Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMC 3992201)

Published in Biol Psychiatry on October 19, 2013

Authors

Joel Gelernter1, Henry R Kranzler2, Richard Sherva3, Ryan Koesterer4, Laura Almasy5, Hongyu Zhao6, Lindsay A Farrer7

Author Affiliations

1: Department of Psychiatry, Division of Human Genetics, Departments of Genetics and Neurobiology, Yale University School of Medicine, VA Connecticut Healthcare Center, West Haven. Electronic address: joel.gelernter@yale.edu.
2: Philadelphia VA Medical Center, Philadelphia, Pennsylvania.
3: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
4: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
5: Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas.
6: Departments Biostatistics and Genetics, Yale School of Public Health, Yale University, New Haven, CT.
7: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts; Departments of Neurology, Ophthalmology, Genetics and Genomics, Epidemiology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts.

Articles citing this

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Mol Psychiatry (2013) 1.97

Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. Biol Psychiatry (2014) 1.62

Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1. Biol Psychiatry (2015) 1.44

Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Mol Psychiatry (2013) 1.38

Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. Am J Hum Genet (2013) 1.10

Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence. Addiction (2015) 1.01

Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry (2016) 0.93

Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. Behav Genet (2015) 0.92

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Transl Psychiatry (2015) 0.90

Association Between Initial Opioid Prescribing Patterns and Subsequent Long-Term Use Among Opioid-Naïve Patients: A Statewide Retrospective Cohort Study. J Gen Intern Med (2016) 0.90

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet (2015) 0.86

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Transl Psychiatry (2016) 0.86

Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. Alcohol Clin Exp Res (2015) 0.85

Dissecting ancestry genomic background in substance dependence genome-wide association studies. Pharmacogenomics (2015) 0.84

Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. Public Health Genomics (2014) 0.84

The Genetics, Neurogenetics and Pharmacogenetics of Addiction. Curr Behav Neurosci Rep (2014) 0.83

Evidence of CNIH3 involvement in opioid dependence. Mol Psychiatry (2015) 0.83

Genetics of complex traits in psychiatry. Biol Psychiatry (2014) 0.83

FKBP5 variation is associated with the acute and chronic effects of nicotine. Pharmacogenomics J (2014) 0.81

Variations in opioid receptor genes in neonatal abstinence syndrome. Drug Alcohol Depend (2015) 0.80

DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep (2016) 0.79

XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology (2014) 0.79

KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. Addict Biol (2015) 0.78

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. BMC Syst Biol (2015) 0.78

The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology (2016) 0.78

Genetic association of impulsivity in young adults: a multivariate study. Transl Psychiatry (2014) 0.77

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes. Am J Med Genet B Neuropsychiatr Genet (2014) 0.77

Genome-wide association study of copy number variations (CNVs) with opioid dependence. Neuropsychopharmacology (2014) 0.77

The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Transl Psychiatry (2014) 0.77

Convergent functional genomics in addiction research - a translational approach to study candidate genes and gene networks. In Silico Pharmacol (2013) 0.76

Association of genes involved in calcium and potassium pathways with opioid dependence. Biol Psychiatry (2014) 0.76

A Review of Genome-Wide Association Studies of Stimulant and Opioid Use Disorders. Mol Neuropsychiatry (2016) 0.75

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology. Transl Psychiatry (2016) 0.75

A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Mol Psychiatry (2016) 0.75

Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum Genet (2016) 0.75

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome. PLoS One (2017) 0.75

Refining multivariate disease phenotypes for high chip heritability. BMC Med Genomics (2015) 0.75

An Effective Method to Identify Heritable Components from Multivariate Phenotypes. PLoS One (2015) 0.75

Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry (2017) 0.75

Genome-Wide Association of Heroin Dependence in Han Chinese. PLoS One (2016) 0.75

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample. J Stud Alcohol Drugs (2016) 0.75

Large-scale interaction effects reveal missing heritability in schizophrenia, bipolar disorder and posttraumatic stress disorder. Transl Psychiatry (2017) 0.75

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

A map of human genome variation from population-scale sequencing. Nature (2010) 121.13

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

Longitudinal data analysis for discrete and continuous outcomes. Biometrics (1986) 60.93

Population structure and eigenanalysis. PLoS Genet (2006) 37.21

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09

METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature (2008) 18.21

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A (1991) 16.94

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet (2013) 13.17

Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) (2005) 9.85

Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90

Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80

The genetics of addictions: uncovering the genes. Nat Rev Genet (2005) 5.05

Association within a family of a balanced autosomal translocation with major mental illness. Lancet (1990) 3.94

Local potassium signaling couples neuronal activity to vasodilation in the brain. Nat Neurosci (2006) 3.27

Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug Alcohol Depend (2005) 3.09

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci U S A (2008) 2.37

Drug wanting: behavioral sensitization and relapse to drug-seeking behavior. Pharmacol Rev (2011) 2.30

Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia. Am J Med Genet B Neuropsychiatr Genet (2005) 2.24

Effects of differential genotyping error rate on the type I error probability of case-control studies. Hum Hered (2006) 2.21

Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet (2006) 2.15

The collaborative study on the genetics of alcoholism: an update. Alcohol Res Health (2002) 1.97

CACNA1C (rs1006737) is associated with schizophrenia. Mol Psychiatry (2010) 1.93

Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings. Drug Alcohol Depend (2008) 1.79

Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Mol Psychiatry (2013) 1.38

The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc (2009) 1.28

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones. Br J Pharmacol (1983) 1.16

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits. Mol Psychiatry (2013) 1.05

Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. J Neurosci (2011) 0.96

Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem (2011) 0.92

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Hum Mutat (2005) 0.90

Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addict Biol (2013) 0.90

Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. Subst Use Misuse (2010) 0.88

Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. Biol Psychiatry (2012) 0.88

Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Hum Genet (2008) 0.84