Published in Enzyme Res on May 25, 2011
The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. FASEB J (2012) 1.40
Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family. PLoS One (2013) 0.95
Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease. PLoS One (2012) 0.95
Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation. Biochemistry (2012) 0.92
Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans. J Biol Chem (2013) 0.89
Targeting UDP-galactopyranose mutases from eukaryotic human pathogens. Curr Pharm Des (2013) 0.85
Noncanonical reactions of flavoenzymes. Int J Mol Sci (2012) 0.83
Structure, mechanism, and dynamics of UDP-galactopyranose mutase. Arch Biochem Biophys (2013) 0.82
Stage-specific differential gene expression in Leishmania infantum: from the foregut of Phlebotomus perniciosus to the human phagocyte. BMC Genomics (2014) 0.81
QM/MM molecular dynamics study of the galactopyranose → galactofuranose reaction catalysed by Trypanosoma cruzi UDP-galactopyranose mutase. PLoS One (2014) 0.79
Alkyl galactofuranosides strongly interact with Leishmania donovani membrane and provide antileishmanial activity. Antimicrob Agents Chemother (2014) 0.77
Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics. Biochemistry (2014) 0.76
The efficacy of L. (L.) chagasi excreted-secreted antigens (ESAs) for visceral leishmaniasis diagnosis is due to low levels of cross-reactivity. Am J Trop Med Hyg (2013) 0.76
In silico work flow for scaffold hopping in Leishmania. BMC Res Notes (2014) 0.75
Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase. Arch Biochem Biophys (2017) 0.75
ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem J (1993) 4.96
Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster. J Bacteriol (1994) 3.61
Short-chain dehydrogenases/reductases (SDR): the 2002 update. Chem Biol Interact (2003) 3.46
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci (1999) 3.40
Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect Immun (1994) 2.60
Structure and function of enzymes of the Leloir pathway for galactose metabolism. J Biol Chem (2003) 2.49
The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J (1996) 2.47
Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Trop (2009) 2.37
Galactofuranose-containing glycoconjugates in trypanosomatids. Glycobiology (1995) 2.32
Use of the green fluorescent protein as a marker in transfected Leishmania. Mol Biochem Parasitol (1996) 2.19
Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A (2000) 2.11
Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase. J Bacteriol (1996) 1.95
Cell wall core galactofuran synthesis is essential for growth of mycobacteria. J Bacteriol (2001) 1.90
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts. Proc Natl Acad Sci U S A (2003) 1.89
Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67. Carbohydr Res (1998) 1.72
Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids. J Biol Chem (1990) 1.64
Genetic characterization of glucose transporter function in Leishmania mexicana. Proc Natl Acad Sci U S A (2003) 1.64
Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1. J Bacteriol (1991) 1.55
Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. Proc Natl Acad Sci U S A (2002) 1.49
Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus. Eukaryot Cell (2008) 1.47
Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol (2001) 1.45
Galactofuranose metabolism: a potential target for antimicrobial chemotherapy. Cell Mol Life Sci (2003) 1.45
UDP-galactofuranose precursor required for formation of the lipopolysaccharide O antigen of Klebsiella pneumoniae serotype O1 is synthesized by the product of the rfbDKPO1 gene. J Biol Chem (1997) 1.45
Conserved domains of glycosyltransferases. Glycobiology (1999) 1.45
Expression of an unusual acidic glycoconjugate in Leishmania donovani. J Biol Chem (1984) 1.44
Leishmaniasis: current treatment and prospects for new drugs and vaccines. Curr Med Chem (2009) 1.43
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues. Tuber Lung Dis (1997) 1.38
Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Eukaryot Cell (2007) 1.37
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase. J Biol Chem (2001) 1.36
Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania. Proc Natl Acad Sci U S A (1993) 1.36
Chagas disease: 100 years after its discovery. A systemic review. Acta Trop (2010) 1.36
Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens. Eukaryot Cell (2005) 1.36
Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies. J Cell Sci (2000) 1.33
Basic cell biology of Trypanosoma cruzi. Curr Pharm Des (2002) 1.32
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol (2005) 1.30
The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. J Biol Chem (2005) 1.30
Galactofuranose containing molecules in Aspergillus fumigatus. Med Mycol (2008) 1.29
Chemistry and biology of galactofuranose-containing polysaccharides. Chembiochem (2009) 1.28
The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles. Mol Biochem Parasitol (2001) 1.24
Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J Biol Chem (2007) 1.22
Identification of inhibitors for UDP-galactopyranose mutase. J Am Chem Soc (2004) 1.19
Structural investigations on T1 lipopolysaccharides. Eur J Biochem (1969) 1.19
X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin. Biochemistry (2009) 1.18
Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi Epimastigotes. J Biol Chem (1991) 1.17
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library. Antimicrob Agents Chemother (2003) 1.14
Evidence for accessory pathway of galactose metabolism in mammalian liver. Science (1957) 1.13
Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem (2010) 1.13
Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus. Arch Biochem Biophys (2010) 1.13
High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides. Mol Biochem Parasitol (2003) 1.13
Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth. J Am Chem Soc (2008) 1.12
Specificity and kinetics of hexose transport in Trypanosoma brucei. Biochim Biophys Acta (1989) 1.11
Structural characterization of the major glycosylphosphatidylinositol membrane-anchored glycoprotein from epimastigote forms of Trypanosoma cruzi Y-strain. J Biol Chem (1995) 1.11
Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases. Biol Chem (2005) 1.11
Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications. Bioorg Chem (2003) 1.10
Chemical structure and antigenic aspects of complexes obtained from epimastigotes of Trypanosoma cruzi. Biochemistry (1983) 1.09
Deficiency in beta1,3-galactosyltransferase of a Leishmania major lipophosphoglycan mutant adversely influences the Leishmania-sand fly interaction. J Biol Chem (1996) 1.07
Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant. Eukaryot Cell (2006) 1.07
Glycobiology of Trypanosoma cruzi. Adv Carbohydr Chem Biochem (2009) 1.07
Structural basis of substrate binding to UDP-galactopyranose mutase: crystal structures in the reduced and oxidized state complexed with UDP-galactopyranose and UDP. J Mol Biol (2009) 1.07
Molecular epidemiology for vector research on leishmaniasis. Int J Environ Res Public Health (2010) 1.06
New antileishmanial candidates and lead compounds. Curr Opin Chem Biol (2010) 1.06
The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. Mol Biochem Parasitol (2006) 1.05
Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett (2006) 1.03
Aspergillus nidulans UDP-galactopyranose mutase, encoded by ugmA plays key roles in colony growth, hyphal morphogenesis, and conidiation. Fungal Genet Biol (2008) 1.02
Cell-free biosynthesis of lipophosphoglycan from Leishmania donovani. Characterization of microsomal galactosyltransferase and mannosyltransferase activities. J Biol Chem (1991) 1.02
O-glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi. Biochem J (1994) 1.02
Hexadecylpalmitoylglycerol or ceramide is linked to similar glycophosphoinositol anchor-like structures in Trypanosoma cruzi. Eur J Biochem (1993) 1.01
Biosynthesis of T1 antigen in Salmonella: origin of D-galactofuranose and D-ribofuranose residues. J Bacteriol (1971) 1.00
A monoclonal antibody directed to terminal residue of beta-galactofuranose of a glycolipid antigen isolated from Paracoccidioides brasiliensis: cross-reactivity with Leishmania major and Trypanosoma cruzi. Glycobiology (1997) 0.99
The LPG1 gene family of Leishmania major. Mol Biochem Parasitol (2004) 0.98
A single UDP-galactofuranose transporter is required for galactofuranosylation in Aspergillus fumigatus. J Biol Chem (2009) 0.98
Carbohydrate structures of three novel phosphoinositol-containing sphingolipids from the yeast Histoplasma capsulatum. Biochemistry (1984) 0.98
Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage? J Biol Chem (2009) 0.97
Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major. J Mol Biol (2010) 0.94
N-linked high mannose-type oligosaccharides in the protozoa Crithidia fasciculata and Crithidia harmosa contain galactofuranose residues. J Biol Chem (1986) 0.94
Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology. Adv Parasitol (2004) 0.94
Galactofuranose-containing glycoconjugates of epimastigote and trypomastigote forms of Trypanosoma cruzi. Mol Biochem Parasitol (1993) 0.93
Trypanosomatid and fungal glycolipids and sphingolipids as infectivity factors and potential targets for development of new therapeutic strategies. Biochim Biophys Acta (2007) 0.93
Structural variation in the glycoinositolphospholipids of different strains of Trypanosoma cruzi. Glycoconj J (1996) 0.92
Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes. J Biol Chem (2005) 0.90
Trypanosoma cruzi: involvement of glycoinositolphospholipids in the attachment to the luminal midgut surface of Rhodnius prolixus. Exp Parasitol (2007) 0.87
Structural characterization of several galactofuranose-containing, high-mannose-type oligosaccharides present in glycoproteins of the trypanosomatid Leptomonas samueli. Biochemistry (1988) 0.86
Reactivity of MEST-1 (antigalactofuranose) with Trypanosoma cruzi glycosylinositol phosphorylceramides (GIPCs): immunolocalization of GIPCs in acidic vesicles of epimastigotes. Clin Diagn Lab Immunol (2001) 0.85
Heterogeneity in the biosynthesis of mucin O-glycans from Trypanosoma cruzi tulahuen strain with the expression of novel galactofuranosyl-containing oligosaccharides. Biochemistry (2004) 0.85
Role of beta-D-galactofuranose in Leishmania major macrophage invasion. Infect Immun (2002) 0.85
Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite. Org Lett (2009) 0.84
Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major. Glycobiology (2010) 0.84
Characterization of protein-linked oligosaccharides in trypanosomatid flagellates. Mol Biochem Parasitol (1986) 0.83
Structure of O-glycosidically linked oligosaccharides from glycoproteins of Trypanosoma cruzi CL-Brener strain: evidence for the presence of O-linked sialyl-oligosaccharides. Glycobiology (2001) 0.82
A novel sialylated and galactofuranose-containing O-linked glycan, Neu5Acalpha2-->3Galpbeta1-->6(Galfbeta1-->4)GlcNAc, is expressed on the sialoglycoprotein of Trypanosoma cruzi Dm28c. Mol Biochem Parasitol (2003) 0.79
Terminal beta-D-galactofuranosyl epitopes recognized by antibodies that inhibit Trypanosoma cruzi internalization into mammalian cells. Eur J Biochem (1989) 0.79
Free and protein-linked glycoinositolphospholipids in Trypanosoma cruzi. Braz J Med Biol Res (1994) 0.76
Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus. Arch Biochem Biophys (2010) 1.13
Aspergillus fumigatus SidA is a highly specific ornithine hydroxylase with bound flavin cofactor. Biochemistry (2010) 1.04
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications. Autophagy (2015) 1.00
Crystal structures and small-angle x-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus. J Biol Chem (2012) 0.97
Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease. PLoS One (2012) 0.95
Crystal structures of Trypanosoma cruzi UDP-galactopyranose mutase implicate flexibility of the histidine loop in enzyme activation. Biochemistry (2012) 0.92
Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases. Biochemistry (2012) 0.88
Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase. J Am Chem Soc (2012) 0.86
Targeting UDP-galactopyranose mutases from eukaryotic human pathogens. Curr Pharm Des (2013) 0.85
Isolation and characterization of functional Leishmania major virulence factor UDP-galactopyranose mutase. Biochem Biophys Res Commun (2011) 0.84
Substrate-dependent dynamics of UDP-galactopyranose mutase: Implications for drug design. Protein Sci (2013) 0.84
Substrate binding modulates the activity of Mycobacterium smegmatis G, a flavin-dependent monooxygenase involved in the biosynthesis of hydroxamate-containing siderophores. Biochemistry (2011) 0.84
Dual role of NADP(H) in the reaction of a flavin dependent N-hydroxylating monooxygenase. Biochim Biophys Acta (2012) 0.83
Recombinant expression, purification, and characterization of ThmD, the oxidoreductase component of tetrahydrofuran monooxygenase. Arch Biochem Biophys (2010) 0.82
Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Biochemistry (2007) 0.82
Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase. Enzyme Res (2011) 0.81
Monitoring the reductive and oxidative half-reactions of a flavin-dependent monooxygenase using stopped-flow spectrophotometry. J Vis Exp (2012) 0.78
UDP-galactopyranose mutases from Leishmania species that cause visceral and cutaneous leishmaniasis. Arch Biochem Biophys (2013) 0.77
Role of Ser-257 in the sliding mechanism of NADP(H) in the reaction catalyzed by the Aspergillus fumigatus flavin-dependent ornithine N5-monooxygenase SidA. J Biol Chem (2013) 0.77
Tryptophan-47 in the active site of Methylophaga sp. strain SK1 flavin-monooxygenase is important for hydride transfer. Arch Biochem Biophys (2013) 0.77
C4a-hydroperoxyflavin formation in N-hydroxylating flavin monooxygenases is mediated by the 2'-OH of the nicotinamide ribose of NADP⁺. Biochemistry (2013) 0.76
Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics. Biochemistry (2014) 0.76
A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases. Anal Biochem (2012) 0.76
Mechanism of N-hydroxylation catalyzed by flavin-dependent monooxygenases. J Org Chem (2015) 0.75
Developmental expression of Xenopus myosin 1d and identification of a myo1d tail homology that overlaps TH1. Dev Growth Differ (2009) 0.75