Published in Arch Biochem Biophys on October 03, 2013
QM/MM molecular dynamics study of the galactopyranose → galactofuranose reaction catalysed by Trypanosoma cruzi UDP-galactopyranose mutase. PLoS One (2014) 0.79
Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics. Biochemistry (2014) 0.76
In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction. Biochemistry (2016) 0.75
Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase. Arch Biochem Biophys (2017) 0.75
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52
Molecular dynamics: survey of methods for simulating the activity of proteins. Chem Rev (2006) 3.18
Rational protein crystallization by mutational surface engineering. Structure (2004) 2.87
Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci (2007) 2.57
A unique catalytic mechanism for UDP-galactopyranose mutase. Nat Struct Mol Biol (2004) 2.15
Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase. J Bacteriol (1996) 1.95
Cell wall core galactofuran synthesis is essential for growth of mycobacteria. J Bacteriol (2001) 1.90
UDP-galactopyranose mutase has a novel structure and mechanism. Nat Struct Biol (2001) 1.70
Universal screening methods and applications of ThermoFluor. J Biomol Screen (2006) 1.69
Polysaccharides synthesised by micro-organisms: The molecular structure of galactocarolose produced from glucose by Penicillium Charlesii G. Smith. Biochem J (1937) 1.56
The mobile flavin of 4-OH benzoate hydroxylase. Science (1994) 1.55
Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus. Eukaryot Cell (2008) 1.47
UDP-galactofuranose precursor required for formation of the lipopolysaccharide O antigen of Klebsiella pneumoniae serotype O1 is synthesized by the product of the rfbDKPO1 gene. J Biol Chem (1997) 1.45
Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact. Glycobiology (2011) 1.45
Flavoenzymes that catalyse reactions with no net redox change. Nat Prod Rep (2002) 1.44
Bacterial nitric-oxide synthases operate without a dedicated redox partner. J Biol Chem (2008) 1.41
Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase. Arch Biochem Biophys (2005) 1.41
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues. Tuber Lung Dis (1997) 1.38
Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens. Eukaryot Cell (2005) 1.36
ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding. FEBS J (2009) 1.32
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol (2005) 1.30
Chemistry and biology of galactofuranose-containing polysaccharides. Chembiochem (2009) 1.28
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Future Med Chem (2010) 1.27
Flavoenzymes: versatile catalysts in biosynthetic pathways. Nat Prod Rep (2013) 1.23
Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J Biol Chem (2007) 1.22
X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin. Biochemistry (2009) 1.18
A structurally conserved water molecule in Rossmann dinucleotide-binding domains. Protein Sci (2002) 1.17
Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus. Arch Biochem Biophys (2010) 1.13
Mechanistic investigation of UDP-galactopyranose mutase from Escherichia coli using 2- and 3-fluorinated UDP-galactofuranose as probes. J Am Chem Soc (2001) 1.11
Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Bioorg Chem (2003) 1.10
Ligand binding and substrate discrimination by UDP-galactopyranose mutase. J Mol Biol (2009) 1.10
The biosynthesis of galactofuranosyl residues in galactocarolose. Biochem J (1971) 1.07
Glycobiology of Trypanosoma cruzi. Adv Carbohydr Chem Biochem (2009) 1.07
Structural basis of substrate binding to UDP-galactopyranose mutase: crystal structures in the reduced and oxidized state complexed with UDP-galactopyranose and UDP. J Mol Biol (2009) 1.07
Biogenesis of galactocarolose by Penicillium charlesii. I. Incorporation of C14 from glucose-C14 and DL-tartrate-1,4-C14 into polyglactose. Arch Biochem Biophys (1960) 1.02
Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate. Biochemistry (2003) 1.02
Initiating a crystallographic study of UDP-galactopyranose mutase from Escherichia coli. Acta Crystallogr D Biol Crystallogr (1999) 1.01
Biosynthesis of T1 antigen in Salmonella: origin of D-galactofuranose and D-ribofuranose residues. J Bacteriol (1971) 1.00
Crystal structures and small-angle x-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus. J Biol Chem (2012) 0.97
Biosynthesis of T1 antigen in Salmonella: biosynthesis in a cell-free system. J Bacteriol (1971) 0.96
Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. J Biol Chem (2011) 0.96
Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations. J Am Chem Soc (2008) 0.96
Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease. PLoS One (2012) 0.95
Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease. Enzyme Res (2011) 0.94
Characterization of the Caenorhabditis elegans UDP-galactopyranose mutase homolog glf-1 reveals an essential role for galactofuranose metabolism in nematode surface coat synthesis. Dev Biol (2009) 0.94
Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism. Org Lett (2007) 0.93
Drug discovery for a new generation of covalent drugs. Expert Opin Drug Discov (2012) 0.93
Structural insight into the unique substrate binding mechanism and flavin redox state of UDP-galactopyranose mutase from Aspergillus fumigatus. J Biol Chem (2012) 0.92
Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation. Biochemistry (2012) 0.92
Flavin redox switching of protein functions. Antioxid Redox Signal (2010) 0.90
Chemoenzymatic synthesis, inhibition studies, and X-ray crystallographic analysis of the phosphono analog of UDP-Galp as an inhibitor and mechanistic probe for UDP-galactopyranose mutase. J Mol Biol (2010) 0.89
Substrate directs enzyme dynamics by bridging distal sites: UDP-galactopyranose mutase. Proteins (2009) 0.87
1,4-Anhydrogalactopyranose is not an intermediate of the mutase catalyzed UDP-galactopyranose/furanose interconversion. Bioorg Med Chem Lett (2006) 0.86
Enzymatic synthesis of UDP-(3-deoxy-3-fluoro)-D-galactose and UDP-(2-deoxy-2-fluoro)-D-galactose and substrate activity with UDP-galactopyranose mutase. Carbohydr Res (2000) 0.86
Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase. J Am Chem Soc (2012) 0.86
Substrate-dependent dynamics of UDP-galactopyranose mutase: Implications for drug design. Protein Sci (2013) 0.84
Noncanonical reactions of flavoenzymes. Int J Mol Sci (2012) 0.83
Tautomerization in the UDP-galactopyranose mutase mechanism: a DFT-cluster and QM/MM investigation. J Phys Chem B (2012) 0.82
Towards the crystal structure elucidation of eukaryotic UDP-galactopyranose mutase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.82
Expression, purification and preliminary X-ray crystallographic analysis of UDP-galactopyranose mutase from Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.76