Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3776760)

Published in PLoS One on September 18, 2013

Authors

Xiaoping Yang1, Francisco G La Rosa, Elizabeth Erin Genova, Kendra Huber, Jerome Schaack, James Degregori, Natalie J Serkova, Yuan Li, Lih-Jen Su, Elizabeth Kessler, Thomas W Flaig

Author Affiliations

1: Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; University of Colorado Cancer Center, Aurora, Colorado, United States of America.

Articles cited by this

Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63

Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13

Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87

Lung cancer. N Engl J Med (2008) 13.49

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature (2001) 10.56

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36

Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science (2010) 6.67

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14

Maximizing mouse cancer models. Nat Rev Cancer (2007) 5.38

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc (2009) 4.50

A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96

Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res (1997) 3.70

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell (2003) 3.31

Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev (2009) 2.99

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest (2012) 2.95

The mammalian urinary bladder: an accommodating organ. Biol Rev Camb Philos Soc (1975) 2.71

Conditional mouse models of sporadic cancer. Nat Rev Cancer (2002) 2.47

A simple method for the rapid generation of recombinant adenovirus vectors. Gene Ther (2000) 2.34

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium. Urol Oncol (2010) 2.16

Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res (2012) 2.14

An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest (2012) 2.13

Clinical model of lifetime cost of treating bladder cancer and associated complications. Urology (2006) 1.72

Cre/loxP recombination system and gene targeting. Methods Mol Biol (2002) 1.64

Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res (2009) 1.37

Development of stable liquid formulations for adenovirus-based vaccines. J Pharm Sci (2004) 1.26

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene (2010) 1.20

Proliferation markers. Exp Toxicol Pathol (1996) 1.18

Mouse orthotopic models for bladder cancer research. BJU Int (2009) 1.17

Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol (2004) 1.16

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death Dis (2011) 1.15

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis. Cancer Res (2009) 1.13

Molecular alterations in bladder cancer. Urol Res (1998) 1.09

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech (2011) 1.08

Gene deletion in urothelium by specific expression of Cre recombinase. Am J Physiol Renal Physiol (2005) 1.06

E1A and E1B proteins inhibit inflammation induced by adenovirus. Proc Natl Acad Sci U S A (2004) 1.03

p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis. Oncogene (2004) 1.01

The spectrum of TP53 mutations in bladder carcinoma. Genes Chromosomes Cancer (1994) 0.99

Multiple functions encoded by the N-terminal PAT domain of adipophilin. J Cell Sci (2008) 0.99

Low-frequency mutation of Ha-ras and Ki-ras oncogenes in transitional cell carcinoma of the bladder. Anticancer Res (1998) 0.97

Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. Mediators Inflamm (2012) 0.95

p53 mutations and prognosis in bladder tumors. J Urol (1995) 0.91

Molecular genetics of bladder cancer. Br J Urol (1995) 0.89

Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors. Urol Int (1995) 0.85

K-RAS mutation in transitional cell carcinoma of urinary bladder. Int Urol Nephrol (2001) 0.84

Novel targeted agents for the treatment of bladder cancer: translating laboratory advances into clinical application. Int Braz J Urol (2010) 0.79

Controlling gene expression in the urothelium using transgenic mice with inducible bladder specific Cre-lox recombination. J Urol (2002) 0.78

Development of a conditional mouse model for head and neck squamous cell carcinoma. Adv Otorhinolaryngol (2005) 0.76

Bladder tumours: time for a paradigm shift? BJU Int (2011) 0.76

Articles by these authors

Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med (2011) 27.58

Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med (2012) 20.79

Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med (2012) 15.69

Transcription start regions in the human genome are favored targets for MLV integration. Science (2003) 12.21

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A (2006) 6.82

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial. J Natl Cancer Inst (2007) 4.64

Extracellular-matrix tethering regulates stem-cell fate. Nat Mater (2012) 3.94

RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol (2012) 3.72

Immune clearance of highly pathogenic SIV infection. Nature (2013) 3.15

Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02

Clinical applications of metabolomics in oncology: a review. Clin Cancer Res (2009) 2.91

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res (2004) 2.79

Adjuvant androgen deprivation for high-risk prostate cancer after radical prostatectomy: SWOG S9921 study. J Clin Oncol (2011) 2.57

The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55

Pathologic characteristics of cancers detected in The Prostate Cancer Prevention Trial: implications for prostate cancer detection and chemoprevention. Cancer Prev Res (Phila) (2008) 2.43

Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol (2010) 2.41

Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J Virol (2005) 2.29

Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. Kidney Int (2011) 2.20

Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res (2012) 2.14

Targeted therapy in advanced urothelial carcinoma. Oncology (Williston Park) (2013) 2.07

A renaissance in the medical treatment of advanced prostate cancer. Oncology (Williston Park) (2010) 2.05

A rare case of metastatic renal epithelioid angiomyolipoma. Oncology (Williston Park) (2011) 2.02

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med (2006) 2.01

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99

Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology (2006) 1.96

Coordination dynamics of zinc in proteins. Chem Rev (2009) 1.95

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J Biol Chem (2005) 1.94

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther (2004) 1.88

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Nat Med (2012) 1.86

Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology (2006) 1.80

The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.78

Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res (2012) 1.77

Uncommon adrenal masses: CT and MRI features with histopathologic correlation. Eur J Radiol (2007) 1.73

Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses. J Virol (2007) 1.69

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A (2011) 1.66

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell (2010) 1.64

Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis. J Biol Chem (2008) 1.64

A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs (2006) 1.63

Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol Genomics (2006) 1.61

Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution. J Bone Joint Surg Am (2012) 1.58

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am J Pathol (2006) 1.57

Triage of pediatric injuries after the 2008 Wen-Chuan earthquake in China. J Pediatr Surg (2009) 1.50

Optimizing outcomes of advanced prostate cancer: drug sequencing and novel therapeutic approaches. Oncology (Williston Park) (2012) 1.49

Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts. Endocrinology (2012) 1.48

Biochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha protein. J Virol (2008) 1.48

A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases. Plant Cell (2010) 1.48

C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes (2005) 1.48

Multi-scale numerical simulations on piezoresistivity of CNT/polymer nanocomposites. Nanoscale Res Lett (2012) 1.45

Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lung. J Immunol (2009) 1.45

The role of matrix metalloproteinase-2 in the treatment of atrial fibrillation recurrence after a radiofrequency modified maze procedure. Cardiology (2013) 1.43

Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis. Plant Cell (2010) 1.42

Correlation of SATB1 overexpression with the progression of human rectal cancer. Int J Colorectal Dis (2011) 1.40

The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer. J Gastroenterol (2013) 1.40

Retracted Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. Cancer Sci (2014) 1.39

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics (2006) 1.38

Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. J Virol (2006) 1.38

Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J (2004) 1.36

Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab (2010) 1.36

Unique features of TRIM5alpha among closely related human TRIM family members. Virology (2006) 1.33

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res (2009) 1.33

Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines. Hepatology (2005) 1.31

A clinical study of 674 patients with oral lichen planus in China. J Oral Pathol Med (2005) 1.30

Simian immunodeficiency virus integration preference is similar to that of human immunodeficiency virus type 1. J Virol (2005) 1.30

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1. J Immunol (2009) 1.27

Clinical opportunities and challenges in targeting tumour dormancy. Nat Rev Clin Oncol (2012) 1.26

3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen. J Biomol Screen (2011) 1.24

Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Investig Med (2002) 1.23

Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ¹H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol (2010) 1.21

The use of quantitative real-time reverse transcriptase PCR for 5' and 3' portions of ALK transcripts to detect ALK rearrangements in lung cancers. Clin Cancer Res (2012) 1.21

Lipid droplet targeting domains of adipophilin. J Lipid Res (2003) 1.20

Survivin expression quantified by Image Pro-Plus compared with visual assessment. Appl Immunohistochem Mol Morphol (2009) 1.19

Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer. Tumour Biol (2013) 1.19

Enzymatically amplified surface plasmon resonance imaging detection of DNA by exonuclease III digestion of DNA microarrays. Anal Chem (2005) 1.19

Clinical-pathologic correlation between transperineal mapping biopsies of the prostate and three-dimensional reconstruction of prostatectomy specimens. Prostate (2012) 1.18

A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate (2010) 1.18

Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease. Lung Cancer (2008) 1.17

Addison's disease due to adrenal tuberculosis: contrast-enhanced CT features and clinical duration correlation. Eur J Radiol (2006) 1.17

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A (2011) 1.16

Glutathione-indole-3-acetonitrile is required for camalexin biosynthesis in Arabidopsis thaliana. Plant Cell (2011) 1.15

Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. Mol Cancer Res (2007) 1.14

Transfer of plastid DNA to the nucleus is elevated during male gametogenesis in tobacco. Plant Physiol (2008) 1.14

Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures. PLoS One (2009) 1.13

Signal transducer and activator of transcription 3 (Stat3C) promotes myeloid-derived suppressor cell expansion and immune suppression during lung tumorigenesis. Am J Pathol (2011) 1.13

[Study on the current status and trend of food consumption among Chinese population]. Zhonghua Liu Xing Bing Xue Za Zhi (2005) 1.13

Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose. Lung Cancer (2012) 1.12

Digital quantification of five high-grade prostate cancer patterns, including the cribriform pattern, and their association with adverse outcome. Am J Clin Pathol (2011) 1.11

Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol (2009) 1.11

The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res (2013) 1.11

Alcohol potentiates hepatitis C virus replicon expression. Hepatology (2003) 1.11

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc Natl Acad Sci U S A (2013) 1.11

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer. Gut Liver (2011) 1.11

Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes (2011) 1.10