Polyphenols: benefits to the cardiovascular system in health and in aging.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 3820045)

Published in Nutrients on September 26, 2013

Authors

Sandhya Khurana1, Krishnan Venkataraman, Amanda Hollingsworth, Matthew Piche, T C Tai

Author Affiliations

1: Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada. tc.tai@nosm.ca.

Associated clinical trials:

Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain | NCT03372109

Articles citing this

Resources and biological activities of natural polyphenols. Nutrients (2014) 1.17

Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. Dis Markers (2013) 1.16

Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients (2016) 0.93

Dietary polyphenols in prevention and treatment of prostate cancer. Int J Mol Sci (2015) 0.89

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases. Front Pharmacol (2016) 0.86

Organic anion-transporting polypeptides. Curr Top Membr (2014) 0.84

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients (2016) 0.83

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis Res Ther (2014) 0.82

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways. PLoS One (2016) 0.81

The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress. Oxid Med Cell Longev (2015) 0.79

Hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and AIDS. Front Nutr (2014) 0.79

Pomegranate Juice Enhances Healthy Lifespan in Drosophila melanogaster: An Exploratory Study. Front Public Health (2014) 0.78

Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biol Open (2015) 0.78

Suppressive effect of epigallocatechin-3-O-gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo. J Cell Mol Med (2016) 0.77

Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits. Adv Nutr (2014) 0.77

Grape Seed Oil Compounds: Biological and Chemical Actions for Health. Nutr Metab Insights (2016) 0.77

Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients. Front Pharmacol (2017) 0.76

Modulation of Aromatase by Phytoestrogens. Enzyme Res (2015) 0.76

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats. Mol Cells (2016) 0.76

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study. Drug Des Devel Ther (2015) 0.76

Resveratrol increases nephrin and podocin expression and alleviates renal damage in rats fed a high-fat diet. Nutrients (2014) 0.76

Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk. Healthcare (Basel) (2017) 0.76

Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation. Int J Mol Sci (2017) 0.75

Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study. BMJ Open (2016) 0.75

Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study. Oxid Med Cell Longev (2017) 0.75

Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits. Nutr Metab Insights (2016) 0.75

Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Oxid Med Cell Longev (2015) 0.75

The Potential of Curcumin in Treatment of Spinal Cord Injury. Neurol Res Int (2016) 0.75

Oxidative Tea Polyphenols Greatly Inhibit the Absorption of Atenolol. Front Pharmacol (2016) 0.75

Chronic treatment with epigallocatechin gallate reduces motor hyperactivity and affects in vitro tested intestinal motility of spontaneously hypertensive rats. Food Nutr Res (2016) 0.75

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies. J Transl Med (2016) 0.75

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response? Br J Pharmacol (2017) 0.75

Amino Acid Carbamates As Prodrugs Of Resveratrol. Sci Rep (2015) 0.75

Oxidized epigallocatechin gallate inhibited lysozyme fibrillation more strongly than the native form. Redox Biol (2016) 0.75

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil. PLoS One (2015) 0.75

Resveratrol and Alzheimer's Disease: Mechanistic Insights. Mol Neurobiol (2016) 0.75

Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.75

Articles cited by this

(truncated to the top 100)

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77

Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet (1992) 11.12

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res (2000) 10.95

The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol (2006) 9.61

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev (2000) 8.92

Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57

Polyphenols: food sources and bioavailability. Am J Clin Nutr (2004) 7.46

The mechanisms of action of PPARs. Annu Rev Med (2002) 6.71

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet (1993) 6.53

Circulating microRNAs in patients with coronary artery disease. Circ Res (2010) 6.28

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr (2005) 6.05

Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem (2000) 5.38

Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol (2009) 5.37

Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol (2007) 5.13

Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev (1998) 4.50

Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol (2000) 4.21

Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA (2006) 4.08

Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev (2010) 4.02

Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr (2005) 4.01

Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes (2006) 3.85

Role of oxidative stress in cardiovascular diseases. J Hypertens (2000) 3.73

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol (2008) 3.24

Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation (2008) 3.19

Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation (2002) 3.10

Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr (2006) 3.09

NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care (2008) 3.07

The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med (2006) 3.05

Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature (2005) 2.90

Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65

Polyphenols: antioxidants and beyond. Am J Clin Nutr (2005) 2.59

The chemistry of tea flavonoids. Crit Rev Food Sci Nutr (1997) 2.51

Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res (2000) 2.32

Reactive oxygen species in cardiovascular disease. Free Radic Biol Med (2011) 2.29

Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology (2002) 2.28

Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr (2012) 2.24

Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am J Physiol Heart Circ Physiol (2006) 2.19

Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol (2006) 2.19

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med (2000) 2.11

Invited review: aging and the cardiovascular system. J Appl Physiol (1985) (2003) 2.08

The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta (1995) 2.06

Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol (2001) 2.03

Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ (1995) 1.97

Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc Res (2006) 1.92

Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91

Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation (2001) 1.90

Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation (2001) 1.89

Plant foods and herbal sources of resveratrol. J Agric Food Chem (2002) 1.87

Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr (2005) 1.85

Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure. Am J Hypertens (2009) 1.82

Berry phenolics and their antioxidant activity. J Agric Food Chem (2001) 1.76

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 1.73

Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition (2005) 1.72

Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther (2013) 1.69

Resveratrol and health--a comprehensive review of human clinical trials. Mol Nutr Food Res (2011) 1.68

Risks and safety of polyphenol consumption. Am J Clin Nutr (2005) 1.67

Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients (2010) 1.66

Resveratrol attenuates ventricular arrhythmias and improves the long-term survival in rats with myocardial infarction. Cardiovasc Drugs Ther (2008) 1.63

Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr (2007) 1.61

Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med (2004) 1.61

Molecular targets of oxidative stress. Biochem J (2011) 1.60

A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem (2003) 1.59

EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab (2007) 1.58

Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr (2005) 1.58

Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. J Agric Food Chem (2004) 1.57

Platelet PECAM-1 inhibits thrombus formation in vivo. Blood (2005) 1.53

Reactive oxygen species: from health to disease. Swiss Med Wkly (2012) 1.52

Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr (2009) 1.52

Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis. Eur J Nutr (2012) 1.51

Quercetin reduces blood pressure in hypertensive subjects. J Nutr (2007) 1.51

The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J (2007) 1.50

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem Toxicol (2006) 1.48

Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr (2010) 1.47

Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. J Agric Food Chem (2008) 1.47

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther (2011) 1.46

Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol (1992) 1.44

Flavanols and anthocyanins in cardiovascular health: a review of current evidence. Int J Mol Sci (2010) 1.43

Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun (1998) 1.40

Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia. Am J Physiol Heart Circ Physiol (2001) 1.39

Anthocyanins in cardiovascular disease. Adv Nutr (2011) 1.39

Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol (2003) 1.39

The protective effect of habitual tea consumption on hypertension. Arch Intern Med (2004) 1.37

Iron absorption and phenolic compounds: importance of different phenolic structures. Eur J Clin Nutr (1989) 1.37

The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS Med (2011) 1.36

Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol (1998) 1.34

Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol (1996) 1.33

Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis (1999) 1.32

Coffee and tea consumption in the Scottish Heart Health Study follow up: conflicting relations with coronary risk factors, coronary disease, and all cause mortality. J Epidemiol Community Health (1999) 1.31

Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J (2004) 1.31

Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr (2007) 1.30

Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci (2005) 1.29

Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem (2007) 1.28

Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr (2008) 1.28

The future of flavonoid research. Br J Nutr (2010) 1.28

Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep (2009) 1.28

Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr (2010) 1.26

Antioxidant Activity of Berry and Fruit Wines and Liquors. J Agric Food Chem (1998) 1.26

Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism (2008) 1.25

Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res (2004) 1.25

Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Microcirc (2012) 1.24

Articles by these authors

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem (2003) 2.98

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol (2006) 2.04

The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta (2008) 1.38

A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat (2007) 1.21

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J Biol Chem (2002) 1.14

Protective effects of methyl gallate on H2O2-induced apoptosis in PC12 cells. Biochem Biophys Res Commun (2010) 1.06

Epinephrine: a short- and long-term regulator of stress and development of illness : a potential new role for epinephrine in stress. Cell Mol Neurobiol (2011) 0.95

Regulation of the rat phenylethanolamine N-methyltransferase gene by transcription factors Sp1 and MAZ. Mol Pharmacol (2003) 0.90

Oxidative stress in aging--matters of the heart and mind. Int J Mol Sci (2013) 0.89

Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res (2007) 0.88

Protective effects of polyphenolic compounds on oxidative stress-induced cytotoxicity in PC12 cells. Can J Physiol Pharmacol (2010) 0.87

Oxidative stress and cardiovascular health: therapeutic potential of polyphenols. Can J Physiol Pharmacol (2013) 0.85

Genetic mechanisms for adrenergic control during stress. Ann N Y Acad Sci (2004) 0.82

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons. J Org Chem (2002) 0.82

Stress and adrenergic function: HIF1α, a potential regulatory switch. Cell Mol Neurobiol (2010) 0.82

Regulation of the phenylethanolamine N-methyltransferase gene in the adrenal gland of the spontaneous hypertensive rat. Neurosci Lett (2009) 0.80

Septic sera induces apoptosis and DNA fragmentation factor 40 activation in fibroblasts. Biochem Biophys Res Commun (2011) 0.79

Genes involved in pancreatic islet cell rejuvenation. Indian J Med Res (2013) 0.78

Adrenergic responses to stress: transcriptional and post-transcriptional changes. Ann N Y Acad Sci (2008) 0.77

Serovar prevalence of Leptospira in semirural India and the development of an IgM-based indirect ELISA. J Infect Dev Ctries (2017) 0.77

Influenza A induced cellular signal transduction pathways. J Thorac Dis (2013) 0.76

Role of reactive oxygen species in the neural and hormonal regulation of the PNMT gene in PC12 cells. Oxid Med Cell Longev (2011) 0.75

Management of Croup in the Emergency Department: The Role of Multidose Nebulized Epinephrine. Pediatr Emerg Care (2017) 0.75

Adjuvant poly(N-isopropylacrylamide) generates more efficient monoclonal antibodies against truncated recombinant histidine-rich protein2 of Plasmodium falciparum for malaria diagnosis. Biotechnol J (2015) 0.75