Suicide and the polyamine system.

PubWeight™: 0.82‹?›

🔗 View Article (PMID 24040803)

Published in CNS Neurol Disord Drug Targets on November 01, 2013

Authors

Jeffrey A Gross1, Gustavo Turecki

Author Affiliations

1: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 boul. Lasalle, Verdun, Quebec, H4H 1R3, Canada. gustavo.turecki@mcgill.ca.

Articles cited by this

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82

Polyamines. Annu Rev Biochem (1984) 12.92

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci (2009) 10.17

Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81

Suicide and suicidal behavior. Epidemiol Rev (2008) 6.40

Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry (2005) 2.54

Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res (2011) 2.53

S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry (2010) 2.52

Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One (2008) 2.40

Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry (2006) 2.13

Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry (2012) 2.13

Suicide and mental disorders: a case-control study of young men. Am J Psychiatry (1994) 2.10

Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry (2004) 2.02

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat Neurosci (2010) 1.87

Distribution of 5-hydroxymethylcytosine in different human tissues. J Nucleic Acids (2011) 1.82

Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry (2007) 1.47

Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. PLoS One (2011) 1.45

Modulation and block of ion channels: a new biology of polyamines. Cell Signal (1997) 1.40

Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci (2000) 1.39

Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J (2004) 1.32

Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours. J Psychiatry Neurosci (2005) 1.27

The neurodevelopmental origins of suicidal behavior. Trends Neurosci (2011) 1.26

Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J (1996) 1.24

Hypothesis: environmental regulation of 5-hydroxymethylcytosine by oxidative stress. Epigenetics (2011) 1.22

Stress-induced changes in primate prefrontal profiles of gene expression. Mol Psychiatry (2007) 1.18

Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry (2005) 1.17

Altered gene expression of histone deacetylases in mood disorder patients. J Psychiatr Res (2009) 1.14

Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Nature (2011) 1.11

Suicide neurobiology. Prog Neurobiol (2009) 1.11

Regional localization of agmatine in the rat brain: an immunocytochemical study. Brain Res (1998) 1.06

Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Biochem J (2001) 1.03

Implication of the polyamine system in mental disorders. J Psychiatry Neurosci (2008) 0.97

Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet (2009) 0.95

Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res (2002) 0.95

Global gene expression profiling of the polyamine system in suicide completers. Int J Neuropsychopharmacol (2011) 0.95

Polyamines in neurotrauma. Ubiquitous molecules in search of a function. Biochem Pharmacol (1992) 0.95

Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet (2009) 0.94

Epigenomics: Methylation matters. Nature (2009) 0.94

Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J (2004) 0.93

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. Am J Physiol Endocrinol Metab (2006) 0.93

Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival. Cell Mol Neurobiol (2003) 0.92

Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault. Mol Psychiatry (2012) 0.89

Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. J Neurochem (2006) 0.87

A quantitative GC-MS method for three major polyamines in postmortem brain cortex. J Mass Spectrom (2009) 0.87

Identification and characterization of spermidine/spermine N1-acetyltransferase promoter variants in suicide completers. Biol Psychiatry (2009) 0.86

Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. Prog Neuropsychopharmacol Biol Psychiatry (2006) 0.86

Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. J Neural Transm (Vienna) (2008) 0.86

Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in suicide. J Psychiatr Res (2011) 0.85

Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide. Int J Neuropsychopharmacol (2011) 0.85

Agmatine crosses the blood-brain barrier. Ann N Y Acad Sci (2003) 0.85

Evidence of altered polyamine concentrations in cerebral cortex of suicide completers. Neuropsychopharmacology (2010) 0.84

Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Neuroreport (2001) 0.83

Antidepressant-like effect of agmatine and its possible mechanism. Eur J Pharmacol (2003) 0.82

Chronic lithium treatment prevents the dexamethasone-induced increase of brain polyamine metabolizing enzymes. Life Sci (1992) 0.82

Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers. Int J Neuropsychopharmacol (2010) 0.81

Anxiolytic effect of agmatine in rats and mice. Eur J Pharmacol (2006) 0.81

Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology (2009) 0.81

Polyamines and their metabolizing enzymes in human frontal cortex and hippocampus: preliminary measurements in affective disorders. Biol Psychiatry (1995) 0.81

The hunt for 5-hydroxymethylcytosine: the sixth base. Epigenomics (2011) 0.81

Polyamine metabolism and function in brain. Neurochem Int (1981) 0.81

Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation. J Neurosci Res (2008) 0.80

Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain Res (2002) 0.80

Association of the SAT1 in/del polymorphism with suicide completion. Am J Med Genet B Neuropsychiatr Genet (2010) 0.79

Spermine interacts with cocaine binding sites on dopamine transporters. Psychopharmacology (Berl) (1994) 0.79

Polyamines modulate the binding of GABAA-benzodiazepine receptor ligands in membranes from the rat forebrain. Neuropharmacology (1992) 0.78

Nitric oxide, free radicals and polyamines may have a role in the membrane pathology of schizophrenia. Neuropsychobiology (1998) 0.78

Passage of spermidine across the blood-brain barrier in short recirculation periods following global cerebral ischemia: effects of mild hyperthermia. Neurosci Res (2002) 0.78

Polyamine-modulated factor 1 represses glucocorticoid receptor activity. Biochem Biophys Res Commun (2007) 0.76

A novel liquid-liquid extraction and stable isotope dilution NCI-GC-MS method for quantitation of agmatine in postmortem brain cortex. J Mass Spectrom (2010) 0.76

High-resolution capillary gas chromatography in combination with mass spectrometry for quantification of three major polyamines in postmortem brain cortex. Methods Mol Biol (2011) 0.76

Lithium exerts a time-dependent and tissue-selective attenuation of the dexamethasone-induced polyamine response in rat brain and liver. Brain Res (1994) 0.75

Articles by these authors

(truncated to the top 100)

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci (2009) 10.17

Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet (2007) 4.54

International Society for Bipolar Disorders Task Force on Suicide: meta-analyses and meta-regression of correlates of suicide attempts and suicide deaths in bipolar disorder. Bipolar Disord (2014) 4.10

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet (2003) 3.02

Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci (2003) 2.67

Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry (2005) 2.54

Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One (2008) 2.40

Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry (2012) 2.13

Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry (2006) 2.13

Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry (2004) 2.02

Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. Am J Psychiatry (2009) 1.95

Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry (2011) 1.92

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet (2008) 1.78

Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One (2009) 1.78

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat Med (2013) 1.70

Risk factors for suicide completion in borderline personality disorder: a case-control study of cluster B comorbidity and impulsive aggression. J Clin Psychiatry (2007) 1.58

Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry (2012) 1.57

Diagnosing zygosity in infant twins: physical similarity, genotyping, and chorionicity. Twin Res (2003) 1.56

Sexual orientation and gender identity in youth suicide victims: an exploratory study. Can J Psychiatry (2010) 1.54

The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases. PLoS One (2013) 1.51

Psychiatric risk factors for motor vehicle fatalities in young men. Can J Psychiatry (2005) 1.48

Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proc Natl Acad Sci U S A (2012) 1.45

Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology (2012) 1.45

An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: a psychological autopsy study. J Affect Disord (2006) 1.44

Is violent method of suicide a behavioral marker of lifetime aggression? Am J Psychiatry (2005) 1.42

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biol (2014) 1.37

Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci (2013) 1.35

Genome wide gene expression studies in mood disorders. OMICS (2006) 1.35

Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry (2009) 1.31

Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry (2008) 1.28

Suicidality and risk of suicide--definition, drug safety concerns, and a necessary target for drug development: a consensus statement. J Clin Psychiatry (2010) 1.27

MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One (2012) 1.25

Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry (2013) 1.25

Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods. Can J Psychiatry (2007) 1.23

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. Hum Mol Genet (2009) 1.21

The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. J Clin Psychiatry (2010) 1.21

Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One (2012) 1.20

A deletion in tropomyosin-related kinase B and the development of human anxiety. Biol Psychiatry (2010) 1.19

Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. CMAJ (2011) 1.18

The relationship of impulsive aggressiveness to suicidality and other depression-linked behaviors. Curr Psychiatry Rep (2007) 1.18

Life trajectories and burden of adversity: mapping the developmental profiles of suicide mortality. Psychol Med (2007) 1.17

Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. J Psychiatr Res (2009) 1.17

Characterization of impulsivity in suicide completers: clinical, behavioral and psychosocial dimensions. J Affect Disord (2006) 1.15

The genetics of suicide: a critical review of molecular studies. Psychiatr Clin North Am (2008) 1.15

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies. J Neurosci Methods (2008) 1.15

Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology (2011) 1.14

Suicide neurobiology. Prog Neurobiol (2009) 1.11

Alcohol and cigarette use and misuse among Hurricane Katrina survivors: psychosocial risk and protective factors. Subst Use Misuse (2009) 1.10

Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Ann Neurol (2011) 1.07

Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities. Am J Hum Genet (2012) 1.07

What is the meaning of treatment resistant/refractory major depression (TRD)? A systematic review of current randomized trials. Eur Neuropsychopharmacol (2007) 1.06

Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry (2007) 1.06

Recent and lifetime utilization of health care services by children and adolescent suicide victims: a case-control study. J Affect Disord (2009) 1.04

Morphometric characterization of microglial phenotypes in human cerebral cortex. J Neuroinflammation (2014) 1.04

Current psychiatric morbidity, aggression/impulsivity, and personality dimensions in child and adolescent suicide: a case-control study. J Affect Disord (2007) 1.03

H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression. Int J Neuropsychopharmacol (2012) 1.02

Lithium response and genetic variation in the CREB family of genes. Am J Med Genet B Neuropsychiatr Genet (2008) 1.01

Natural history of suicidal behaviors in a population-based sample of young adults. Psychol Med (2007) 1.01

The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression. Int J Neuropsychopharmacol (2010) 1.00

Cholesterol content in brains of suicide completers. Int J Neuropsychopharmacol (2006) 1.00

Linkage to the CCM2 locus and genetic heterogeneity in familial cerebral cavernous malformation. Can J Neurol Sci (2003) 0.99

Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J Psychiatry Neurosci (2010) 0.98

Suicidality and risk of suicide--definition, drug safety concerns, and a necessary target for drug development: a brief report. J Clin Psychiatry (2010) 0.98

Systematic services audit of consecutive suicides in New Brunswick: the case for coordinating specialist mental health and addiction services. Can J Psychiatry (2008) 0.98

Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol (2005) 0.98

The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology (2010) 0.98

Implication of the polyamine system in mental disorders. J Psychiatry Neurosci (2008) 0.97

What is specific to suicide in schizophrenia disorder? Demographic, clinical and behavioural dimensions. Schizophr Res (2007) 0.96

Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.95

Fatty acid composition in postmortem brains of people who completed suicide. J Psychiatry Neurosci (2007) 0.95

Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses. Int J Neuropsychopharmacol (2010) 0.95

Global gene expression profiling of the polyamine system in suicide completers. Int J Neuropsychopharmacol (2011) 0.95

Personality traits as correlates of suicide attempts and suicidal ideation in young adults. Psychol Med (2005) 0.95

Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers. PLoS One (2012) 0.95

Identifying correlates of suicide attempts in suicidal ideators: a population-based study. Psychol Med (2007) 0.95

Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet (2009) 0.94

Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse (2006) 0.94

Cross-prevalence of migraine and bipolar disorder. Bipolar Disord (2010) 0.93

Family history of suicidal behavior predicts impulsive-aggressive behavior levels in psychiatric outpatients. J Affect Disord (2008) 0.93

Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse. Int J Eat Disord (2013) 0.92

STin2 variant and family history of suicide as significant predictors of suicide completion in major depression. Biol Psychiatry (2005) 0.92

Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder. J Psychiatry Neurosci (2013) 0.92

Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. Biol Psychiatry (2009) 0.92

The epigenetics of suicide: explaining the biological effects of early life environmental adversity. Arch Suicide Res (2010) 0.91

Confirmation of region-specific patterns of gene expression in the human brain. Neurogenetics (2007) 0.91

Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. Am J Med Genet B Neuropsychiatr Genet (2003) 0.90

SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. Neurochem Int (2012) 0.90

Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior. Am J Med Genet B Neuropsychiatr Genet (2003) 0.89

The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide. Am J Med Genet B Neuropsychiatr Genet (2007) 0.89

Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder. PLoS One (2012) 0.89

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Am J Med Genet B Neuropsychiatr Genet (2008) 0.89

The 14q restless legs syndrome locus in the French Canadian population. Ann Neurol (2004) 0.89

Cholesterol metabolism and suicidality in Smith-Lemli-Opitz syndrome carriers. Am J Psychiatry (2004) 0.89

Suicide and no axis I psychopathology. BMC Psychiatry (2004) 0.88

Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. Int J Neuropsychopharmacol (2013) 0.88

Childhood trajectories of anxiousness and disruptiveness as predictors of suicide attempts. Arch Pediatr Adolesc Med (2008) 0.88

Seasonal differences in psychopathology of male suicide completers. Compr Psychiatry (2004) 0.88

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One (2013) 0.88

Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide. J Psychiatr Res (2012) 0.87