Published in J Cereb Blood Flow Metab on October 23, 2013
Integrative regulation of human brain blood flow. J Physiol (2014) 1.85
False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward. Neurophotonics (2016) 1.00
The effects of transit time heterogeneity on brain oxygenation during rest and functional activation. J Cereb Blood Flow Metab (2014) 0.86
The effects of capillary transit time heterogeneity (CTH) on brain oxygenation. J Cereb Blood Flow Metab (2015) 0.85
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation. Neuron (2016) 0.84
The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements. Philos Trans R Soc Lond B Biol Sci (2016) 0.80
Mechanical and Biological Interactions of Implants with the Brain and Their Impact on Implant Design. Front Neurosci (2016) 0.77
Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci (2016) 0.76
Abnormal oxygen homeostasis in the nucleus tractus solitarii of the spontaneously hypertensive rat. Exp Physiol (2017) 0.75
The Effects of Capillary Transit Time Heterogeneity (CTH) on the Cerebral Uptake of Glucose and Glucose Analogs: Application to FDG and Comparison to Oxygen Uptake. Front Comput Neurosci (2016) 0.75
Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model. Front Neural Circuits (2016) 0.75
Volumetric Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI. Sci Rep (2017) 0.75
Modelling the effects of cerebral microvasculature morphology on oxygen transport. Med Eng Phys (2015) 0.75
Energetic Constraints Produce Self-sustained Oscillatory Dynamics in Neuronal Networks. Front Neurosci (2017) 0.75
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A (1992) 16.64
Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A (1992) 14.96
An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab (2001) 11.01
Nonoxidative glucose consumption during focal physiologic neural activity. Science (1988) 9.59
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A (1986) 9.31
Oxidative phosphorylations; rôle of inorganic phosphate and acceptor systems in control of metabolic rates. J Biol Chem (1952) 7.81
Respiratory enzymes in oxidative phosphorylation. III. The steady state. J Biol Chem (1955) 7.56
The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J Physiol (1919) 6.74
Glial and neuronal control of brain blood flow. Nature (2010) 6.61
Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A (1998) 6.02
Glial regulation of the cerebral microvasculature. Nat Neurosci (2007) 5.91
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci (2011) 5.64
Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science (1996) 5.40
A vertebrate globin expressed in the brain. Nature (2000) 5.34
Arterial blood gases and oxygen content in climbers on Mount Everest. N Engl J Med (2009) 5.28
Bidirectional control of CNS capillary diameter by pericytes. Nature (2006) 5.27
Cytosolic phosphorylation potential. J Biol Chem (1979) 4.90
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol (1985) (2006) 4.43
Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature (2008) 4.32
Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science (1997) 4.29
Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A (1999) 3.44
A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab (1997) 3.20
Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage (2007) 3.07
Single-neuron activity and tissue oxygenation in the cerebral cortex. Science (2003) 2.96
Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol (2001) 2.81
Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci (2007) 2.76
Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. Circ Res (1994) 2.65
Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex. Neuroimage (2001) 2.43
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods (2010) 2.37
Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proc Natl Acad Sci U S A (1997) 2.28
Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci (1994) 2.24
MRI measurement of the temporal evolution of relative CMRO(2) during rat forepaw stimulation. Magn Reson Med (1999) 2.15
No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation. Neuroimage (2001) 2.07
ATP and brain function. J Cereb Blood Flow Metab (1989) 2.05
Nitric oxide and mitochondrial respiration. Biochim Biophys Acta (1999) 2.02
Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats. Pflugers Arch (1999) 1.99
Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol (1990) 1.95
Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science (1999) 1.93
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci U S A (2010) 1.91
Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function. Proc Natl Acad Sci U S A (1985) 1.86
How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J Biol Chem (2002) 1.85
Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab (2012) 1.81
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism. Front Neuroenergetics (2010) 1.77
The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism. J Cereb Blood Flow Metab (2011) 1.76
Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol (2001) 1.72
Activity-induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow. J Physiol (2005) 1.70
Intracellular diffusion gradients of O2 and ATP. Am J Physiol (1986) 1.66
Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol (1998) 1.65
Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions. J Cereb Blood Flow Metab (2010) 1.64
Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study. Neuroimage (2007) 1.63
Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics (2010) 1.59
Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain. Proc Natl Acad Sci U S A (2004) 1.57
Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation. Proc Natl Acad Sci U S A (2000) 1.54
In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia. J Cereb Blood Flow Metab (2001) 1.52
Early temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation. J Cereb Blood Flow Metab (2000) 1.50
Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab (1999) 1.50
A model for the regulation of cerebral oxygen delivery. J Appl Physiol (1985) (1998) 1.49
Revisiting the role of neurons in neurovascular coupling. Front Neuroenergetics (2010) 1.48
Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (2003) 1.47
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J Neurosci (2012) 1.47
Human cerebral circulation: positron emission tomography studies. Ann Nucl Med (2005) 1.46
Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance. Proc Natl Acad Sci U S A (1986) 1.46
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex. Proc Natl Acad Sci U S A (2010) 1.44
"Overshoot" of O₂ is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci (2011) 1.44
Brain tissue oxygen concentration measurements. Antioxid Redox Signal (2007) 1.42
Oxygen pressure gradients in isolated cardiac myocytes. J Biol Chem (1985) 1.38
Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation. Neuroimage (2002) 1.37
Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling. J Neurosci (2010) 1.35
Model of blood-brain transfer of oxygen explains nonlinear flow-metabolism coupling during stimulation of visual cortex. J Cereb Blood Flow Metab (2000) 1.35
Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex. J Cereb Blood Flow Metab (2009) 1.34
Oxidative and nonoxidative metabolism of excited neurons and astrocytes. J Cereb Blood Flow Metab (2002) 1.33
High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A (2000) 1.31
Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. Am J Physiol (1999) 1.30
Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab (2011) 1.29
Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex. Neuroimage (2000) 1.28
Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF. Magn Reson Med (2008) 1.27
The neurovascular unit in brain function and disease. Acta Physiol (Oxf) (2011) 1.27
Cell respiration is controlled by ATP, an allosteric inhibitor of cytochrome-c oxidase. Eur J Biochem (1997) 1.25
Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. J Cereb Blood Flow Metab (2009) 1.24
Interdependency of local capillary density, blood flow, and metabolism in rat brains. Am J Physiol (1986) 1.23
CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias. Neuroimage (2007) 1.22
Brain energy metabolism and blood flow differences in healthy aging. J Cereb Blood Flow Metab (2012) 1.20
Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain. Ann Neurol (2005) 1.19
Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab (2005) 1.16
Pharmacological uncoupling of activation induced increases in CBF and CMRO2. J Cereb Blood Flow Metab (2009) 1.16
Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. J Cereb Blood Flow Metab (1997) 1.16
Autoradiographic determination of regional brain glucose content. J Cereb Blood Flow Metab (1983) 1.15
Quantitative evolutionary design. J Physiol (2002) 1.13
The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model. J Cereb Blood Flow Metab (2013) 1.12
Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses. Neuroimage (2008) 1.11
Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigm. Neuroimage (2006) 1.11
Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit. Am J Physiol Endocrinol Metab (2005) 1.10
Role of phosphocreatine in energy transport in skeletal muscle of bullfrog studied by 31P-NMR. Biochim Biophys Acta (1990) 1.10
Dynamic changes in cerebral blood flow, O2 tension, and calculated cerebral metabolic rate of O2 during functional activation using oxygen phosphorescence quenching. J Cereb Blood Flow Metab (2001) 1.10
Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol (2003) 1.08
The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases. Brain (1988) 1.08
Regulation of ATP production by mitochondrial Ca(2+). Cell Calcium (2012) 1.07
Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses. Neuroimage (2012) 1.07
Dependence of oxygen delivery on blood flow in rat brain: a 7 tesla nuclear magnetic resonance study. J Cereb Blood Flow Metab (2000) 1.07
Pharmacological uncoupling of activation induced increases in CBF and CMRO2. J Cereb Blood Flow Metab (2009) 1.16