Toward rational protein crystallization: A Web server for the design of crystallizable protein variants.

PubWeight™: 2.57‹?› | Rank: Top 1%

🔗 View Article (PMC 2203352)

Published in Protein Sci on August 01, 2007

Authors

Lukasz Goldschmidt1, David R Cooper, Zygmunt S Derewenda, David Eisenberg

Author Affiliations

1: Howard Hughes Medical Institute, University of California, Los Angeles-DOE Institute of Genomics and Proteomics, Los Angeles, California 90095-1570, USA.

Articles citing this

X-ray structures of the hexameric building block of the HIV capsid. Cell (2009) 4.08

Alternating access in maltose transporter mediated by rigid-body rotations. Mol Cell (2009) 2.20

FFAS server: novel features and applications. Nucleic Acids Res (2011) 1.52

MamA as a Model Protein for Structure-Based Insight into the Evolutionary Origins of Magnetotactic Bacteria. PLoS One (2015) 1.51

Improving the chances of successful protein structure determination with a random forest classifier. Acta Crystallogr D Biol Crystallogr (2014) 1.50

High-throughput crystallography for structural genomics. Curr Opin Struct Biol (2009) 1.44

Application of protein engineering to enhance crystallizability and improve crystal properties. Acta Crystallogr D Biol Crystallogr (2010) 1.38

Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell (2010) 1.33

Computational design of a protein crystal. Proc Natl Acad Sci U S A (2012) 1.23

Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (2012) 1.18

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure (2012) 1.09

The role of entropy and polarity in intermolecular contacts in protein crystals. Acta Crystallogr D Biol Crystallogr (2009) 1.06

The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell (2013) 1.05

Predicting protein crystallization propensity from protein sequence. J Struct Funct Genomics (2010) 1.04

Crystal structure of KLHL3 in complex with Cullin3. PLoS One (2013) 1.02

The Protein Structure Initiative Structural Biology Knowledgebase Technology Portal: a structural biology web resource. J Struct Funct Genomics (2012) 1.00

Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. J Biol Chem (2011) 0.99

CRYSTALP2: sequence-based protein crystallization propensity prediction. BMC Struct Biol (2009) 0.99

An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Sci (2011) 0.98

It's all in the crystals…. Acta Crystallogr D Biol Crystallogr (2011) 0.98

Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. ACS Chem Biol (2015) 0.97

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex. Elife (2014) 0.97

Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry (2009) 0.97

Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proc Natl Acad Sci U S A (2013) 0.96

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep (2013) 0.95

Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization. Nat Struct Mol Biol (2015) 0.95

Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol (2012) 0.92

Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase. Plant Physiol (2011) 0.91

SCMCRYS: predicting protein crystallization using an ensemble scoring card method with estimating propensity scores of P-collocated amino acid pairs. PLoS One (2013) 0.90

Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil. J Biol Chem (2012) 0.89

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc Natl Acad Sci U S A (2014) 0.89

Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde. Acta Crystallogr D Biol Crystallogr (2009) 0.88

New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization. Protein Sci (2010) 0.88

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. PLoS One (2012) 0.87

Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus. J Mol Biol (2010) 0.87

RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74. Nucleic Acids Res (2013) 0.87

Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. Acta Crystallogr D Biol Crystallogr (2009) 0.86

Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. J Mol Biol (2009) 0.85

Conversion of scFv peptide-binding specificity for crystal chaperone development. Protein Eng Des Sel (2011) 0.85

Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae. J Biol Chem (2014) 0.85

The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46. J Biol Chem (2010) 0.84

Enhanced crystal packing due to solvent reorganization through reductive methylation of lysine residues in oxidoreductase from Streptococcus pneumoniae. J Struct Funct Genomics (2010) 0.84

Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein. Biochemistry (2013) 0.84

Improvement of crystal quality by surface mutations of beta-lactamase Toho-1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.83

Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proc Natl Acad Sci U S A (2014) 0.83

Substrate and metal ion promiscuity in mannosylglycerate synthase. J Biol Chem (2011) 0.83

Characterizing protein crystal contacts and their role in crystallization: rubredoxin as a case study. Soft Matter (2014) 0.82

Structure-based design of bacterial nitric oxide synthase inhibitors. J Med Chem (2015) 0.82

Structure, mechanism, and dynamics of UDP-galactopyranose mutase. Arch Biochem Biophys (2013) 0.82

Structures of two bacterial resistance factors mediating tRNA-dependent aminoacylation of phosphatidylglycerol with lysine or alanine. Proc Natl Acad Sci U S A (2015) 0.81

Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology. PLoS One (2013) 0.81

Protein stability: a crystallographer's perspective. Acta Crystallogr F Struct Biol Commun (2016) 0.81

Structural features and chaperone activity of the NudC protein family. J Mol Biol (2011) 0.81

Crowning proteins: modulating the protein surface properties using crown ethers. Angew Chem Int Ed Engl (2014) 0.79

Utility of Synechocystis sp. PCC 6803 glutaredoxin A as a platform to study high-resolution mutagenesis of proteins. Front Plant Sci (2013) 0.79

Crystal structure of cindoxin, the P450cin redox partner. Biochemistry (2014) 0.79

Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase. Acta Crystallogr D Biol Crystallogr (2010) 0.79

Guidelines for the successful generation of protein-ligand complex crystals. Acta Crystallogr D Struct Biol (2017) 0.79

Improvement of the crystallizability and expression of an RNA crystallization chaperone. J Biochem (2011) 0.79

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model. J Med Chem (2015) 0.79

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure (2016) 0.78

The taming of small heat-shock proteins: crystallization of the alpha-crystallin domain from human Hsp27. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure (2013) 0.78

Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm. J Biol Chem (2012) 0.78

Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm. Nucleic Acids Res (2013) 0.78

Enhancing ubiquitin crystallization through surface-entropy reduction. Acta Crystallogr F Struct Biol Commun (2014) 0.78

Crysalis: an integrated server for computational analysis and design of protein crystallization. Sci Rep (2016) 0.77

Computational approaches to selecting and optimising targets for structural biology. Methods (2011) 0.77

Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein. J Virol (2011) 0.77

The Crystal Structures of the N-terminal Photosensory Core Module of Agrobacterium Phytochrome Agp1 as Parallel and Anti-parallel Dimers. J Biol Chem (2016) 0.77

Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein. J Biol Chem (2016) 0.77

Protein crystallization screens developed at the MRC Laboratory of Molecular Biology. Drug Discov Today (2016) 0.76

High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.76

Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture. Biochemistry (2016) 0.76

Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116†. Glycobiology (2017) 0.76

An unprecedented NADPH domain conformation in lysine monooxygenase NbtG provides insights into uncoupling of oxygen consumption from substrate hydroxylation. J Biol Chem (2015) 0.76

Structure and mechanism of the phage T4 recombination mediator protein UvsY. Proc Natl Acad Sci U S A (2016) 0.75

Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr F Struct Biol Commun (2015) 0.75

Design of an expression system to enhance MBP-mediated crystallization. Sci Rep (2017) 0.75

Protein surface shielding agents in protein crystallization. J Synchrotron Radiat (2010) 0.75

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. Biochemistry (2016) 0.75

Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep (2015) 0.75

Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis. Arch Biochem Biophys (2011) 0.75

Structural basis of nonribosomal peptide macrocyclization in fungi. Nat Chem Biol (2016) 0.75

Computational crystallization. Arch Biochem Biophys (2016) 0.75

A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun (2016) 0.75

Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana. PLoS One (2016) 0.75

Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc Natl Acad Sci U S A (2016) 0.75

Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus. PeerJ (2016) 0.75

Structure of the WD40-domain of human ATG16L1. Protein Sci (2017) 0.75

Structural and Chemical Biology of Terpenoid Cyclases. Chem Rev (2017) 0.75

Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners. Sci Rep (2017) 0.75

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep (2017) 0.75

Articles cited by this

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69

Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol (1999) 33.07

The atomic structure of protein-protein recognition sites. J Mol Biol (1999) 12.63

Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 7.29

Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol (2004) 4.07

Blocks+: a non-redundant database of protein alignment blocks derived from multiple compilations. Bioinformatics (1999) 3.70

Structural basis of interdomain communication in the Hsc70 chaperone. Mol Cell (2005) 3.34

Rational protein crystallization by mutational surface engineering. Structure (2004) 2.87

High-throughput protein crystallization. Curr Opin Struct Biol (2000) 2.50

Empirical scale of side-chain conformational entropy in protein folding. J Mol Biol (1993) 2.29

Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25

The use of recombinant methods and molecular engineering in protein crystallization. Methods (2004) 1.82

Extent and nature of contacts between protein molecules in crystal lattices and between subunits of protein oligomers. Proteins (1997) 1.79

B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins (2006) 1.47

Measures of residue density in protein structures. Proc Natl Acad Sci U S A (1999) 1.46

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution. Acta Crystallogr D Biol Crystallogr (2003) 1.29

The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins. J Mol Biol (2004) 1.17

Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. Structure (2001) 1.13

Structure and activity of the axon guidance protein MICAL. Proc Natl Acad Sci U S A (2005) 1.13

Atomic-resolution crystal structure of Borrelia burgdorferi outer surface protein A via surface engineering. Protein Sci (2006) 1.10

Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution. Acta Crystallogr D Biol Crystallogr (2004) 1.04

Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors. Acta Crystallogr D Biol Crystallogr (2005) 1.04

Structure and reaction mechanism of L-rhamnulose kinase from Escherichia coli. J Mol Biol (2006) 0.98

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. J Mol Biol (2006) 0.96

Surface-entropy reduction used in the crystallization of human choline acetyltransferase. Acta Crystallogr D Biol Crystallogr (2005) 0.92

Purification, crystallization and preliminary X-ray diffraction analysis of the phage T4 vertex protein gp24 and its mutant forms. Protein Expr Purif (2006) 0.88

Articles by these authors

The Database of Interacting Proteins: 2004 update. Nucleic Acids Res (2004) 23.67

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res (2002) 15.70

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99

Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56

Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature (2007) 10.02

The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24

Protein interactions: two methods for assessment of the reliability of high throughput observations. Mol Cell Proteomics (2002) 8.11

Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03

Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 7.29

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83

The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A (2003) 5.83

PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01

3D domain swapping: as domains continue to swap. Protein Sci (2002) 4.35

Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol (2004) 4.07

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78

Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci U S A (2010) 3.50

The origin of protein interactions and allostery in colocalization. Nature (2007) 3.34

Atomic view of a toxic amyloid small oligomer. Science (2012) 3.13

Continuation and satisfaction of reversible contraception. Obstet Gynecol (2011) 3.03

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature (2005) 2.99

Inference of protein function from protein structure. Structure (2005) 2.90

The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88

Computational methods of analysis of protein-protein interactions. Curr Opin Struct Biol (2003) 2.80

Describing biological protein interactions in terms of protein states and state transitions: the LiveDIP database. Mol Cell Proteomics (2002) 2.76

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague. Structure (2004) 2.53

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46

Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis. Infect Immun (2006) 2.27

Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol (2003) 2.25

The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nat Struct Biol (2003) 2.22

Recent atomic models of amyloid fibril structure. Curr Opin Struct Biol (2006) 2.05

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol (2003) 2.04

Ethical considerations of complementary and alternative medical therapies in conventional medical settings. Ann Intern Med (2002) 2.02

Inferring protein domain interactions from databases of interacting proteins. Genome Biol (2005) 1.97

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol Microbiol (2006) 1.97

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci (2010) 1.95

Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol (2009) 1.94

Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci (2008) 1.89

Deposition diseases and 3D domain swapping. Structure (2006) 1.88

Use of logic relationships to decipher protein network organization. Science (2004) 1.86

An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Proc Natl Acad Sci U S A (2004) 1.85

GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry (2002) 1.82

Genomic evidence that the intracellular proteins of archaeal microbes contain disulfide bonds. Proc Natl Acad Sci U S A (2002) 1.81

Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76

In silico simulation of biological network dynamics. Nat Biotechnol (2004) 1.74

GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. J Mol Biol (2002) 1.74

Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science (2003) 1.73

Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol (2008) 1.63

Cross-beta order and diversity in nanocrystals of an amyloid-forming peptide. J Mol Biol (2003) 1.59

Towards a pharmacophore for amyloid. PLoS Biol (2011) 1.58

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest (2008) 1.54

Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53

Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem (2008) 1.49

A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments. Proc Natl Acad Sci U S A (2006) 1.49

Structural models of amyloid-like fibrils. Adv Protein Chem (2006) 1.49

The MiSink Plugin: Cytoscape as a graphical interface to the Database of Interacting Proteins. Bioinformatics (2007) 1.49

A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell (2008) 1.48

B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins (2006) 1.47

Molecular basis for insulin fibril assembly. Proc Natl Acad Sci U S A (2009) 1.47

Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduction-oxidation process. Nat Struct Biol (2003) 1.46

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci (2009) 1.46

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle. Structure (2004) 1.45

Recurated protein interaction datasets. Nat Methods (2009) 1.43

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A (2012) 1.39

The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (2007) 1.36

The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase. Proc Natl Acad Sci U S A (2005) 1.33

Cooperative hydrogen bonding in amyloid formation. Protein Sci (2007) 1.33

Short protein segments can drive a non-fibrillizing protein into the amyloid state. Protein Eng Des Sel (2009) 1.31

Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res (2003) 1.31

Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol (2003) 1.30

The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord (2002) 1.28

Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics. J Am Chem Soc (2011) 1.27

Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry (2002) 1.27

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications. Structure (2004) 1.25

Structures of the two 3D domain-swapped RNase A trimers. Protein Sci (2002) 1.24

β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol (2010) 1.22

Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem (2003) 1.22

PDZ tandem of human syntenin: crystal structure and functional properties. Structure (2003) 1.21

The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution. Acta Crystallogr D Biol Crystallogr (2002) 1.21

The binding of the PDZ tandem of syntenin to target proteins. Biochemistry (2006) 1.19

The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins. J Mol Biol (2004) 1.17

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem (2012) 1.16

Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A (2006) 1.16

Two amyloid States of the prion protein display significantly different folding patterns. J Mol Biol (2010) 1.16

Using inferred residue contacts to distinguish between correct and incorrect protein models. Bioinformatics (2008) 1.15

A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen (2006) 1.14

Crystal structure of a RuBisCO-like protein from the green sulfur bacterium Chlorobium tepidum. Structure (2005) 1.14

Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry (2002) 1.13

Sociodemographic determinants of the utilization of specific types of complementary and alternative medicine: an analysis based on a nationally representative survey sample. J Altern Complement Med (2005) 1.13

Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm. Structure (2003) 1.13

Management of steal syndrome resulting from dialysis access. Semin Vasc Surg (2004) 1.12

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif. J Mol Biol (2006) 1.12

Utilizing logical relationships in genomic data to decipher cellular processes. FEBS J (2005) 1.11