adv Biol Regul (2012) 0.82
Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration. J Biol Chem (2003) 0.82
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. Biochem J (2003) 0.81
On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Lett (2005) 0.81
Assembly of mutations for improving thermostability of Escherichia coli AppA2 phytase. Appl Microbiol Biotechnol (2008) 0.80
A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci (2012) 0.80
Defining signal transduction by inositol phosphates. Subcell Biochem (2012) 0.79
The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase. Exp Cell Res (2003) 0.78
Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS Lett (2008) 0.78
Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster. Int J Biochem Cell Biol (2007) 0.78
Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals. FEBS Lett (2006) 0.77
Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein. Free Radic Biol Med (2011) 0.77
Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1. Biochem J (2012) 0.75
Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch? Int J Biochem Cell Biol (2010) 0.75
Synthetic tools for studying the chemical biology of InsP8. Chem Commun (Camb) (2015) 0.75
Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. PLoS One (2017) 0.75