The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 3875339)

Published in Free Radic Biol Med on October 01, 2013

Authors

R Steven Esworthy1, Byung-Wook Kim, Yufeng Wang, Qiang Gao, James H Doroshow, Thomas L Leto, Fong-Fong Chu

Author Affiliations

1: Department of Radiation Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

Articles cited by this

The inflammasomes. Cell (2010) 19.37

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

The gastrointestinal epithelium and its autochthonous bacterial flora. J Exp Med (1968) 10.84

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol (2007) 7.58

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem (2000) 6.54

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55

Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol (2007) 4.75

Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe (2009) 4.21

Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Science (2000) 4.12

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J (2003) 3.44

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96

Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut (2008) 2.90

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50

Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res (2004) 2.42

Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect Immun (2011) 2.24

Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem (2007) 2.06

Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol (2001) 2.04

Cell death and infection: a double-edged sword for host and pathogen survival. J Cell Biol (2011) 1.69

CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med (2010) 1.64

The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization. PLoS One (2011) 1.57

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. J Cell Sci (2009) 1.56

Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol (2011) 1.54

Selenium deficiency and viral infection. J Nutr (2003) 1.45

Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol (2005) 1.45

Regulation of cell structure and function by actin-binding proteins: villin's perspective. FEBS Lett (2008) 1.40

Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ Res (2011) 1.36

Structural, expression, and evolutionary analysis of mouse CIAS1. Gene (2004) 1.33

Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One (2009) 1.16

Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. J Nutr (2005) 1.15

Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochem Biophys Res Commun (2010) 1.15

Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. Carcinogenesis (2010) 1.14

Salmonella typhimurium infection increases p53 acetylation in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2010) 1.05

Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol (2010) 1.04

Salmonella enterica: a surprisingly well-adapted intracellular lifestyle. Front Microbiol (2012) 1.02

A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. MBio (2011) 1.02

Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J (1998) 1.01

Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol (2000) 1.01

A Strong Impact of Genetic Background on Gut Microflora in Mice. Int J Inflam (2010) 0.99

Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem (2011) 0.97

Salmonella induces prominent gene expression in the rat colon. BMC Microbiol (2007) 0.96

Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice. Free Radic Biol Med (2010) 0.95

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. PLoS One (2011) 0.94

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status. Free Radic Biol Med (2013) 0.92

Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. Infect Immun (2011) 0.91

Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis development. Inflamm Bowel Dis (2011) 0.90

Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS One (2012) 0.89

Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J (2010) 0.87

Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2. Inflamm Bowel Dis (2010) 0.86

Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection. BMC Immunol (2009) 0.86

The syndrome of inherited partial SBP2 deficiency in humans. Antioxid Redox Signal (2010) 0.84

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death. J Biol Chem (2011) 0.84

The expression of an intestinal form of glutathione peroxidase (GSHPx-GI) in rat intestinal epithelium. Arch Biochem Biophys (1995) 0.83

Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat. Toxicol Pathol (2005) 0.82

Regulation of villin by wnt5a/ror2 signaling in human intestinal cells. Front Physiol (2011) 0.81

Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice. Biol Trace Elem Res (2011) 0.78

The pathogenicity of an enteric Citrobacter rodentium Infection is enhanced by deficiencies in the antioxidants selenium and vitamin E. Infect Immun (2011) 0.78

Articles by these authors

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44

Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase I randomised controlled trial. Lancet (2006) 4.22

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies. J Clin Oncol (2009) 4.14

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res (2012) 3.74

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J (2003) 3.44

Age distribution of human gene families shows significant roles of both large- and small-scale duplications in vertebrate evolution. Nat Genet (2002) 3.39

Criteria for the use of omics-based predictors in clinical trials. Nature (2013) 3.15

Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neurosci Lett (2006) 2.93

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov (2012) 2.74

Compressing drug development timelines in oncology using phase '0' trials. Nat Rev Cancer (2007) 2.52

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50

Physics. Learning and scientific reasoning. Science (2009) 2.49

The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem (2004) 2.48

Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res (2004) 2.42

Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines. Mol Cancer Ther (2010) 2.38

The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. Cancer Res (2013) 2.27

Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite. Genome Res (2003) 2.18

Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp (2009) 2.15

Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res (2010) 2.12

Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res (2008) 2.08

Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas. Cancer Res (2011) 2.08

AACR-FDA-NCI Cancer Biomarkers Collaborative consensus report: advancing the use of biomarkers in cancer drug development. Clin Cancer Res (2010) 2.06

Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China. N Engl J Med (2014) 2.01

Cediranib for metastatic alveolar soft part sarcoma. J Clin Oncol (2013) 1.99

Phase III clinical trial development: a process of chutes and ladders. Clin Cancer Res (2010) 1.97

Proteomics approach reveals novel proteins on the surface of malaria-infected erythrocytes. Mol Biochem Parasitol (2004) 1.96

Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport (2006) 1.92

CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer (2005) 1.89

Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group. J Clin Oncol (2008) 1.87

Designing phase 0 cancer clinical trials. Clin Cancer Res (2008) 1.85

Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration. BMC Med (2013) 1.84

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol Cell Biol (2006) 1.80

Endoscopic clip closure versus surgery for the treatment of iatrogenic colon perforations developed during diagnostic colonoscopy: a review of 115,285 patients. Surg Endosc (2012) 1.80

Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med (2006) 1.76

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells. Nucleic Acids Res (2011) 1.76

Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts. Clin Cancer Res (2008) 1.70

Phase 0 clinical trials: recommendations from the Task Force on Methodology for the Development of Innovative Cancer Therapies. Eur J Cancer (2008) 1.70

Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem (2003) 1.70

Prognostic indicators and survival in patients with stage IIIB inflammatory breast carcinoma after dose-intense chemotherapy. J Clin Oncol (2004) 1.66

Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells. Clin Cancer Res (2010) 1.65

Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice. Mol Interv (2007) 1.64

Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax. Proc Natl Acad Sci U S A (2003) 1.62

Immunohistochemical detection of poly(ADP-ribose) polymerase inhibition by ABT-888 in patients with refractory solid tumors and lymphomas. Cancer Biol Ther (2009) 1.60

A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study. Clin Cancer Res (2008) 1.60

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent. Cell Cycle (2011) 1.60

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements. Nat Rev Drug Discov (2010) 1.59

Evaluation of the Xpert MTB/RIF assay in gastric lavage aspirates for diagnosis of smear-negative childhood pulmonary tuberculosis. Pediatr Infect Dis J (2014) 1.58

Picornavirus uncoating intermediate captured in atomic detail. Nat Commun (2013) 1.57

A prospective randomized controlled trial of semi-mechanical versus hand-sewn or circular stapled esophagogastrostomy for prevention of anastomotic stricture. World J Surg (2013) 1.56

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther (2013) 1.55

Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder. Brain Res (2009) 1.54

A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res (2012) 1.53

Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.51

Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection. J Hepatol (2010) 1.50

Advances in using PARP inhibitors to treat cancer. BMC Med (2012) 1.49

Genome-wide depletion of replication initiation events in highly transcribed regions. Genome Res (2011) 1.44

Phase perfection in zinc Blende and Wurtzite III-V nanowires using basic growth parameters. Nano Lett (2010) 1.41

Drug development in oncology: classical cytotoxics and molecularly targeted agents. Br J Clin Pharmacol (2006) 1.40

An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma. Clin Res Hepatol Gastroenterol (2013) 1.39

Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: a randomized, placebo-controlled, double-blind, Phase I clinical trial. Vaccine (2012) 1.38

NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes. J Immunol (2003) 1.38

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother Pharmacol (2007) 1.37

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity. Mol Cancer Ther (2009) 1.37

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur J Cancer (2009) 1.36

Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J (2008) 1.36

Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. Proc Natl Acad Sci U S A (2012) 1.35

Structural, proton-transfer, thermodynamic and nonlinear optical studies of (E)-2-((2-hydroxyphenyl)iminiomethyl)phenolate. Spectrochim Acta A Mol Biomol Spectrosc (2012) 1.35

The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells. J Immunol (2008) 1.35

Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity. Clin Cancer Res (2010) 1.35

An interwoven Fe3L3 trigonal metallamacrocycle from an in situ ligand hydrolysis reaction. Dalton Trans (2008) 1.34

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med (2012) 1.31

Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation. J Natl Cancer Inst (2010) 1.30

Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies. Clin Cancer Res (2007) 1.27

Establishing China's national standards of antigen content and neutralizing antibody responses for evaluation of enterovirus 71 (EV71) vaccines. Vaccine (2011) 1.27

Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J Virol (2009) 1.27

Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells. PLoS One (2011) 1.26

Diagnostic yield of tissue sampling using a bite-on-bite technique for incidental subepithelial lesions. Korean J Intern Med (2009) 1.25

Gastric Metastasis from Ovarian Adenocarcinoma Presenting as a Submucosal Tumor without Ulceration. Gut Liver (2009) 1.25

Assessment of serum matrix metalloproteinases MMP-2 and MMP-9 after human liver transplantation: increased serum MMP-9 level in acute rejection. Transplantation (2004) 1.25

Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors. Clin Cancer Res (2011) 1.22

Wee1 kinase as a target for cancer therapy. Cell Cycle (2013) 1.22

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. J Pharmacol Exp Ther (2014) 1.19

IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. Mol Cancer (2011) 1.19

Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2012) 1.18

Efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasia: a meta-analysis. Dig Dis Sci (2014) 1.18

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol (2012) 1.18

Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection. Vaccine (2011) 1.18

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues. Free Radic Res (2009) 1.16

Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer. Free Radic Biol Med (2004) 1.16

Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study. Clin Cancer Res (2007) 1.15

Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. J Nutr (2005) 1.15

Ultralow surface recombination velocity in InP nanowires probed by terahertz spectroscopy. Nano Lett (2012) 1.15

Enhanced resting-state brain activities in ADHD patients: a fMRI study. Brain Dev (2007) 1.14

Overexpression of an H+-PPase gene from Thellungiella halophila in cotton enhances salt tolerance and improves growth and photosynthetic performance. Plant Cell Physiol (2008) 1.14

Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytes. PLoS One (2010) 1.14

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol Biol Cell (2006) 1.14

Electronic properties of GaAs, InAs and InP nanowires studied by terahertz spectroscopy. Nanotechnology (2013) 1.13

Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res (2008) 1.13

Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding. World J Gastroenterol (2008) 1.13