The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3956710)

Published in Psychopharmacology (Berl) on September 17, 2013

Authors

Melissa Morales1, Linda P Spear

Author Affiliations

1: Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA, mmorales@wakehealth.edu.

Articles cited by this

The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev (2000) 17.59

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44

Oxytocin, vasopressin, and the neurogenetics of sociality. Science (2008) 5.53

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature (1994) 4.92

Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology (1998) 4.56

Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry (2007) 3.13

A review of 25 years of the social interaction test. Eur J Pharmacol (2003) 2.74

Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res (1998) 2.60

Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin Exp Res (2002) 2.53

Can social interaction be used to measure anxiety? Br J Pharmacol (1978) 2.50

The neurobiology of social play behavior in rats. Neurosci Biobehav Rev (1997) 2.46

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Brain Res Rev (1990) 2.27

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods (1980) 2.26

Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J Neurosci (2005) 2.19

Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci (2006) 2.16

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem (1997) 2.14

Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice. Neurotoxicol Teratol (2012) 2.12

Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development. J Neurosci (2004) 2.11

Regulation of anxiety by GABAA receptors in the rat amygdala. Pharmacol Biochem Behav (1995) 1.85

The ecology of adolescent activity and experience. J Youth Adolesc (1977) 1.74

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission. Mol Pharmacol (2006) 1.59

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. Alcohol (2004) 1.59

Differences in the social consequences of ethanol emerge during the course of adolescence in rats: social facilitation, social inhibition, and anxiolysis. Dev Psychobiol (2006) 1.56

Social interactions in adolescent and adult Sprague-Dawley rats: impact of social deprivation and test context familiarity. Behav Brain Res (2007) 1.52

Social behavior and social motivation in adolescent rats: role of housing conditions and partner's activity. Physiol Behav (1999) 1.52

Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B synapses in the adult central amygdala. J Neurosci (2003) 1.43

Nucleus accumbens μ-opioid receptors mediate social reward. J Neurosci (2011) 1.39

Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. Psychopharmacology (Berl) (2008) 1.28

Ethanol sensitivity of NMDA receptors. Neurochem Int (2002) 1.22

Ethanol-induced conditioned taste aversion in male sprague-dawley rats: impact of age and stress. Alcohol Clin Exp Res (2010) 1.21

Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants. Neuropharmacology (1995) 1.20

Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity. Toxicol Sci (2002) 1.15

Repeated restraint stress alters sensitivity to the social consequences of ethanol in adolescent and adult rats. Pharmacol Biochem Behav (2010) 1.14

(+)-MK-801 induced social withdrawal in rats; a model for negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry (2005) 1.10

The effects of NMDA and GABAA pharmacological manipulations on ethanol sensitivity in immature and mature animals. Alcohol Clin Exp Res (2002) 1.09

Anxiolytic effects of chlordiazepoxide blocked by injection of GABAA and benzodiazepine receptor antagonists in the region of the anterior basolateral amygdala of rats. Biol Psychiatry (1995) 1.09

Ethanol-induced social facilitation in adolescent rats: role of endogenous activity at mu opioid receptors. Alcohol Clin Exp Res (2009) 1.06

Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats. Pharmacol Biochem Behav (2011) 1.04

Sex differences in N-methyl-D-aspartate involvement in kappa opioid and non-opioid predator-induced analgesia in mice. Brain Res (1997) 1.03

Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats. Eur J Pharmacol (1995) 1.03

Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking. Alcohol Clin Exp Res (2010) 1.02

Social interactions and 50 kHz ultrasonic vocalizations in adolescent and adult rats. Behav Brain Res (2009) 1.01

Acute effects of ketamine in the holeboard, the elevated-plus maze, and the social interaction test in Wistar rats. Depress Anxiety (1997) 1.01

Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Prog Neuropsychopharmacol Biol Psychiatry (2009) 0.98

Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. Behav Brain Res (2012) 0.97

The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats. Exp Neurol (2006) 0.96

Adolescent C57BL/6J mice show elevated alcohol intake, but reduced taste aversion, as compared to adult mice: a potential behavioral mechanism for binge drinking. Alcohol Clin Exp Res (2011) 0.95

Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations. Psychopharmacology (Berl) (1984) 0.95

Ontogeny of ethanol-induced motor impairment following acute ethanol: assessment via the negative geotaxis reflex in adolescent and adult rats. Pharmacol Biochem Behav (2010) 0.95

Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. Synapse (2009) 0.93

Locomotion elicited by MK801 in developing and adult rats: temporal, environmental, and gender effects. Eur J Pharmacol (1999) 0.88

Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia. Behav Brain Res (2011) 0.88

Effects of MK-801 on rough-and-tumble play in juvenile rats. Physiol Behav (1995) 0.88

Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behav Brain Res (2013) 0.87

genetic overexpression of NR2B subunit enhances social recognition memory for different strains and species. PLoS One (2012) 0.87

Improvement of phencyclidine-induced social behaviour deficits in rats: involvement of 5-HT1A receptors. Behav Brain Res (2008) 0.87

NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci (2012) 0.86

The putative antipsychotic alstonine reverses social interaction withdrawal in mice. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.84

Effect of antemortem and postmortem factors on [3H]glutamate binding in the human brain. Neurosci Lett (1988) 0.84

Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. Alcohol Clin Exp Res (2011) 0.84

Age differences in the expression of acute and chronic tolerance to ethanol in male and female rats. Alcohol Clin Exp Res (2011) 0.84

D-Cycloserine improves the impaired sociability of the Balb/c mouse. Brain Res Bull (2010) 0.78

Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine. Eur J Pharmacol (1998) 0.78

D-Cycloserine enhances social exploration in the Balb/c mouse. Brain Res Bull (2011) 0.77

Impaired social motivation and increased aggression in rats subchronically exposed to phencyclidine. Physiol Behav (2008) 0.77

Articles by these authors

Transitions into underage and problem drinking: developmental processes and mechanisms between 10 and 15 years of age. Pediatrics (2008) 2.96

Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin Exp Res (2002) 2.53

Factors influencing elevated ethanol consumption in adolescent relative to adult rats. Alcohol Clin Exp Res (2005) 2.43

Underage drinking: a developmental framework. Pediatrics (2008) 2.30

Rewarding properties of social interactions in adolescent and adult male and female rats: impact of social versus isolate housing of subjects and partners. Dev Psychobiol (2004) 2.02

Time course of elevated ethanol intake in adolescent relative to adult rats under continuous, voluntary-access conditions. Alcohol Clin Exp Res (2007) 1.98

Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn (2009) 1.96

Nicotine-induced conditioned place preference in adolescent and adult rats. Physiol Behav (2002) 1.84

Effect of stress on the voluntary intake of a sweetened ethanol solution in pair-housed adolescent and adult rats. Alcohol Clin Exp Res (2005) 1.69

Differences in the social consequences of ethanol emerge during the course of adolescence in rats: social facilitation, social inhibition, and anxiolysis. Dev Psychobiol (2006) 1.56

Social interactions in adolescent and adult Sprague-Dawley rats: impact of social deprivation and test context familiarity. Behav Brain Res (2007) 1.52

Novel-object place conditioning in adolescent and adult male and female rats: effects of social isolation. Physiol Behav (2003) 1.44

Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female Sprague-Dawley rats. Alcohol Clin Exp Res (2004) 1.41

A developmental perspective on underage alcohol use. Alcohol Res Health (2009) 1.36

Ontogeny of acute tolerance to ethanol-induced social inhibition in Sprague-Dawley rats. Alcohol Clin Exp Res (2006) 1.32

Social and non-social anxiety in adolescent and adult rats after repeated restraint. Physiol Behav (2009) 1.30

Changes in sensitivity to ethanol-induced social facilitation and social inhibition from early to late adolescence. Ann N Y Acad Sci (2004) 1.24

Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models. Alcohol Clin Exp Res (2005) 1.24

Ethanol-induced conditioned taste aversion in male sprague-dawley rats: impact of age and stress. Alcohol Clin Exp Res (2010) 1.21

Adolescent and adult rats' aversion to flavors previously paired with nicotine. Ann N Y Acad Sci (2004) 1.20

Hedonic sensitivity in adolescent and adult rats: taste reactivity and voluntary sucrose consumption. Pharmacol Biochem Behav (2009) 1.18

Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats. Neurotoxicol Teratol (2006) 1.14

Repeated restraint stress alters sensitivity to the social consequences of ethanol in adolescent and adult rats. Pharmacol Biochem Behav (2010) 1.14

Hormonal and physical markers of puberty and their relationship to adolescent-typical novelty-directed behavior. Dev Psychobiol (2011) 1.11

Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcohol Clin Exp Res (2011) 1.07

Transitions into underage and problem drinking: summary of developmental processes and mechanisms: ages 10-15. Alcohol Res Health (2009) 1.06

Ethanol-induced social facilitation in adolescent rats: role of endogenous activity at mu opioid receptors. Alcohol Clin Exp Res (2009) 1.06

Increases in anxiety-like behavior induced by acute stress are reversed by ethanol in adolescent but not adult rats. Pharmacol Biochem Behav (2011) 1.04

Withdrawal from chronic nicotine in adolescent and adult rats. Pharmacol Biochem Behav (2006) 1.03

Sensitivity and tolerance to autonomic effects of ethanol in adolescent and adult rats during repeated vapor inhalation sessions. Alcohol Clin Exp Res (2005) 1.02

Social interactions and 50 kHz ultrasonic vocalizations in adolescent and adult rats. Behav Brain Res (2009) 1.01

The International society for developmental psychobiology 39th annual meeting symposium: Alcohol and development: beyond fetal alcohol syndrome. Dev Psychobiol (2007) 1.01

Factor analysis of elevated plus-maze behavior in adolescent and adult rats. Pharmacol Biochem Behav (2006) 0.98

The effects of gonadectomy on age- and sex-typical patterns of ethanol consumption in Sprague-Dawley rats. Alcohol Clin Exp Res (2011) 0.97

Developmental differences in acute ethanol withdrawal in adolescent and adult rats. Alcohol Clin Exp Res (2007) 0.97

Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood. Behav Brain Res (2013) 0.96

Sensitization to social anxiolytic effects of ethanol in adolescent and adult Sprague-Dawley rats after repeated ethanol exposure. Alcohol (2010) 0.95

Integrating field methodology and web-based data collection to assess the reliability of the Alcohol Use Disorders Identification Test (AUDIT). Drug Alcohol Depend (2011) 0.95

Amphetamine-induced incentive sensitization of sign-tracking behavior in adolescent and adult female rats. Behav Neurosci (2011) 0.95

Adolescent and adult heart rate responses to self-administered ethanol. Alcohol Clin Exp Res (2008) 0.94

Age-related differences in impulsivity among adolescent and adult Sprague-Dawley rats. Behav Neurosci (2012) 0.92

Differential expression of ethanol-induced hypothermia in adolescent and adult rats induced by pretest familiarization to the handling/injection procedure. Alcohol Clin Exp Res (2007) 0.92

Autonomic responses to ethanol in adolescent and adult rats: a dose-response analysis. Alcohol (2008) 0.92

Acute and chronic effects of alcohol on trail making test performance among underage drinkers in a field setting. J Stud Alcohol Drugs (2013) 0.91

Autoshaping in adolescence enhances sign-tracking behavior in adulthood: impact on ethanol consumption. Pharmacol Biochem Behav (2011) 0.90

Effects of voluntary access to sweetened ethanol during adolescence on intake in adulthood. Alcohol Clin Exp Res (2012) 0.89

Developmental differences in temporal patterns and potentiation of isolation-induced ultrasonic vocalizations: influence of temperature variables. Dev Psychobiol (2002) 0.88

The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats. Behav Brain Res (2011) 0.88

Evidence for suppressant effects of testosterone on sex-typical ethanol intake in male Sprague-Dawley rats. Behav Brain Res (2011) 0.88

Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behav Brain Res (2013) 0.87

The alcoholism generator. Alcohol Clin Exp Res (2006) 0.86

Differences in sensitivity to ethanol-induced conditioned taste aversions emerge after pre- or post-pubertal gonadectomy in male and female rats. Behav Brain Res (2012) 0.85

Development of anticipatory 50 kHz USV production to a social stimuli in adolescent and adult male Sprague-Dawley rats. Behav Brain Res (2011) 0.85

Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure. Dev Neurosci (2014) 0.85

Age differences in fear retention and extinction in male Sprague-Dawley rats: effects of ethanol challenge during conditioning. Behav Brain Res (2013) 0.84

Different chronic ethanol exposure regimens in adolescent and adult male rats: effects on tolerance to ethanol-induced motor impairment. Behav Brain Res (2011) 0.84

Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. Alcohol Clin Exp Res (2011) 0.84

Age differences in the expression of acute and chronic tolerance to ethanol in male and female rats. Alcohol Clin Exp Res (2011) 0.84

Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl) (2013) 0.83

Gender, history of alcohol use and number of drinks consumed predict craving among drinkers in a field setting. Addict Behav (2013) 0.82

Environmental manipulations alter age differences in attribution of incentive salience to reward-paired cues. Behav Brain Res (2013) 0.82

Ethanol intake under social circumstances or alone in sprague-dawley rats: impact of age, sex, social activity, and social anxiety-like behavior. Alcohol Clin Exp Res (2015) 0.82

Puberty and gonadal hormones: role in adolescent-typical behavioral alterations. Horm Behav (2013) 0.81

Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress. Pharmacol Biochem Behav (2013) 0.81

Are we drunk yet? Motor versus cognitive cues of subjective intoxication. Alcohol Clin Exp Res (2013) 0.80

Social context induces two unique patterns of c-Fos expression in adolescent and adult rats. Dev Psychobiol (2012) 0.80

Tone conditioning potentiates rather than overshadows context fear in adult animals following adolescent ethanol exposure. Dev Psychobiol (2013) 0.79

Effects of ethanol on social approach and 50 kHz ultrasonic vocalization production in adolescent male Sprague-Dawley rats. Dev Psychobiol (2013) 0.79

The effects of pre-test social deprivation on a natural reward incentive test and concomitant 50 kHz ultrasonic vocalization production in adolescent and adult male Sprague-Dawley rats. Behav Brain Res (2013) 0.79

Age-related differences in amphetamine sensitization: effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats. Pharmacol Biochem Behav (2010) 0.79

Consequences of adolescent or adult ethanol exposure on tone and context fear retention: effects of an acute ethanol challenge during conditioning. Alcohol Clin Exp Res (2014) 0.78

Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. Dev Psychobiol (2013) 0.78

Repeated restraint stress alters sensitivity to the social consequences of ethanol differentially in early and late adolescent rats. Pharmacol Biochem Behav (2013) 0.78

Age differences in ethanol discrimination: acquisition and ethanol dose generalization curves following multiple training conditions in adolescent and adult rats. Alcohol Clin Exp Res (2013) 0.78

Age-dependent effects of stress on ethanol-induced motor activity in rats. Psychopharmacology (Berl) (2013) 0.77

Ethanol reduces evoked dopamine release and slows clearance in the rat medial prefrontal cortex. Alcohol Clin Exp Res (2014) 0.77

Adolescent binge-like alcohol alters sensitivity to acute alcohol effects on dopamine release in the nucleus accumbens of adult rats. Psychopharmacology (Berl) (2016) 0.76

Effects of acute ethanol administration and chronic stress exposure on social investigation and 50kHz ultrasonic vocalizations in adolescent and adult male Sprague-Dawley rats. Pharmacol Biochem Behav (2013) 0.75